Michael P. Carty
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View article: Canonical and Non-Canonical Roles of Human DNA Polymerase η
Canonical and Non-Canonical Roles of Human DNA Polymerase η Open
DNA damage tolerance pathways that allow for the completion of replication following fork arrest are critical in maintaining genome stability during cell division. The main DNA damage tolerance pathways include strand switching, replicatio…
View article: Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis
Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis Open
This review uses the National Cancer Institute (NCI) COMPARE program to establish an extensive list of heterocyclic iminoquinones and quinones with similarities in differential growth inhibition patterns across the 60-cell line panel of th…
View article: Heterocyclic Iminoquinones and Quinones from National Cancer Institute (NCI, USA) COMPARE Analysis
Heterocyclic Iminoquinones and Quinones from National Cancer Institute (NCI, USA) COMPARE Analysis Open
This review uses the National Cancer Institute (NCI) COMPARE program to establish an extensive list of heterocyclic iminoquinones and quinones with similarities in differential growth inhibition across the 60-cell line panel of the NCI Dev…
View article: DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target
DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target Open
DNA lesions arising from both exogenous and endogenous sources occur frequently in DNA. During DNA replication, the presence of unrepaired DNA damage in the template can arrest replication fork progression, leading to fork collapse, double…
View article: A biocompatible ZnNa<sub>2</sub>-based metal–organic framework with high ibuprofen, nitric oxide and metal uptake capacity
A biocompatible ZnNa<sub>2</sub>-based metal–organic framework with high ibuprofen, nitric oxide and metal uptake capacity Open
The synthesis and characterization of a mixed metal ZnNa2 MOF (NUIG1) is discussed; NUIG1 displays a new framework topology, and possesses an exceptionally high drug adsorption capacity and metal encapsulation potential.
View article: VIS: the visible imager for Euclid
VIS: the visible imager for Euclid Open
Euclid-VIS is the large format visible imager for the ESA Euclid space mission in their Cosmic Vision program, scheduled for launch in 2021. Together with the near infrared imaging within the NISP instrument, it forms the basis of the weak…
View article: Anti-Cancer Activity of Phenyl and Pyrid-2-yl 1,3-Substituted Benzo[1,2,4]triazin-7-ones and Stable Free Radical Precursors
Anti-Cancer Activity of Phenyl and Pyrid-2-yl 1,3-Substituted Benzo[1,2,4]triazin-7-ones and Stable Free Radical Precursors Open
Cell viability studies for benzo[1,2,4]triazin-7-ones and 1,2,4-benzotriazinyl (Blatter-type) radical precursors are described with comparisons made with 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO). All of the stable free radicals were se…
View article: CCDC 1830483: Experimental Crystal Structure Determination
CCDC 1830483: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1830485: Experimental Crystal Structure Determination
CCDC 1830485: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1830484: Experimental Crystal Structure Determination
CCDC 1830484: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …