Michael Q. Jiang
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View article: Plasma H3.1 nucleosomes as biomarkers of infection, inflammation and organ failure
Plasma H3.1 nucleosomes as biomarkers of infection, inflammation and organ failure Open
View article: Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer’s disease
Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer’s disease Open
Stroke and Alzheimer’s disease are common neurological disorders and often occur in the same individuals. The comorbidity of the two neurological disorders represents a grave health threat to older populations. This review presents a brief…
View article: Reprogramming Glioblastoma Cells into Non-Cancerous Neuronal Cells as a Novel Anti-Cancer Strategy
Reprogramming Glioblastoma Cells into Non-Cancerous Neuronal Cells as a Novel Anti-Cancer Strategy Open
Glioblastoma Multiforme (GBM) is an aggressive brain tumor with a high mortality rate. Direct reprogramming of glial cells to different cell lineages, such as induced neural stem cells (iNSCs) and induced neurons (iNeurons), provides genet…
View article: Strain hypothesis and additional evidence of the GluN3A deficiency‐mediated pathogenesis of Alzheimer's disease
Strain hypothesis and additional evidence of the GluN3A deficiency‐mediated pathogenesis of Alzheimer's disease Open
Our recent investigation revealed that deficiency of N‐methyl‐D‐aspartate (NMDA) receptor subunit GluN3A (NR3A) is a trigger for chronic neuronal hyperactivity and disruption of Ca 2+ homeostasis, leading to sporadic Alzheimer's disease (A…
View article: Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer’s disease
Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer’s disease Open
View article: Glycosaminoglycan scaffolding and neural progenitor cell transplantation promotes regenerative immunomodulation in the mouse ischemic brain
Glycosaminoglycan scaffolding and neural progenitor cell transplantation promotes regenerative immunomodulation in the mouse ischemic brain Open
View article: Conversion of Reactive Astrocytes to Induced Neurons Enhances Neuronal Repair and Functional Recovery After Ischemic Stroke
Conversion of Reactive Astrocytes to Induced Neurons Enhances Neuronal Repair and Functional Recovery After Ischemic Stroke Open
The master neuronal transcription factor NeuroD1 can directly reprogram astrocytes into induced neurons (iNeurons) after stroke. Using viral vectors to drive ectopic ND1 expression in gliotic astrocytes after brain injury presents an autol…
View article: Cortical Transplantation of Brain‐Mimetic Glycosaminoglycan Scaffolds and Neural Progenitor Cells Promotes Vascular Regeneration and Functional Recovery after Ischemic Stroke in Mice
Cortical Transplantation of Brain‐Mimetic Glycosaminoglycan Scaffolds and Neural Progenitor Cells Promotes Vascular Regeneration and Functional Recovery after Ischemic Stroke in Mice Open
Stroke causes significant mortality and morbidity. Currently, there are no treatments which can regenerate brain tissue lost to infarction. Neural progenitor cells (NPCs) are at the forefront of preclinical studies for regenerative stroke …
View article: Protective effects of GPR37 <i>via</i> regulation of inflammation and multiple cell death pathways after ischemic stroke in mice
Protective effects of GPR37 <i>via</i> regulation of inflammation and multiple cell death pathways after ischemic stroke in mice Open
GPCR 37 (GPR37) is a GPCR expressed in the CNS; its physiological and pathophysiological functions are largely unknown. We tested the role of GPR37 in the ischemic brain of GPR37 knockout (KO) mice, exploring the idea that GPR37 might be p…
View article: Temporal Gene Expression Profiles after Focal Cerebral Ischemia in Mice
Temporal Gene Expression Profiles after Focal Cerebral Ischemia in Mice Open
A cascade of pathological processes is triggered in the lesion area after ischemic stroke. Unfortunately, our understanding of these complicated molecular events is incomplete. In this investigation, we sought to better understand the deta…
View article: Bone Marrow Hematopoietic Stem Cell Therapy in Stroke
Bone Marrow Hematopoietic Stem Cell Therapy in Stroke Open
Mammalian bone marrow is host to an active stem cell population with the responsibility of maintaining and replenishing a variety of high turnover cells that are vital for survival, regeneration, and support of the rest of the body. The ma…
View article: Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice
Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice Open
View article: Long‐term survival and regeneration of neuronal and vasculature cells inside the core region after ischemic stroke in adult mice
Long‐term survival and regeneration of neuronal and vasculature cells inside the core region after ischemic stroke in adult mice Open
Focal cerebral ischemia results in an ischemic core surrounded by the peri‐infarct region (penumbra). Most research attention has been focused on penumbra while the pattern of cell fates inside the ischemic core is poorly defined. In the p…
View article: Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome
Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome Open
The PI3K enhancer PIKE links PI3K catalytic subunits to group 1 metabotropic glutamate receptors (mGlu1/5) and activates PI3K signaling. The roles of PIKE in synaptic plasticity and the etiology of mental disorders are unknown. Here, we sh…