Michael P. Murrell
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View article: Caging of membrane-to-cortex attachment proteins can trigger cellular symmetry breaking
Caging of membrane-to-cortex attachment proteins can trigger cellular symmetry breaking Open
SUMMARY To migrate, divide, and change shape, cells must regulate the mechanics of their periphery. The cell surface is a complex structure that consists of a thin, contractile cortical actin network tethered to the plasma membrane by spec…
View article: Active tension and membrane friction mediate cortical flows and blebbing in a model actomyosin cortex
Active tension and membrane friction mediate cortical flows and blebbing in a model actomyosin cortex Open
Blebs, spherical membrane bulges of the cell membrane, are ubiquitous structures observed in various biological phenomena, including apoptosis, cell division, to bleb-based cell migration. The mechanics of blebbing have been characterized …
View article: Growth‐induced collective bending and kinetic trapping of cytoskeletal filaments
Growth‐induced collective bending and kinetic trapping of cytoskeletal filaments Open
Growth and turnover of actin filaments play a crucial role in the construction and maintenance of actin networks within cells. Actin filament growth occurs within limited space and finite subunit resources in the actin cortex. To understan…
View article: Energy partitioning in the cell cortex
Energy partitioning in the cell cortex Open
Living systems are driven far from thermodynamic equilibrium through the continuous consumption of ambient energy 1 . In the cell cortex, this energy is invested in the formation of diverse patterns in chemical and mechanical activities, w…
View article: Elastocapillary effects determine early matrix deformation by glioblastoma cell spheroids
Elastocapillary effects determine early matrix deformation by glioblastoma cell spheroids Open
During cancer pathogenesis, cell-generated mechanical stresses lead to dramatic alterations in the mechanical and organizational properties of the extracellular matrix (ECM). To date, contraction of the ECM is largely attributed to local m…
View article: Confinement induces internal flows in adherent cell aggregates
Confinement induces internal flows in adherent cell aggregates Open
During mesenchymal migration, F-actin protrusion at the leading edge and actomyosin contraction determine the retrograde flow of F-actin within the lamella. The coupling of this flow to integrin-based adhesions determines the force transmi…
View article: Growth-induced collective bending and kinetic trapping of cytoskeletal filaments
Growth-induced collective bending and kinetic trapping of cytoskeletal filaments Open
Growth and turnover of actin filaments play a crucial role in the construction and maintenance of actin networks within cells. Actin filament growth occurs within limited space and finite subunit resources in the actin cortex. To understan…
View article: Actin and Microtubules Position Stress Granules
Actin and Microtubules Position Stress Granules Open
Novel analysis tools reveal that stress granules show different affinities to filamentous actin and microtubules, leading to robust stress granule positioning through coupling to actin flow and wetting of microtubules.
View article: Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton
Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton Open
The filamentous actin (F-actin) cytoskeleton is a composite material consisting of cortical actin and bundled F-actin stress fibers, which together mediate the mechanical behaviors of the cell, from cell division to cell migration. However…
View article: SPAK-dependent cotransporter activity mediates capillary adhesion and pressure during glioblastoma migration in confined spaces
SPAK-dependent cotransporter activity mediates capillary adhesion and pressure during glioblastoma migration in confined spaces Open
The invasive potential of glioblastoma cells is attributed to large changes in pressure and volume, driven by diverse elements, including the cytoskeleton and ion cotransporters. However, how the cell actuates changes in pressure and volum…
View article: Actin and microtubules position stress granules
Actin and microtubules position stress granules Open
Membraneless organelles, composed of protein and nucleic acids, alter the biochemical and physical landscape of the cell. While specific membraneless organelles are found in stereotypical locations, little is known about the physical mecha…
View article: Cell-Matrix Elastocapillary Interactions Drive Pressure-Based Wetting of Cell Aggregates
Cell-Matrix Elastocapillary Interactions Drive Pressure-Based Wetting of Cell Aggregates Open
Cell-matrix interfacial energies and the energies of matrix deformations may be comparable on cellular length-scales, yet how capillary effects influence tis sue shape and motion are unknown. In this work, we induce wetting (spreading and …
View article: Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading
Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading Open
Coordinated and cooperative motion of cells is essential for embryonic development, tissue morphogenesis, wound healing and cancer invasion. A predictive understanding of the emergent mechanical behaviors in collective cell motion is chall…
View article: Erratum: Bridging particle deformability and collective response in soft solids [Phys. Rev. Materials <b>5</b>, 055605 (2021)]
Erratum: Bridging particle deformability and collective response in soft solids [Phys. Rev. Materials <b>5</b>, 055605 (2021)] Open
Received 25 March 2022DOI:https://doi.org/10.1103/PhysRevMaterials.6.059901©2022 American Physical SocietyPhysics Subject Headings (PhySH)Research AreasCollective behaviorJammingPhysical SystemsEmulsionsFoamsTissuesTechniquesMolecular dyna…
View article: Gradients in solid surface tension drive Marangoni-like motions in cell aggregates
Gradients in solid surface tension drive Marangoni-like motions in cell aggregates Open
The surface tension of living cells and tissues originates from the generation of nonequilibrium active stresses within the cell cytoskeleton. Here, using laser ablation, we generate gradients in the surface tension of cellular aggregates …
View article: Correction: The structural, vibrational, and mechanical properties of jammed packings of deformable particles in three dimensions
Correction: The structural, vibrational, and mechanical properties of jammed packings of deformable particles in three dimensions Open
Correction for ‘The structural, vibrational, and mechanical properties of jammed packings of deformable particles in three dimensions’ by Dong Wang et al. , Soft Matter , 2021, 17 , 9901–9915, DOI: 10.1039/D1SM01228B.
View article: Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading
Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading Open
Using a cell-based computational model of a spreading cell monolayer, we show that the interplay between tissue fluidity and substrate rigidity regulates the rate of collective spreading.
View article: The structural, vibrational, and mechanical properties of jammed packings of deformable particles in three dimensions
The structural, vibrational, and mechanical properties of jammed packings of deformable particles in three dimensions Open
We investigate the structural, vibrational, and mechanical properties of jammed packings of deformable particles with shape degrees of freedom in three dimensions (3D). Each 3D deformable particle is modeled as a surface-triangulated polyh…
View article: Irreversibility in dynamical phases and transitions
Irreversibility in dynamical phases and transitions Open
Living and non-living active matter consumes energy at the microscopic scale to drive emergent, macroscopic behavior including traveling waves and coherent oscillations. Recent work has characterized non-equilibrium systems by their total …