Michael Owston
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View article: Histological variation of early stage atherosclerotic lesions in baboons after prolonged challenge with high‐cholesterol, high‐fat diet
Histological variation of early stage atherosclerotic lesions in baboons after prolonged challenge with high‐cholesterol, high‐fat diet Open
Introduction The baboon is a well‐characterized model of human early stage atherosclerosis. However, histological and morphological changes involved in atherogenesis in baboons are not known. Previously, we challenged baboons with a high‐c…
View article: Cutaneous epitheliotropic lymphoma in a baboon (<i>Papio</i>spp<i>.</i>): A case report and a brief literature review
Cutaneous epitheliotropic lymphoma in a baboon (<i>Papio</i>spp<i>.</i>): A case report and a brief literature review Open
Cutaneous epitheliotropic lymphoma (CEL) has not been reported in non‐human primates. We report the first case of CEL in a 9‐year‐old baboon. The phenotype of the neoplastic cells in this baboon is similar to CEL in humans (CD3+, CD4+, CD8…
View article: Coccidioidomycosis in Nonhuman Primates: Pathologic and Clinical Findings
Coccidioidomycosis in Nonhuman Primates: Pathologic and Clinical Findings Open
Coccidioidomycosis in nonhuman primates has been sporadically reported in the literature. This study describes 22 cases of coccidioidomycosis in nonhuman primates within an endemic region, and 79 cases of coccidioidomycosis from the veteri…
View article: Phylogenetic analysis of Histoplasma capsulatum var duboisii in baboons from archived formalin-fixed, paraffin embedded tissues
Phylogenetic analysis of Histoplasma capsulatum var duboisii in baboons from archived formalin-fixed, paraffin embedded tissues Open
Histoplasma capsulatum var. duboisii (Hcd) infections have been well documented to cause chronic granulomatous disease, mainly involving the skin of baboons and humans in African countries primarily. This retrospective study classified the…
View article: Cytomegaloviral hypophysitis in a simian immunodeficiency virus‐infected rhesus macaque (<i>Macacca mulatta</i>)
Cytomegaloviral hypophysitis in a simian immunodeficiency virus‐infected rhesus macaque (<i>Macacca mulatta</i>) Open
Rhesus macaques experimentally infected with Simian Immunodeficiency Virus ( SIV ) experience immunosuppression and often opportunistic infection. Among the most common opportunistic infections are rhesus cytomegalovirus (Rh CMV ), a ubiqu…
View article: Diet‐induced early‐stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance
Diet‐induced early‐stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance Open
Background The purpose of this study was to determine whether dietary manipulation can reliably induce early‐stage atherosclerosis and clinically relevant changes in vascular function in an established, well‐characterized non‐human primate…
View article: Spontaneous mediastinal myeloid sarcoma in a common marmoset (<i>Callithrix jacchus</i>) and review of the veterinary literature
Spontaneous mediastinal myeloid sarcoma in a common marmoset (<i>Callithrix jacchus</i>) and review of the veterinary literature Open
Background Myeloid sarcoma is a rare manifestation of myeloproliferative disorder defined as an extramedullary mass composed of myeloid precursor cells. A 9‐month old, female, common marmoset ( Callithrix jacchus ) had increased respirator…
View article: Pauci‐immune glomerulonephritis in a captive chimpanzee (<i>Pan troglodytes</i>), and a review of spontaneous cases in animals
Pauci‐immune glomerulonephritis in a captive chimpanzee (<i>Pan troglodytes</i>), and a review of spontaneous cases in animals Open
Background Crescentic glomeruli are the hallmark finding in rapidly progressive glomerulonephritis ( RPGN ) and are characterized by disruption and proliferation of the glomerular capsule and an influx of cells into Bowman's space. Pauci‐i…
View article: Pancreatic neuroendocrine tumors in twelve baboons (<i>Papio</i> spp.)
Pancreatic neuroendocrine tumors in twelve baboons (<i>Papio</i> spp.) Open
Background Pancreatic neuroendocrine tumors ( PNET s) are rare in nonhuman primates and in humans. Methods Twenty‐one PNET s from twelve female baboons ( Papio spp.) from the Southwest National Primate Research Center were evaluated using …
View article: An efficient model of human endometriosis by induced unopposed estrogenicity in baboons
An efficient model of human endometriosis by induced unopposed estrogenicity in baboons Open
Endometriosis is a chronic estrogen-dependent disease that occurs in approximately 10% of reproductive age women. Baboons offer a clear benefit for studying the initiation and progression of endometriosis since baboon is very close to huma…
View article: Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees
Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees Open
Chimpanzees ( Pan troglodytes) have served as an important model for studies of reproductive diseases and aging-related disorders in humans. However, limited information is available about spontaneously occurring reproductive tract lesions…
View article: Particle-to-PFU Ratio of Ebola Virus Influences Disease Course and Survival in Cynomolgus Macaques
Particle-to-PFU Ratio of Ebola Virus Influences Disease Course and Survival in Cynomolgus Macaques Open
This study addresses the role of Ebola virus (EBOV) specific infectivity in virulence. Filoviruses are highly lethal, enveloped, single-stranded negative-sense RNA viruses that can cause hemorrhagic fever. No approved vaccines or therapies…
View article: Osteosarcoma in Baboons (Papio spp).
Osteosarcoma in Baboons (Papio spp). Open
Bone neoplasms in baboons (Papio spp) are rare, with only one confirmed case of osteosarcoma previously described in the literature. Over a 12-y period, 6 baboons at a national primate research center presented with naturally occurring ost…