Michael R. Irwin
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View article: Inflammation-induced depressed mood and reward responsivity as a function of age in female adults: a randomized controlled trial of endotoxin
Inflammation-induced depressed mood and reward responsivity as a function of age in female adults: a randomized controlled trial of endotoxin Open
Younger female adults are more vulnerable to depression than older females, potentially due to a greater affective response to inflammation. This randomized, double-blind, placebo-controlled study evaluated depressed mood and reward respon…
View article: Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial
Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial Open
Objective To assess whether tai chi is non-inferior to cognitive behavioural therapy for insomnia (CBT-I), the first line treatment, for managing chronic insomnia in middle aged and older adults. Design Randomised, assessor masked, non-inf…
View article: Insomnia and elevated risk of major depressive disorder in older adult, long-term breast cancer survivors vs a matched cohort
Insomnia and elevated risk of major depressive disorder in older adult, long-term breast cancer survivors vs a matched cohort Open
Study Objectives Depression frequently occurs after diagnosis of breast cancer diagnosis. This study examines the incidence of depression and whether insomnia exaggerates depression risk in long-term breast cancer survivors (BCSs). Methods…
View article: Inflammation and dimensions of fatigue in women with early stage breast cancer: A longitudinal examination
Inflammation and dimensions of fatigue in women with early stage breast cancer: A longitudinal examination Open
Background Fatigue is a common and long‐lasting side effect of cancer. Although fatigue is a multidimensional symptom, biologic mechanisms of fatigue dimensions have not been identified. Methods Women recently diagnosed with early stage br…
View article: Inflammatory Exposure and Depression in Older Adults With Insomnia
Inflammatory Exposure and Depression in Older Adults With Insomnia Open
Importance Insomnia and inflammation are prevalent in older adults, and both are risk factors for late-life depression. Older adults with insomnia who are exposed to inflammatory challenge may be more vulnerable to depression. Objective To…
View article: Project HERO: a randomized trial of Tai Chi qigong versus intensity-matched exercise and usual care for fatigue in older male cancer survivors
Project HERO: a randomized trial of Tai Chi qigong versus intensity-matched exercise and usual care for fatigue in older male cancer survivors Open
Background Fatigue is often one of the most commonly reported symptoms in older male cancer survivors, but it is also one of the least understood cancer-related symptoms. Fatigue is associated with psychological distress, disruptions in sl…
View article: Randomised, controlled clinical trial evaluating the effects of preoperative insomnia treatment on postoperative pain control and recovery: a protocol for the Promoting Sleep to Alleviate Pain-Arthroplasty (PROSAP-A) trial
Randomised, controlled clinical trial evaluating the effects of preoperative insomnia treatment on postoperative pain control and recovery: a protocol for the Promoting Sleep to Alleviate Pain-Arthroplasty (PROSAP-A) trial Open
Introduction Sleep is a biological necessity with vital effects on all tissues and organs of the body. Preoperative sleep disturbance is associated with increased postoperative pain intensity and opioid consumption. Given that insomnia is …
View article: Psychological intervention in individuals with subthreshold depression: individual participant data meta-analysis of treatment effects and moderators
Psychological intervention in individuals with subthreshold depression: individual participant data meta-analysis of treatment effects and moderators Open
Background It remains unclear which individuals with subthreshold depression benefit most from psychological intervention, and what long-term effects this has on symptom deterioration, response and remission. Aims To synthesise psychologic…
View article: Insomnia and Inflammation Conspire to Heighten Depression Risk: Implications for Treatment and Prevention of Mood Disorders
Insomnia and Inflammation Conspire to Heighten Depression Risk: Implications for Treatment and Prevention of Mood Disorders Open
Insomnia is ubiquitous, is comorbid with all major mental disorders, increases the risk of depression, and contributes to inflammatory morbidity and all-cause mortality. This review examines the relationships between insomnia and inflammat…
View article: A Neuroimmune Modulator for Alcohol Use Disorder
A Neuroimmune Modulator for Alcohol Use Disorder Open
Importance The neuroimmune system represents a promising target for novel medications for alcohol use disorder (AUD). Ibudilast is a neuroimmune modulator which selectively inhibits phosphodiesterases (PDE) 3, PDE4, PDE10, and PDE11, and m…
View article: Identification of Symptom Profiles in Prostate Cancer Survivors
Identification of Symptom Profiles in Prostate Cancer Survivors Open
Prostate cancer survivors experience varying degrees of symptom severity. Understanding the symptom profiles and associated factors can inform nurses about patients in need of symptom management and targeted interventions.
View article: Insomnia remission and improvement of bodily pain in older adults: a randomized clinical trial
Insomnia remission and improvement of bodily pain in older adults: a randomized clinical trial Open
Introduction: Older adults with insomnia frequently report bothersome pain. Whether insomnia treatment reduces bodily pain in older adults without chronic pain conditions is not known. Objectives: This randomized controlled trial aimed to …
View article: Kynurenine Metabolism is Associated with Antidepressant Response to Selective Serotonin Reuptake Inhibitors
Kynurenine Metabolism is Associated with Antidepressant Response to Selective Serotonin Reuptake Inhibitors Open
Alterations in the kynurenine pathway, and in particular the balance of neuroprotective and neurotoxic metabolites, have been implicated in the pathophysiology of Major Depressive Disorder (MDD) and antidepressant treatment response. In th…
View article: Elevations in interleukin‐8 levels in individuals with alcohol use disorder and clinical insomnia symptoms
Elevations in interleukin‐8 levels in individuals with alcohol use disorder and clinical insomnia symptoms Open
Background Insomnia commonly co‐occurs with alcohol use disorder (AUD) and predicts poorer outcomes for those with AUD. Insomnia and AUD are individually associated with increases in systemic inflammation. Insomnia and inflammation both se…
View article: Sex differences in the transcriptional response to acute inflammatory challenge: A randomized controlled trial of endotoxin
Sex differences in the transcriptional response to acute inflammatory challenge: A randomized controlled trial of endotoxin Open
This work suggests CREB signaling as a critical upstream biological pathway that should be further interrogated as a mechanism of female vulnerability to immune-related disorders. Future work should clarify whether increased CREB signaling…
View article: Family meals are associated with lower substance use in female adolescents
Family meals are associated with lower substance use in female adolescents Open
Adolescents, especially female youth, who have more family meals tend to be at lower risk for substance use. The present study tested whether family meals relate to substance use count and frequency during high school, whether associations…
View article: Differential inflammatory profiles in carriers of reciprocal 22q11.2 copy number variants
Differential inflammatory profiles in carriers of reciprocal 22q11.2 copy number variants Open
Our results suggest that CNVs at the 22q11.2 locus may have differential effects on inflammatory processes related to IL-8, a key mediator of inflammation produced by macrophages and microglia. Further, these IL-8-mediated inflammatory pro…
View article: Associations between emotional reactivity to stress and adolescent substance use: Differences by sex and valence
Associations between emotional reactivity to stress and adolescent substance use: Differences by sex and valence Open
Although stress is often related to substance use, it remains unclear whether substance use is related to individual differences in how adolescents respond to stress. Therefore the present study examined associations between substance use …
View article: Exploring the Impact of a Sleep App on Sleep Quality in a General Population Sample: Pilot Randomized Controlled Trial
Exploring the Impact of a Sleep App on Sleep Quality in a General Population Sample: Pilot Randomized Controlled Trial Open
Background A third of adults in Western countries have impaired sleep quality. A possible solution involves distributing sleep aids through smartphone apps, but most empirical studies are limited to small pilot trials in distinct populatio…
View article: Sleep Disturbance as a Mediator of Lung Cancer Stigma on Psychological Distress and Physical Symptom Burden
Sleep Disturbance as a Mediator of Lung Cancer Stigma on Psychological Distress and Physical Symptom Burden Open
Objective This study tested sleep disturbance as a mediator through which stigma and discrimination predict psychological distress and physical symptom burden in adults with lung cancer. Methods Lung cancer patients on active oncological t…
View article: IL-6 predicts non-suicidal self-injury over 3 months in high-risk adolescents
IL-6 predicts non-suicidal self-injury over 3 months in high-risk adolescents Open
Background Suicide is the second leading cause of death in 12- to 17-year-old adolescents in the USA. Research on biological mechanisms contributing to self-harm risk that could be targeted in treatment could help to prevent suicide and se…
View article: Sleep–wake behavioral characteristics associated with depression symptoms: findings from the Multi-Ethnic Study of Atherosclerosis
Sleep–wake behavioral characteristics associated with depression symptoms: findings from the Multi-Ethnic Study of Atherosclerosis Open
Study Objectives To help prioritize target/groups for experimental intervention studies, we characterized cross-sectional associations between 24-hour sleep–wake measures and depression symptoms, and evaluated if similar sleep–wake–depress…
View article: The feasibility of a sleep education program for informal dementia care dyads: A pilot randomized controlled trial
The feasibility of a sleep education program for informal dementia care dyads: A pilot randomized controlled trial Open
Background Untreated sleep problems in both persons living with dementia (PLWD) and their family care partners (CP) impact their health and quality of life. This pilot study tested a sleep intervention program for both dyad members. Method…