Michael O. Duff
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View article: Precise targeting of HIV broadly neutralizing antibody precursors in humans
Precise targeting of HIV broadly neutralizing antibody precursors in humans Open
A protective HIV vaccine will need to induce broadly neutralizing antibodies (bnAbs) in humans, but priming rare bnAb precursor B cells has been challenging. In a double-blinded, placebo-controlled phase 1 human clinical trial, the recombi…
View article: Author Correction: Perspectives on ENCODE
Author Correction: Perspectives on ENCODE Open
In this Article, the authors Rizi Ai (Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA) and Shantao Li (Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, US…
View article: Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes
Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes Open
View article: Author Correction: A large-scale binding and functional map of human RNA-binding proteins
Author Correction: A large-scale binding and functional map of human RNA-binding proteins Open
View article: Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia
Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia Open
Hereditary spastic paraplegias (HSPs) are caused by a length-dependent axonopathy of long corticospinal neurons, but how axons of these cortical projection neurons (PNs) degenerate remains elusive. We generated isogenic human pluripotent s…
View article: Expanded encyclopaedias of DNA elements in the human and mouse genomes
Expanded encyclopaedias of DNA elements in the human and mouse genomes Open
View article: Perspectives on ENCODE
Perspectives on ENCODE Open
The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulati…
View article: A large-scale binding and functional map of human RNA-binding proteins
A large-scale binding and functional map of human RNA-binding proteins Open
View article: Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers Open
Although increased RDW is predictive of cardiovascular outcomes, this was not explained by known CVD or related lipid genetic risks, and a RDW genetic score was not predictive of incident disease. The predictive value of RDW for a range of…
View article: Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice
Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice Open
Epidemiologic data has linked obesity to a higher risk of pancreatic cancer, but the underlying mechanisms are poorly understood. To allow for detailed mechanistic studies in a relevant model mimicking diet-induced obesity and pancreatic c…
View article: A Large-Scale Binding and Functional Map of Human RNA Binding Proteins
A Large-Scale Binding and Functional Map of Human RNA Binding Proteins Open
Genomes encompass all the information necessary to specify the development and function of an organism. In addition to genes, genomes also contain a myriad of functional elements that control various steps in gene expression. A major class…
View article: Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers
Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers Open
Variability in red blood cell volumes (distribution width, RDW) increases with age and is strongly predictive of mortality, incident coronary heart disease and cancer. We investigated inherited genetic variation associated with RDW in 116,…
View article: Global Analysis of Mouse Polyomavirus Infection Reveals Dynamic Regulation of Viral and Host Gene Expression and Promiscuous Viral RNA Editing
Global Analysis of Mouse Polyomavirus Infection Reveals Dynamic Regulation of Viral and Host Gene Expression and Promiscuous Viral RNA Editing Open
Mouse polyomavirus (MPyV) lytically infects mouse cells, transforms rat cells in culture, and is highly oncogenic in rodents. We have used deep sequencing to follow MPyV infection of mouse NIH3T6 cells at various times after infection and …
View article: Extensive cross-regulation of post-transcriptional regulatory networks in <i>Drosophila</i>
Extensive cross-regulation of post-transcriptional regulatory networks in <i>Drosophila</i> Open
In eukaryotic cells, RNAs exist as ribonucleoprotein particles (RNPs). Despite the importance of these complexes in many biological processes, including splicing, polyadenylation, stability, transportation, localization, and translation, t…
View article: Regulation of alternative splicing in <i>Drosophila</i> by 56 RNA binding proteins
Regulation of alternative splicing in <i>Drosophila</i> by 56 RNA binding proteins Open
Alternative splicing is regulated by RNA binding proteins (RBPs) that recognize pre-mRNA sequence elements and activate or repress adjacent exons. Here, we used RNA interference and RNA-seq to identify splicing events regulated by 56 Droso…