Michael W. Otto
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View article: Digital Cognitive Behavioral Treatment for Generalized Anxiety Disorder
Digital Cognitive Behavioral Treatment for Generalized Anxiety Disorder Open
Importance Generalized anxiety disorder (GAD) is a chronic and disabling condition. Although cognitive behavioral therapy (CBT) is a first-line treatment for GAD, access to this treatment is limited; digital CBT (DCBT) programs may have th…
View article: Moderating Role of State and Trait Positive Affect in Virtual Reality Exposure for Public Speaking Anxiety: Protocol for a Multisite Experimental Study
Moderating Role of State and Trait Positive Affect in Virtual Reality Exposure for Public Speaking Anxiety: Protocol for a Multisite Experimental Study Open
Background The identification of moderators of exposure-based cognitive behavioral therapy (EXCBT) outcomes has the potential to (1) guide the judicious application of the limited resource that is EXCBT and (2) identify additional treatmen…
View article: Isradipine Enhancement of Virtual Reality Cue Exposure Therapy is Effective for Individuals with Higher Baseline Cue-Induced Craving
Isradipine Enhancement of Virtual Reality Cue Exposure Therapy is Effective for Individuals with Higher Baseline Cue-Induced Craving Open
Background: Evidence based treatments for smoking cessation have high relapse rates. Targeting cue-induced craving, a strong predictor of relapse, may be critical to promoting sustained abstinence. We previously found that isradipine, an F…
View article: Relative Preference for In-Person, Telehealth, Digital, and Pharmacologic Mental Health Care After the COVID-19 Pandemic: Cross-Sectional Questionnaire Study
Relative Preference for In-Person, Telehealth, Digital, and Pharmacologic Mental Health Care After the COVID-19 Pandemic: Cross-Sectional Questionnaire Study Open
Background Most adults and children in the United States fail to receive timely care for mental health symptoms, with even worse rates of care access for individuals who belong to racial and ethnic minority groups. Digital (ie, app-based) …
View article: Mechanisms of Change in Exposure Therapy for Anxiety and Related Disorders: A Research Agenda
Mechanisms of Change in Exposure Therapy for Anxiety and Related Disorders: A Research Agenda Open
Anxiety and related disorders are a significant public-health burden with rising prevalence in the wake of the COVID-19 pandemic. As demand for effective anxiety treatment increases, so too does the need for strategies to bolster treatment…
View article: Cost-effectiveness of automated digital CBT (Daylight) for generalized anxiety disorder: A Markov simulation model in the United States
Cost-effectiveness of automated digital CBT (Daylight) for generalized anxiety disorder: A Markov simulation model in the United States Open
This study examines the cost-effectiveness and cost-benefit of a fully automated smartphone-delivered digital cognitive behavioral therapy (CBT) intervention for Generalized Anxiety Disorder (GAD). In a simulated Markov model, 100,000 indi…
View article: Going Beyond Trauma: A Scoping Review on the Prevalence of Symptom-Relevant Negative Autobiographical Memories in Anxiety Disorders and Obsessive-Compulsive Disorder
Going Beyond Trauma: A Scoping Review on the Prevalence of Symptom-Relevant Negative Autobiographical Memories in Anxiety Disorders and Obsessive-Compulsive Disorder Open
Although negative autobiographical memories play a defined etiological role for trauma-related disorders, it is less clear what role they play in other anxiety-related disorders. Understanding the prevalence of negative autobiographical me…
View article: Fear attenuation collaborations to optimize translation.
Fear attenuation collaborations to optimize translation. Open
Here, we describe the efforts we dedicated to the challenge of modifying entrenched emotionally laden memories. In recent years, through a number of collaborations and using a combination of behavioral, molecular, and computational approac…
View article: Mechanisms of Change in Exposure Therapy for Anxiety and Related Disorders: A Research Agenda
Mechanisms of Change in Exposure Therapy for Anxiety and Related Disorders: A Research Agenda Open
Anxiety and related disorders are a significant public-health burden with rising prevalence in the wake of the COVID-19 pandemic. As demand for effective anxiety treatment increases, so too does the need for strategies to bolster treatment…
View article: Recurrent Negative Autobiographical Memories and Mental Health
Recurrent Negative Autobiographical Memories and Mental Health Open
Background: Recurrent symptom-relevant negative autobiographical memories are common in patients with emotional disorders such as anxiety and depression, even among those without a trauma-related diagnosis. Recurrent negative autobiographi…
View article: A Proposed Definition of Psychological Treatment and Its Relation to Empirically Supported Treatments
A Proposed Definition of Psychological Treatment and Its Relation to Empirically Supported Treatments Open
This article describes the work of a task force, commissioned by the American Psychological Association’s Society of Clinical Psychology (SCP), to define “psychological treatment.” We discuss SCP’s rationale for needing such a definition, …
View article: The Role of Functional Health Literacy in terms of Harmful Alcohol Use in Adults with Probable Posttraumatic Stress Disorder and Alcohol Use Disorder
The Role of Functional Health Literacy in terms of Harmful Alcohol Use in Adults with Probable Posttraumatic Stress Disorder and Alcohol Use Disorder Open
Purpose The current study examined functional health literacy (FHL) in regard to hazardous drinking among a sample with probable posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Methods Participants were 565 adults with…
View article: Carbon Dioxide Reactivity Differentially Predicts Fear Expression After Extinction and Retrieval-Extinction in Rats
Carbon Dioxide Reactivity Differentially Predicts Fear Expression After Extinction and Retrieval-Extinction in Rats Open
CO2 reactivity could be used as a screening tool to determine whether an individual may be a good candidate for an extinction-based therapeutic approach.
View article: Isradipine augmentation of virtual reality cue exposure therapy for tobacco craving: a triple-blind randomized controlled trial
Isradipine augmentation of virtual reality cue exposure therapy for tobacco craving: a triple-blind randomized controlled trial Open
Preclinical research with rodents suggests that the L-type calcium channel blocker isradipine can enhance long-term extinction of conditioned place preference for addictive substances when it is administered in conjunction with extinction …
View article: Isradipine augmentation of virtual reality cue exposure therapy for tobacco craving: a triple-blind randomized controlled trial
Isradipine augmentation of virtual reality cue exposure therapy for tobacco craving: a triple-blind randomized controlled trial Open
Preclinical research with rodents suggests that the L-type calcium channel blocker isradipine can enhance long-term extinction of conditioned place preference for addictive substances when it is administered in conjunction with extinction …
View article: Relative Preference for In-Person, Telehealth, Digital, and Pharmacologic Mental Health Care After the COVID-19 Pandemic: Cross-Sectional Questionnaire Study (Preprint)
Relative Preference for In-Person, Telehealth, Digital, and Pharmacologic Mental Health Care After the COVID-19 Pandemic: Cross-Sectional Questionnaire Study (Preprint) Open
BACKGROUND Most adults and children in the United States fail to receive timely care for mental health symptoms, with even worse rates of care access for individuals who belong to racial and ethnic minority groups. Digital (ie, app-based)…