Michael Phan
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500 Elucidating the epigenetic regulation of estrogen receptor-positive breast cancer cells by parathyroid hormone-related protein (PTHrP) Open
Objectives/Goals: We have shown that parathyroid hormone-related protein (PTHrP) is enriched at the LIFR promoter in breast cancer cells and inhibits the expression of dormancy-associated genes including LIFR. The objective of this study i…
Rapid Detection of PML::RARA Fusions in Acute Promyelocytic Leukemia: CRISPR/Cas9 Nanopore Sequencing with Adaptive Sampling Open
Acute promyelocytic leukemia (APL) accounts for approximately 10–15% of newly diagnosed acute myeloid leukemia cases and presents with coagulopathy and bleeding. Prompt diagnosis and treatment are required to minimize early mortality in AP…
An Integrated Approach Including CRISPR/Cas9-Mediated Nanopore Sequencing, Mate Pair Sequencing, and Cytogenomic Methods to Characterize Complex Structural Rearrangements in Acute Myeloid Leukemia Open
Complex structural chromosome abnormalities such as chromoanagenesis have been reported in acute myeloid leukemia (AML). They are usually not well characterized by conventional genetic methods, and the characterization of chromoanagenesis …
View article: One swab, two tests: Validation of dual SARS-CoV-2 testing on the Abbott ID NOW™
One swab, two tests: Validation of dual SARS-CoV-2 testing on the Abbott ID NOW™ Open
Storing spent dry swabs in transport media for redundancy rRT-PCR testing is a potential approach to address possible false negatives with the ID NOW™ COVID-19 assay.
PKCα-mediated phosphorylation of the diacylglycerol kinase ζ MARCKS domain switches cell migration modes by regulating interactions with Rac1 and RhoA Open
Cells can switch between Rac1 (lamellipodia-based) and RhoA (blebbing-based) migration modes, but the molecular mechanisms regulating this shift are not fully understood. Diacylglycerol kinase ζ (DGKζ), which phosphorylates diacylglycerol …
Ulcerative injection-site reaction associated with dupilumab therapy Open
Dupixent (dupilumab; Regeneron Pharmaceuticals, Inc.) is a fully human monoclonal antibody that inhibits interleukin 4 (IL-4) and IL-13 signaling by specifically binding to the IL-4R-alfa subunit shared by the IL-4 and IL-13 receptor compl…
Norman Orentreich: Father of Hair Modern Transplantation Open
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MARCKS domain phosphorylation regulates the differential interaction of Diacylglycerol Kinase ζ with Rac1, RhoA and Syntrophin Open
Cells can switch between Rac1, lamellipodia-based and RhoA, blebbing-based migration modes but the molecular mechanisms regulating this choice are not fully understood. Diacylglycerol kinase ζ (DGKζ), which phosphorylates diacylglycerol to…