Michael P. Hendrich
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View article: Reactivity of canonical bacterial cytochrome <i>c</i> peroxidases: insights into the electronic structure of compound I
Reactivity of canonical bacterial cytochrome <i>c</i> peroxidases: insights into the electronic structure of compound I Open
Bacterial cytochrome c peroxidase (bCcP) family members include di-heme enzymes that are capable of producing various high oxidation states in their reactions with the substrate H 2 O 2 .
View article: Detection and characterization of a compound 1 species from the <i>c</i> -type heme enzyme cytochrome <i>c</i> ′ <sub>β</sub>
Detection and characterization of a compound 1 species from the <i>c</i> -type heme enzyme cytochrome <i>c</i> ′ <sub>β</sub> Open
Cytochrome c ′ β of the ammonia-oxidizing bacterium Nitrosomonas europaea is an enzyme containing heme c and a member of the P460 superfamily. During reaction with H 2 O 2 a key intermediate, compound 1, was trapped and spectroscopically c…
View article: Enhanced Proton-Coupled Electron-Transfer Reactivity by a Mononuclear Nickel(II) Hydroxide Radical Complex
Enhanced Proton-Coupled Electron-Transfer Reactivity by a Mononuclear Nickel(II) Hydroxide Radical Complex Open
The synthesis, characterization, and reactivity of a NiOH core bearing a tridentate redox-active ligand capable of reaching three molecular oxidation states is presented in this paper. The reduced complex [LNiOH]2- was character…
View article: Synthesis, characterization and reactivity of a Mn(III)–hydroxido complex as a biomimetic model for lipoxygenase
Synthesis, characterization and reactivity of a Mn(III)–hydroxido complex as a biomimetic model for lipoxygenase Open
View article: Mimicking the Reactivity of LPMOs with a Mononuclear Cu Complex
Mimicking the Reactivity of LPMOs with a Mononuclear Cu Complex Open
Lytic polysaccharide monooxygenases (LPMOs) are Cu‐dependent metalloenzymes that catalyze the hydroxylation of strong C−H bonds in polysaccharides using O 2 or H 2 O 2 as oxidants (monooxygenase/peroxygenase). In the absence of C−H substra…
View article: CCDC 2291043: Experimental Crystal Structure Determination
CCDC 2291043: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2291042: Experimental Crystal Structure Determination
CCDC 2291042: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2291041: Experimental Crystal Structure Determination
CCDC 2291041: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Accessing a synthetic Fe<sup>III</sup>Mn<sup>IV</sup> core to model biological heterobimetallic active sites
Accessing a synthetic Fe<sup>III</sup>Mn<sup>IV</sup> core to model biological heterobimetallic active sites Open
Characterization of a synthetic mimic for an enzymatic Fe III Mn IV intermediate and its reactivity with phenolic substrates.
View article: Modulation of the Bonding between Copper and a Redox-Active Ligand by Hydrogen Bonds and Its Effect on Electronic Coupling and Spin States
Modulation of the Bonding between Copper and a Redox-Active Ligand by Hydrogen Bonds and Its Effect on Electronic Coupling and Spin States Open
The exchange coupling of electron spins can strongly influence the properties of chemical species. The regulation of this type of electronic coupling has been explored within complexes that have multiple metal ions but to a lesser extent i…
View article: Influence of the ligand-field on EPR parameters of cis- and trans-isomers in MoV systems relevant to molybdenum enzymes: Experimental and density functional theory study
Influence of the ligand-field on EPR parameters of cis- and trans-isomers in MoV systems relevant to molybdenum enzymes: Experimental and density functional theory study Open
View article: The Mechanism of Formation of Active Fe-TAMLs Using HClO Enlightens Design for Maximizing Catalytic Activity at Environmentally Optimal, Circumneutral pH
The Mechanism of Formation of Active Fe-TAMLs Using HClO Enlightens Design for Maximizing Catalytic Activity at Environmentally Optimal, Circumneutral pH Open
Fe-TAML/peroxide catalysis provides simple, powerful, ultradilute approaches for removing micropollutants from water. The typically rate-determining interactions of H2O2 with Fe-TAMLs (rate constant kI
View article: CCDC 2173659: Experimental Crystal Structure Determination
CCDC 2173659: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2173660: Experimental Crystal Structure Determination
CCDC 2173660: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A 4H<sup>+</sup>/4e<sup>–</sup> Electron-Coupled-Proton Buffer Based on a Mononuclear Cu Complex
A 4H<sup>+</sup>/4e<sup>–</sup> Electron-Coupled-Proton Buffer Based on a Mononuclear Cu Complex Open
In this research article, we describe a 4H+/4e- electron-coupled-proton buffer (ECPB) based on Cu and a redox-active ligand. The protonated/reduced ECPB (complex 1: [Cu(8H+/14e-)]1…
View article: Preface
Preface Open
This textbook is an introduction to the theory and techniques of Electron Paramagnetic Resonance (EPR).It is intended for advanced undergraduate and beginning graduate students who are first learning about EPR.It is by no means an exhausti…
View article: Bioinspired Di-Fe Complexes: Correlating Structure and Proton Transfer over Four Oxidation States
Bioinspired Di-Fe Complexes: Correlating Structure and Proton Transfer over Four Oxidation States Open
Metalloproteins with active sites containing di-Fe cores exhibit diverse chemical reactivity that is linked to the precise transfer of protons and electrons which directly involve the di-Fe units. The redox conversions are commonly corrobo…
View article: Retraction Note: Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme
Retraction Note: Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme Open
View article: Artificial Metalloproteins with Dinuclear Iron–Hydroxido Centers
Artificial Metalloproteins with Dinuclear Iron–Hydroxido Centers Open
Dinuclear iron centers with a bridging hydroxido or oxido ligand form active sites within a variety of metalloproteins. A key feature of these sites is the ability of the protein to control the structures around the Fe centers, which leads…
View article: Stepwise assembly of heterobimetallic complexes: synthesis, structure, and physical properties
Stepwise assembly of heterobimetallic complexes: synthesis, structure, and physical properties Open
An FeIII–OH synthon is utilized to promote the assembly of heterobimetallic complexes with a bridging hydroxido ligand.
View article: Kinetic and Spectroscopic Characterization of the Catalytic Ternary Complex of Tryptophan 2,3-Dioxygenase
Kinetic and Spectroscopic Characterization of the Catalytic Ternary Complex of Tryptophan 2,3-Dioxygenase Open
The first step of the kynurenine pathway for l-tryptophan (l-Trp) degradation is catalyzed by heme-dependent dioxygenases, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase. In this work, we employed stopped-flow optical abs…
View article: Electronic State of the His/Tyr-Ligated Heme of BthA by Mössbauer and DFT Analysis
Electronic State of the His/Tyr-Ligated Heme of BthA by Mössbauer and DFT Analysis Open
The BthA protein from the microorganism Burkholderia thailandensis contains two hemes with axial His/OH2 and His/Tyr coordinations separated by the closest interheme distance of 14 Å. BthA has a similar structure and belo…
View article: A Stable Ferryl Porphyrin at the Active Site of Y463M BthA
A Stable Ferryl Porphyrin at the Active Site of Y463M BthA Open
BthA is a diheme enzyme that is a member of the bacterial cytochrome c peroxidase superfamily, capable of generating a highly unusual Fe(IV)Fe(IV)═O oxidation state, known to be responsible for long-range oxidative chemistry in the enzyme …
View article: Effects of Noncovalent Interactions on High-Spin Fe(IV)–Oxido Complexes
Effects of Noncovalent Interactions on High-Spin Fe(IV)–Oxido Complexes Open
High-valent nonheme FeIV-oxido species are key intermediates in biological oxidation, and their properties are proposed to be influenced by the unique microenvironments present in protein active sites. Microenvironments are regu…
View article: CCDC 1952036: Experimental Crystal Structure Determination
CCDC 1952036: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1952037: Experimental Crystal Structure Determination
CCDC 1952037: Experimental Crystal Structure Determination Open
View article: CCDC 1952035: Experimental Crystal Structure Determination
CCDC 1952035: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Tuning the Copper(II)/Copper(I) Redox Potential for More Robust Copper‐Catalyzed C–N Bond Forming Reactions
Tuning the Copper(II)/Copper(I) Redox Potential for More Robust Copper‐Catalyzed C–N Bond Forming Reactions Open
Complexes of copper and 1,10‐phenanthroline have been utilized for organic transformations over the last 50 years. In many cases these systems are impacted by reaction conditions and perform best under an inert atmosphere. Here we explore …
View article: Outer-Sphere Tyrosine 159 within the 3-Mercaptopropionic Acid Dioxygenase S-H-Y Motif Gates Substrate-Coordination Denticity at the Non-Heme Iron Active Site
Outer-Sphere Tyrosine 159 within the 3-Mercaptopropionic Acid Dioxygenase S-H-Y Motif Gates Substrate-Coordination Denticity at the Non-Heme Iron Active Site Open
Thiol dioxygenases are non-heme mononuclear iron enzymes that catalyze the O2-dependent oxidation of free thiols (-SH) to produce the corresponding sulfinic acid (-SO2-). Regardless of the phylogenic domain…
View article: CCDC 1521354: Experimental Crystal Structure Determination
CCDC 1521354: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …