Michael S. Okun
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View article: A modified Delphi study of post-operative management for subthalamic deep brain stimulation in Parkinson's disease
A modified Delphi study of post-operative management for subthalamic deep brain stimulation in Parkinson's disease Open
Background Despite the widespread adoption of deep brain stimulation (DBS) for treating Parkinson's disease (PD) over the last few decades, standardized post-operative care protocols remain lacking. Objective This study aimed to establish …
View article: A PLAN to address the Parkinson pandemic
A PLAN to address the Parkinson pandemic Open
The Parkinson pandemic continues to spread. Almost 12 million individuals now have the disease, nearly double the estimate from just six years ago. Its human-made nature is also increasingly clear as more studies tie environmental toxicant…
View article: The <scp>CM</scp> ‐ <scp>aGPi</scp> Network in the Generation of Tics in Tourette Syndrome
The <span>CM</span> ‐ <span>aGPi</span> Network in the Generation of Tics in Tourette Syndrome Open
Background Tourette syndrome (TS) is a neurodevelopmental disorder characterized by intermittent involuntary, repetitive movements and vocalizations collectively referred to as tics. For participants with severe tics who are resistant to m…
View article: Five-Year Outcomes from Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson Disease
Five-Year Outcomes from Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson Disease Open
Importance The Implantable Neurostimulator for the Treatment of Parkinson’s Disease (INTREPID) trial was a randomized, double-blind, sham-controlled study of subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of Parki…
View article: Screening for a “trifecta” of executive function patterns in a large cohort of individuals with Parkinson’s disease
Screening for a “trifecta” of executive function patterns in a large cohort of individuals with Parkinson’s disease Open
Objective: This study examined three neurocognitive patterns or “clinical pearls” historically viewed as evidence for executive dysfunction in Parkinson disease (PD): 1) letter < category fluency; 2) word list < story delayed recall; 3) wo…
View article: Sustained Therapeutic Benefits Using Image‐Guided Programming at Activation of Deep Brain Stimulation for Parkinson's Disease
Sustained Therapeutic Benefits Using Image‐Guided Programming at Activation of Deep Brain Stimulation for Parkinson's Disease Open
Background The efficacy of deep brain stimulation (DBS) for Parkinson's disease (PD) depends on optimizing stimulation parameters for each patient, a time‐sensitive process. Image‐guided programming (IGP) offers a promising method to strea…
View article: Biomarker changes associated with fornix deep brain stimulation in Alzheimer's disease
Biomarker changes associated with fornix deep brain stimulation in Alzheimer's disease Open
INTRODUCTION Deep brain stimulation of the fornix (fx‐DBS) is being investigated for treatment of Alzheimer's disease (AD). The therapy aims at alleviating memory and cognitive circuit dysfunction. In preclinical models of AD, electrical s…
View article: A Convergent Pathway for Stimulation‐Induced Dyskinesia Following Deep Brain Stimulation
A Convergent Pathway for Stimulation‐Induced Dyskinesia Following Deep Brain Stimulation Open
Background Stimulation‐induced dyskinesias (SID) from deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) are uncommon; however, they are increasingly recognized. Once considered transient and i…
View article: Corrigendum: Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
Corrigendum: Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications Open
[This corrects the article DOI: 10.3389/fnhum.2025.1544994.].
View article: Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study
Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study Open
While conventional deep brain stimulation (cDBS) treatment delivers continuous electrical stimuli, new adaptive DBS (aDBS) technology provides dynamic symptom-related stimulation. Research data are promising, and devices are already availa…
View article: The fixel GI Parkinson's research and integrated support model (PRISM)
The fixel GI Parkinson's research and integrated support model (PRISM) Open
Background The complexity of gastrointestinal (GI) disorders associated with Parkinson's disease (PD) and the significant interactions between GI medications and the dopaminergic axis necessitates expert management. The integrated care mod…
View article: Comparative analysis of Parkinson’s and inflammatory bowel disease gut microbiomes reveals shared butyrate-producing bacteria depletion
Comparative analysis of Parkinson’s and inflammatory bowel disease gut microbiomes reveals shared butyrate-producing bacteria depletion Open
Epidemiological studies reveal that inflammatory bowel disease (IBD) is associated with an increased risk of Parkinson’s disease (PD). Gut dysbiosis has been documented in both PD and IBD, however it is currently unknown whether gut dysbio…
View article: Automated Imaging Differentiation for Parkinsonism
Automated Imaging Differentiation for Parkinsonism Open
Importance Magnetic resonance imaging (MRI) paired with appropriate disease-specific machine learning holds promise for the clinical differentiation of Parkinson disease (PD), multiple system atrophy (MSA) parkinsonian variant, and progres…
View article: The Role of a Social Worker in the Deep Brain Stimulation Preoperative Evaluation: The <scp>DBS</scp>‐<scp>FACTS</scp> Screening Tool
The Role of a Social Worker in the Deep Brain Stimulation Preoperative Evaluation: The <span>DBS</span>‐<span>FACTS</span> Screening Tool Open
Background Social workers (SW) are part of multidisciplinary teams for many surgical disciplines. Their role in deep brain stimulation (DBS) presurgical evaluations has not been defined. Objectives The goal was to characterize the role of …
View article: Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications Open
The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-ge…
View article: A prospective controlled study of a wearable rhythmic vibrotactile device for tremor in Parkinson’s disease
A prospective controlled study of a wearable rhythmic vibrotactile device for tremor in Parkinson’s disease Open
This study is one of the first controlled large sample studies to investigate how ViS may influence the objective measures of tremor in PD.
View article: Lesioning Through a Directional Deep Brain Stimulation Lead in the Subthalamic Nucleus
Lesioning Through a Directional Deep Brain Stimulation Lead in the Subthalamic Nucleus Open
Creating a lesion through a DBS lead using radiofrequency ablation is a therapeutic option for patients not interested in later re-implantation or for those with a history of multiple DBS related infections. Lesioning through segmented lea…
View article: A critical role of action-related functional networks in Gilles de la Tourette syndrome
A critical role of action-related functional networks in Gilles de la Tourette syndrome Open
Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defin…
View article: Motor outcomes in unilateral, bilateral rapid, and bilateral delayed staging deep brain stimulation for Parkinson’s disease
Motor outcomes in unilateral, bilateral rapid, and bilateral delayed staging deep brain stimulation for Parkinson’s disease Open
Background Deep brain stimulation (DBS) is effective in managing motor symptoms in select cases of Parkinson's disease (PD). Nonetheless, the ideal timing for surgery and the comparative outcomes of unilateral versus bilateral DBS procedur…
View article: A review of temporal interference, nanoparticles, ultrasound, gene therapy, and designer receptors for Parkinson disease
A review of temporal interference, nanoparticles, ultrasound, gene therapy, and designer receptors for Parkinson disease Open
In this review, we summarize preclinical and clinical trials investigating innovative neuromodulatory approaches for Parkinson disease (PD) motor symptom management. We highlight the following technologies: temporal interference, nanoparti…