Michael Punsoni
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View article: Case Report: Recurrent High-Risk Neuroblastoma in an Adult Woman 28 Years Following Curative Treatment
Case Report: Recurrent High-Risk Neuroblastoma in an Adult Woman 28 Years Following Curative Treatment Open
An adult woman with a remote history of childhood neuroblastoma at age two presented to the hospital with spinal cord compression. She was ultimately diagnosed with metastatic neuroblastoma 28 years following her initial diagnosis. The pat…
View article: Intradural extramedullary solitary plasmacytoma originating in the cervical spine in the setting of refractory multiple myeloma: illustrative case
Intradural extramedullary solitary plasmacytoma originating in the cervical spine in the setting of refractory multiple myeloma: illustrative case Open
BACKGROUND Multiple myeloma (MM) and plasmacytoma metastases to the spine are extremely rare, with 9 cases reported in the literature. Only 2 describe cases of solitary plasmacytoma (SP) specifically in the cervical spine, both in patients…
View article: Extra-axial small cell prostate carcinoma intracranial metastasis: illustrative case
Extra-axial small cell prostate carcinoma intracranial metastasis: illustrative case Open
BACKGROUND Prostate carcinoma, despite being the most common cancer in men, rarely metastasizes to the brain. Small cell prostate carcinoma represents a small percentage of cases, and few cases of intracranial small cell prostate metastase…
View article: IGV-001 cellular immunotherapy for newly diagnosed glioblastoma: overcoming the logistic challenge
IGV-001 cellular immunotherapy for newly diagnosed glioblastoma: overcoming the logistic challenge Open
Background IGV-001 is a type of cellular immunotherapy currently being investigated for treating glioblastoma (NCT04485949). It uses the patient’s tumor to elicit an autologous immune response. Methods The process involves (i) craniotomy f…
View article: Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug delivery and potentiates chemotherapy in GBM
Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug delivery and potentiates chemotherapy in GBM Open
Efficient drug delivery to glioblastoma (GBM) is a major obstacle as the blood-brain barrier (BBB) and the blood-tumor barrier (BTB) prevent passage of the majority of chemotherapies into the brain. Here, we identified a transcriptional 12…
View article: The Surgical Histopathology of the Filum Terminale: Findings from a Large Series of Patients with Tethered Cord Syndrome
The Surgical Histopathology of the Filum Terminale: Findings from a Large Series of Patients with Tethered Cord Syndrome Open
This study investigated the prevalence of embryonic and connective tissue elements in the filum terminale (FT) of patients with tethered cord syndrome (TCS), examining both typical and pathological histology. The FT specimens from 288 pati…
View article: The Surgical Histopathology of the Filum Terminale: Findings from a Large Series of Patients with Tethered Cord Sydrome
The Surgical Histopathology of the Filum Terminale: Findings from a Large Series of Patients with Tethered Cord Sydrome Open
This study investigated the prevalence of embryonic and connective tissue elements in the filum terminale (FT) of patients with tethered cord syndrome (TCS), examining both typical and pathological histology. FT specimens from 288 patients…
View article: Post-Polio Syndrome Revisited
Post-Polio Syndrome Revisited Open
Post-polio syndrome (PPS) is characterized by recrudescence or worsening of motor neuron disease symptoms decades after recovery from acute paralytic poliovirus infection, i.e., poliomyelitis. PPS afflicts between 25% and 40% of poliomyeli…
View article: Acute, nontraumatic subdural hemorrhage as a presentation of meningioma: A report of two cases and literature review
Acute, nontraumatic subdural hemorrhage as a presentation of meningioma: A report of two cases and literature review Open
Meningiomas are the most common primary intracranial neoplasms. Their presentation is variable with many found incidentally after cranial imaging is performed for an unrelated reason. Although seizure or neurologic deficits may occur, pres…
View article: Androgen Receptor, Although Not a Specific Marker For, Is a Novel Target to Suppress Glioma Stem Cells as a Therapeutic Strategy for Glioblastoma
Androgen Receptor, Although Not a Specific Marker For, Is a Novel Target to Suppress Glioma Stem Cells as a Therapeutic Strategy for Glioblastoma Open
Targeting androgen receptor (AR) has been shown to be promising in treating glioblastoma (GBM) in cell culture and flank implant models but the mechanisms remain unclear. AR antagonists including enzalutamide are available for treating pro…
View article: Clinical Reasoning: A 40-Year-Old Woman With Scapular Winging and Dysphonia
Clinical Reasoning: A 40-Year-Old Woman With Scapular Winging and Dysphonia Open
A 40-year-old woman presented to the neuromuscular clinic for evaluation of chronic right shoulder weakness of 1-year duration. During that time, she noticed progressive difficulties lifting her right arm overhead and reaching for objects …
View article: Pathologic Characteristics Associated With Local Recurrence of Atypical Meningiomas Following Surgical Resection
Pathologic Characteristics Associated With Local Recurrence of Atypical Meningiomas Following Surgical Resection Open
Currently considered histopathologic factors appear not to be helpful in guiding initial treatment course. History of prior local failure and bone invasion appear to be associated with multiple recurrences. Optimal surgical resection is cr…
View article: Teaching NeuroImages: Presentation of diffuse large B-cell lymphoma with bilateral sequential oculomotor neuropathy
Teaching NeuroImages: Presentation of diffuse large B-cell lymphoma with bilateral sequential oculomotor neuropathy Open
A 56-year-old man with HIV on combination antiretroviral therapy (CD4 count 368 cells/μL; HIV-RNA < 20 copies/mL) had sequential, bilateral oculomotor nerve palsy after recent travel to Africa. Nonexpansile enhancement of the oculomotor ne…
View article: Minimally invasive endoscopic spinal cord untethering: case report
Minimally invasive endoscopic spinal cord untethering: case report Open
Tethered cord syndrome is a constellation of symptoms and signs that include back and leg pain, bowel and bladder dysfunction, scoliosis and lower extremity weakness and deformity. Tethering may be due to a tight filum terminale or a form …
View article: The Masquerading Cyst: Extraparenchymal Neurocysticercosis Presenting as Acute Meningitis
The Masquerading Cyst: Extraparenchymal Neurocysticercosis Presenting as Acute Meningitis Open
View article: Surgical treatment results and pathological features in pediatric occult tight filum syndrome
Surgical treatment results and pathological features in pediatric occult tight filum syndrome Open
View article: De novo adamantinomatous craniopharyngioma presenting anew in an elderly patient with previous normal CT and MRI studies: A case report and implications on pathogenesis
De novo adamantinomatous craniopharyngioma presenting anew in an elderly patient with previous normal CT and MRI studies: A case report and implications on pathogenesis Open
Adamantinomatous craniopharyngiomas are histologically benign epithelial tumors which arise from embryonic remnants of the craniopharyngeal duct and Rathke’s pouch. They are thought to have a congenital origin and are histologically unique…
View article: Acute anoxic changes in peripheral nerve: anatomic and physiologic correlations
Acute anoxic changes in peripheral nerve: anatomic and physiologic correlations Open
Introduction The response of the peripheral nerve to anoxia is modulated by many factors including glucose and temperature. The purposes of this article are to demonstrate the effects of these factors on the pathological changes induced by…