Michael P. Bokoch
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View article: Microbial and host inflammatory factors induce permeability and activate cytokine production by human glomerular microvascular endothelial cells
Microbial and host inflammatory factors induce permeability and activate cytokine production by human glomerular microvascular endothelial cells Open
View article: Ultrasound-based assessment of muscle mass is associated with early recovery after kidney transplant: a prospective single-center study
Ultrasound-based assessment of muscle mass is associated with early recovery after kidney transplant: a prospective single-center study Open
View article: Vasopressin Is Not Associated With Severe Kidney Injury in Liver Transplantation: A Propensity Score-adjusted Analysis
Vasopressin Is Not Associated With Severe Kidney Injury in Liver Transplantation: A Propensity Score-adjusted Analysis Open
Background. Hypotension during liver transplantation often requires vasopressor therapy. Acute kidney injury is a common complication after liver transplantation. Vasopressin acts as a portal flow modulator, may increase the glomerular fil…
View article: Serum from patients with cirrhosis undergoing liver transplantation induces permeability in human pulmonary microvascular endothelial cells ex vivo
Serum from patients with cirrhosis undergoing liver transplantation induces permeability in human pulmonary microvascular endothelial cells ex vivo Open
Introduction Patients with cirrhosis undergoing liver transplantation frequently exhibit systemic inflammation, coagulation derangements, and edema, indicating endothelial dysfunction. This syndrome may worsen after ischemia–reperfusion in…
View article: Vasopressin Use During Liver Transplantation Is Not Associated with Severe Acute Kidney Injury: A Propensity Score Adjusted Regression Analysis v1
Vasopressin Use During Liver Transplantation Is Not Associated with Severe Acute Kidney Injury: A Propensity Score Adjusted Regression Analysis v1 Open
Acute kidney injury is a common complication after liver transplantation. Acute kidney injury occurrence in this population determines higher mortality, increased graft loss, longer hospital and intensive care unit stays, and more progress…
View article: ECIS Data Analysis for Stimulation of Human Pulmonary Microvascular Endothelial Cells (HPMECs) with Human Serum v2
ECIS Data Analysis for Stimulation of Human Pulmonary Microvascular Endothelial Cells (HPMECs) with Human Serum v2 Open
Sera from patients in our UCSF Liver Transplant Biobank are used to stimulate human pulmonary microvascular endothelial cells (HPMECs) grown to confluency on ECIS platform. This protocol prospectively defines the plan for data analysis fro…
View article: Goal-Directed Therapy in Liver Surgery
Goal-Directed Therapy in Liver Surgery Open
Purpose of Review This review summarizes the updated literature on goal-directed therapy during liver surgery. It provides guidance for clinicians regarding physiologic concepts and clinical evidence related to fluid and hemodynamic manage…
View article: Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial
Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial Open
NCT04789330.
View article: ECIS Data Analysis for Stimulation of Human Pulmonary Microvascular Endothelial Cells (HPMECs) with Human Serum v2
ECIS Data Analysis for Stimulation of Human Pulmonary Microvascular Endothelial Cells (HPMECs) with Human Serum v2 Open
Sera from patients in our UCSF Liver Transplant Biobank are used to stimulate human pulmonary microvascular endothelial cells (HPMECs) grown to confluency on ECIS platform. This protocol prospectively defines the plan for data analysis fro…
View article: ECIS Data Analysis for Stimulation of Human Pulmonary Microvascular Endothelial Cells (HPMECs) with Human Serum v3
ECIS Data Analysis for Stimulation of Human Pulmonary Microvascular Endothelial Cells (HPMECs) with Human Serum v3 Open
Sera from patients in our UCSF Liver Transplant Biobank are used to stimulate human pulmonary microvascular endothelial cells (HPMECs) grown to confluency on ECIS platform. This protocol prospectively defines the plan for data analysis fro…
View article: Angiotensin II in liver transplantation (AngLT-1): protocol of a randomised, double-blind, placebo-controlled trial
Angiotensin II in liver transplantation (AngLT-1): protocol of a randomised, double-blind, placebo-controlled trial Open
Introduction Catecholamine vasopressors such as norepinephrine are the standard drugs used to maintain mean arterial pressure during liver transplantation. At high doses, catecholamines may impair organ perfusion. Angiotensin II is a pepti…
View article: Lactate concentration at the end of liver transplant: Early predictor of graft function or just one piece of the puzzle?
Lactate concentration at the end of liver transplant: Early predictor of graft function or just one piece of the puzzle? Open
Background The post‐operative course after Liver Transplantation (LT) can be complicated by early allograft dysfunction (EAD), primary nonfunction (PNF) and death. A lactate concentration at the end of transplant of ≥5 mmol/L was recently …
View article: Real‐world implementation of normothermic machine perfusion: A detailed analysis of intraoperative and early postoperative impact
Real‐world implementation of normothermic machine perfusion: A detailed analysis of intraoperative and early postoperative impact Open
Background Outcome data for the great majority of liver normothermic machine perfusion (NMP) cases derive from the strict confines of clinical trials. Detailed specifics regarding the intraoperative and early postoperative impact of NMP on…
View article: Norepinephrine versus phenylephrine for treating hypotension during general anaesthesia in adult patients undergoing major noncardiac surgery: a multicentre, open-label, cluster-randomised, crossover, feasibility, and pilot trial
Norepinephrine versus phenylephrine for treating hypotension during general anaesthesia in adult patients undergoing major noncardiac surgery: a multicentre, open-label, cluster-randomised, crossover, feasibility, and pilot trial Open
NCT04789330 (ClinicalTrials.gov).
View article: Intraoperative Use of Albumin in Major Noncardiac Surgery: Incidence, Variability, and Association With Outcomes
Intraoperative Use of Albumin in Major Noncardiac Surgery: Incidence, Variability, and Association With Outcomes Open
Background: The impact of albumin use during major surgery is unknown, and a dearth of evidence governing its use in major noncardiac surgery has long precluded its standardization in clinical guidelines. Objective: In this study, we inves…
View article: Optimizing the Design and Analysis of Future AKI Trials
Optimizing the Design and Analysis of Future AKI Trials Open
AKI is a complex clinical syndrome associated with an increased risk of morbidity and mortality, particularly in critically ill and perioperative patient populations. Most AKI clinical trials have been inconclusive, failing to detect clini…
View article: The Yin and Yang of the Renin–Angiotensin–Aldosterone System in Acute Kidney Injury
The Yin and Yang of the Renin–Angiotensin–Aldosterone System in Acute Kidney Injury Open
View article: Mild Hypothermia to prevent Acute kidney injury in Liver Transplantation (MHALT) Trial - Statistical Analysis Plan for the Interim Analysis, v1.0 v1
Mild Hypothermia to prevent Acute kidney injury in Liver Transplantation (MHALT) Trial - Statistical Analysis Plan for the Interim Analysis, v1.0 v1 Open
Acute kidney injury (AKI), or worsening kidney function, is a common complication after liver transplantation (20-90% in published studies). Patients who experience AKI after liver transplantation have higher mortality, increased graft los…
View article: Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery?
Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery? Open
View article: Central Venous Catheter in the Internal Mammary Vein
Central Venous Catheter in the Internal Mammary Vein Open
View article: Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule
Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule Open
The pathways that G protein-coupled receptor (GPCR) ligands follow as they bind to or dissociate from their receptors are largely unknown. Protease-activated receptor-1 (PAR1) is a GPCR activated by intramolecular binding of a tethered ago…
View article: Entry from the Lipid Bilayer: A Novel Pathway for Inhibition of a Peptide G-Protein Coupled Receptor by a Lipophilic Small Molecule
Entry from the Lipid Bilayer: A Novel Pathway for Inhibition of a Peptide G-Protein Coupled Receptor by a Lipophilic Small Molecule Open