Michael P. Franczyk
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View article: Adipocyte-specific inactivation of NAMPT, a key NAD<sup>+</sup> biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging
Adipocyte-specific inactivation of NAMPT, a key NAD<sup>+</sup> biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging Open
Defective NAD + metabolism is associated with aging and age-associated metabolic diseases. In the present study, we provided in-depth metabolic assessments in female mice with adipocyte-specific inactivation of a key NAD + biosynthetic enz…
View article: SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase
SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase Open
View article: Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women Open
Anti-aging supplement effects in humans Synthesis of nicotinamide adenine dinucleotide (NAD + ) decreases during aging, which is thought to limit the activity of enzymes that require it for their catalytic activity. Studies in animals indi…
View article: Removal of Epididymal Visceral Adipose Tissue Prevents Obesity-Induced Multi-organ Insulin Resistance in Male Mice
Removal of Epididymal Visceral Adipose Tissue Prevents Obesity-Induced Multi-organ Insulin Resistance in Male Mice Open
Obesity is associated with insulin resistance, an important risk factor of type 2 diabetes, atherogenic dyslipidemia, and nonalcoholic fatty liver disease. The major purpose of this study was to test hypothesize that prophylactic removal o…
View article: Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility
Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility Open
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme that regulates cellular energy metabolism in many cell types. The major purpose of the present study was to test the hypothesis that NAD+ in white adipose tissue (WAT) is a …
View article: Adipose tissue NAD <sup>+</sup> biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice
Adipose tissue NAD <sup>+</sup> biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice Open
Nicotinamide adenine dinucleotide (NAD + ) is a critical coenzyme for cellular energy metabolism. The aim of the present study was to determine the importance of brown and white adipose tissue (BAT and WAT) NAD + metabolism in regulating w…
View article: Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans
Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans Open
View article: NAD<sup>+</sup>-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism
NAD<sup>+</sup>-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism Open
Mitochondrial dysfunction in adipose tissue is involved in the pathophysiology of obesity-induced systemic metabolic complications, such as type 2 diabetes, insulin resistance, and dyslipidemia. However, the mechanisms responsible for obes…
View article: Diurnal Variation in PDK4 Expression Is Associated With Plasma Free Fatty Acid Availability in People
Diurnal Variation in PDK4 Expression Is Associated With Plasma Free Fatty Acid Availability in People Open
Our results suggest that plasma FFA availability is an important regulator of diurnal expression patterns of PDK4, and we identify a novel interaction between plasma FFA and cellular diurnal rhythms in regulating substrate metabolism.
View article: NAMPT-Mediated NAD+ Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice
NAMPT-Mediated NAD+ Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice Open