Cheong Ngai
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View article: Osteogenic Circulating Endothelial Progenitor Cells are Associated with Vascular Aging of the Large Arteries in Rheumatoid Arthritis
Osteogenic Circulating Endothelial Progenitor Cells are Associated with Vascular Aging of the Large Arteries in Rheumatoid Arthritis Open
Yap-Hang Chan,1 Michael Cheong Ngai,2 Yan Chen,1,3 Mei-Zhen Wu,1 Yu-Juan Yu,1 Zhe Zhen,1 Kevin Lai,1 Ho-Yin Chung,4 Chak-Sing Lau,4 Hung-Fat Tse,1,3 Kai-Hang Yiu1,3 1Cardiology Division, Department of Medicine, Queen Mary Hospital, Univers…
View article: The impact of bortezomib-based induction in newly diagnosed multiple myeloma with chromosome 1q21 gain
The impact of bortezomib-based induction in newly diagnosed multiple myeloma with chromosome 1q21 gain Open
Introduction: Bortezomib has been reported to favourably impact the outcomes of t(4;14) and del(17p) in multiple myeloma (MM), but its impact on gain 1q (+1q) is unknown. Methods: To address this, 250 patients treated with bortezomib-based…
View article: 3-weekly daratumumab-lenalidomide/pomalidomide-dexamethasone is highly effective in relapsed and refractory multiple myeloma
3-weekly daratumumab-lenalidomide/pomalidomide-dexamethasone is highly effective in relapsed and refractory multiple myeloma Open
This 3-weekly dara-IMiD-dex regimen preserves a high efficacy with rapid, deep responses including MRD-ve and PET-ve CR, hence a cost-effective regimen.
View article: Case series: MRD negativity assessment using <sup>11</sup>C-Acetate PET with 3-weekly daratumumab-based quadruplet induction in newly diagnosed multiple myeloma
Case series: MRD negativity assessment using <sup>11</sup>C-Acetate PET with 3-weekly daratumumab-based quadruplet induction in newly diagnosed multiple myeloma Open
Complete response (CR) is an important favorable factor for survival in multiple myeloma (MM). However, CR patients continue to relapse, especially in the presence of minimal residual disease (MRD). Bone marrow (BM) MRD is predictive of pr…
View article: Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification
Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification Open
Background Rheumatic diseases are related to both abnormal bone turnover and atherogenesis, but a mechanistic link was missing. Methods and Results We investigated the effect of cumulative rheumatic inflammation ( CRI ) on risk of coronary…
View article: Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients
Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients Open
Background Osteogenic circulating endothelial progenitor cells (EPC) play a pathogenic role in cardiovascular system degeneration through promulgating vasculature calcification, but its role in conduction disorders as part of the cardiovas…