Michael Nugent
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View article: Lightfastness of polypropylene pigmented with natural indigo of Isatis Tinctoria
Lightfastness of polypropylene pigmented with natural indigo of Isatis Tinctoria Open
Purpose The purpose of this study is to purify natural indigo powder with hydrochloric acid (HCl) and study how purification affects the light fastness of the pigment, both in a dimethyl sulfoxide (DMSO) solution and inside a polypropylene…
View article: Valorisation of invasive plant ( <i>Rhododendron ponticum</i> ) biomass into activated biochar as a sustainable adsorbent for emerging pharmaceutical contaminant removal from water
Valorisation of invasive plant ( <i>Rhododendron ponticum</i> ) biomass into activated biochar as a sustainable adsorbent for emerging pharmaceutical contaminant removal from water Open
The common issue of water contamination by pharmaceuticals are increasingly recognised as emerging contaminants in water as they pose significant environmental and health risks, necessitating innovative and sustainable approaches to water …
View article: Effect of organic biocolourants on lightfastness and mechanical properties of polylactic acid
Effect of organic biocolourants on lightfastness and mechanical properties of polylactic acid Open
Most modern colourants are acquired from petroleum‐based sources or mining, which often causes environmental degradation. Consequently, alternative colouring solutions are sought, such as using biocolourants, which are organic colourants f…
View article: In-line NIR coupled with machine learning to predict mechanical properties and dissolution profile of PLA-Aspirin
In-line NIR coupled with machine learning to predict mechanical properties and dissolution profile of PLA-Aspirin Open
View article: Co-axial electrosprayed RAD001-loaded polycaprolactone/polyvinyl alcohol core–shell particles for treating pediatric brain tumours
Co-axial electrosprayed RAD001-loaded polycaprolactone/polyvinyl alcohol core–shell particles for treating pediatric brain tumours Open
Core-shell particles composed of polycaprolactone/polyvinyl alcohol (PCL/PVA) with pH sensitive properties were successfully fabricated by co-axial electrospraying in which PVA and PCL formed the shell and core layers respectively. The cor…
View article: Ph Responsive Drug Carrier Polycaprolactone/Polyvinyl Alcohol Core-Shell Particles Loaded with Rad001 as a Potential Application in the Treatment of Pediatric Brain Tumours
Ph Responsive Drug Carrier Polycaprolactone/Polyvinyl Alcohol Core-Shell Particles Loaded with Rad001 as a Potential Application in the Treatment of Pediatric Brain Tumours Open
View article: Design, development and in vitro quantification of novel electrosprayed everolimus-loaded Soluplus®/Polyvinyl alcohol nanoparticles via stability-indicating HPLC method in cancer therapy
Design, development and in vitro quantification of novel electrosprayed everolimus-loaded Soluplus®/Polyvinyl alcohol nanoparticles via stability-indicating HPLC method in cancer therapy Open
Everolimus (RAD001) a mammalian target of rapamycin has been hampered by poor solubility, affecting its dissolution rate, a relationship that extends to low bioavailability. Nanoparticles (NP) based on Soluplus (SOL®) and Polyvinyl alcohol…
View article: Nanofibrillated cellulose originated from Rhododendron ponticum to produce scaffolds using 3D printing for biomedical applications
Nanofibrillated cellulose originated from Rhododendron ponticum to produce scaffolds using 3D printing for biomedical applications Open
Rhododendron ponticum is an invasive species that spreads rapidly and is described as one of the biggest threats to peatlands in Ireland. This study offers an innovative approach to utilizing Rhododendron waste. Initially, sawdust was subm…
View article: Electrospun Drug-Loaded and Gene-Loaded Nanofibres: The Holy Grail of Glioblastoma Therapy?
Electrospun Drug-Loaded and Gene-Loaded Nanofibres: The Holy Grail of Glioblastoma Therapy? Open
To date, GBM remains highly resistant to therapies that have shown promising effects in other cancers. Therefore, the goal is to take down the shield that these tumours are using to protect themselves and proliferate unchecked, regardless …
View article: Novel polyvinyl-alcohol microsphere for everolimus delivery for subependymal giant cell astrocytoma
Novel polyvinyl-alcohol microsphere for everolimus delivery for subependymal giant cell astrocytoma Open
Everolimus (EVR) has demonstrated efficacy in treating subependymal giant cell astrocytoma (SEGA) and other tuberous sclerosis (TSC) manifestations. Oral use of EVR is associated with low bioavailability and systemic toxicities culminating…
View article: Characterization of Gels and Films Produced from Pinhão Seed Coat Nanocellulose as a Potential Use for Wound Healing Dressings and Screening of Its Compounds towards Antitumour Effects
Characterization of Gels and Films Produced from Pinhão Seed Coat Nanocellulose as a Potential Use for Wound Healing Dressings and Screening of Its Compounds towards Antitumour Effects Open
The reuse of agro-industrial waste assumes great importance today. Pinhão is the seed of Araucaria angustifolia, which is native to the mountains of southern Brazil, Paraguay, and Argentina. The coat is a by-product of this seed and is ric…
View article: Plasma electrolytic oxidation up to four-steps performed on niobium and Nb-Ti alloys
Plasma electrolytic oxidation up to four-steps performed on niobium and Nb-Ti alloys Open
View article: Self-Photopolymerizable Hydrogel–Ceramic Composites with Scavenger Properties
Self-Photopolymerizable Hydrogel–Ceramic Composites with Scavenger Properties Open
The photocatalytic behaviours of semiconductive ceramic nanoparticles such as TiO2, ZnO, Fe2O3, and Fe3O4, have been extensively studied in photocatalysis and photopolymerization, due to their ability to produce radical species under ultra…
View article: Machine Learning for Process Monitoring and Control of Hot-Melt Extrusion: Current State of the Art and Future Directions
Machine Learning for Process Monitoring and Control of Hot-Melt Extrusion: Current State of the Art and Future Directions Open
In the last few decades, hot-melt extrusion (HME) has emerged as a rapidly growing technology in the pharmaceutical industry, due to its various advantages over other fabrication routes for drug delivery systems. After the introduction of …
View article: Effect of thermal annealing on a bilayer polyvinyl alcohol/polyacrylic acid electrospun hydrogel nanofibres loaded with doxorubicin and clarithromycin for a synergism effect against osteosarcoma cells
Effect of thermal annealing on a bilayer polyvinyl alcohol/polyacrylic acid electrospun hydrogel nanofibres loaded with doxorubicin and clarithromycin for a synergism effect against osteosarcoma cells Open
Polyvinyl alcohol/polyacrylic acid (PVA/PAA) bilayer hydrogel nanofibres were successfully fabricated by electrospinning and physically crosslinked via heat treatment. The effects of the thermal annealing process on the structure, morpholo…
View article: Development, Characterization and Cell Viability Inhibition of PVA Spheres Loaded with Doxorubicin and 4′-Amino-1-Naphthyl-Chalcone (D14) for Osteosarcoma
Development, Characterization and Cell Viability Inhibition of PVA Spheres Loaded with Doxorubicin and 4′-Amino-1-Naphthyl-Chalcone (D14) for Osteosarcoma Open
Chalcones (1,3-diaryl-2-propen-1-ones) are naturally occurring polyphenols with known anticancer activity against a variety of tumor cell lines, including osteosarcoma (OS). In this paper, we present the preparation and characterization of…
View article: Microfibrillated cellulose films containing chitosan and tannic acid for wound healing applications
Microfibrillated cellulose films containing chitosan and tannic acid for wound healing applications Open
View article: Antimicrobial PAA/PAH Electrospun Fiber Containing Green Synthesized Zinc Oxide Nanoparticles for Wound Healing
Antimicrobial PAA/PAH Electrospun Fiber Containing Green Synthesized Zinc Oxide Nanoparticles for Wound Healing Open
Wound infections are the main complication when treating skin wounds. This work reports a novel antimicrobial material using green synthesized zinc oxide nanoparticles (ZnONPs) incorporated in polymeric fibers for wound healing purposes. Z…
View article: Ti-25Nb-25Ta alloy treated by plasma electrolytic oxidation in phosphoric acid for implant applications
Ti-25Nb-25Ta alloy treated by plasma electrolytic oxidation in phosphoric acid for implant applications Open
Among titanium alloys with non-toxic elements, the Ti-25Nb-25Ta alloy has good elastic behavior for applications in osseous implants, biocompatibility, and excellent corrosion resistance. The present study aimed to better the biocompatibil…
View article: Titanium-Niobium (Ti-xNb) Alloys with High Nb Amounts for Applications in Biomaterials
Titanium-Niobium (Ti-xNb) Alloys with High Nb Amounts for Applications in Biomaterials Open
The present study produced binary titanium-niobium alloys Ti-xNb with high niobium percentage (x = 50, 80 e 90 wt.%) aiming to apply it as a base material in osseous implant devices. The produced TiNb alloys presented a cubic crystalline p…
View article: Ti-25Nb-25Ta alloy treated by plasma electrolytic oxidation in phosphoric acid for implant applications
Ti-25Nb-25Ta alloy treated by plasma electrolytic oxidation in phosphoric acid for implant applications Open
Among titanium alloys with non-toxic elements, the Ti-25Nb-25Ta alloy has good elastic behavior for applications in osseous implants, biocompatibility, and excellent corrosion resistance. The present study aimed to better the biocompatibil…
View article: Yerba Mate Extract in Microfibrillated Cellulose and Corn Starch Films as a Potential Wound Healing Bandage
Yerba Mate Extract in Microfibrillated Cellulose and Corn Starch Films as a Potential Wound Healing Bandage Open
Microfibrillated cellulose films have been gathering considerable attention due to their high mechanical properties and cheap cost. Additionally, it is possible to include compounds within the fibrillated structure in order to confer desir…
View article: Titanium-Niobium (Ti-xNb) Alloys with High Nb Amounts for Applications in Biomaterials
Titanium-Niobium (Ti-xNb) Alloys with High Nb Amounts for Applications in Biomaterials Open
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View article: Oxide coating containing apatite formed on Ti-25Nb-25Ta alloy treated by Two-Step Plasma Electrolytic Oxidation
Oxide coating containing apatite formed on Ti-25Nb-25Ta alloy treated by Two-Step Plasma Electrolytic Oxidation Open
View article: Water and Sewer Extension Policies as a Technique for Guiding Development
Water and Sewer Extension Policies as a Technique for Guiding Development Open
It would be difficult, no doubt, to find any relatively informed observer of urban affairs who would not decry the many undesirable aspects of urban sprawl. Planner and decision-maker alike are too well aware of the substantial costs assoc…
View article: Pulsed-UV disinfection of Polyvinyl alcohol-based films inoculated with Bacillus cereus endospores
Pulsed-UV disinfection of Polyvinyl alcohol-based films inoculated with Bacillus cereus endospores Open
View article: Extraction Method Plays Critical Role in Antibacterial Activity of Propolis-Loaded Hydrogels
Extraction Method Plays Critical Role in Antibacterial Activity of Propolis-Loaded Hydrogels Open