Michael R. Doschak
YOU?
Author Swipe
View article: Modeling and optimization of cranial suture anisotropic material properties using a response surface methodology
Modeling and optimization of cranial suture anisotropic material properties using a response surface methodology Open
The present study aimed to develop and validate a transversely isotropic finite element (FE) model of the cranial suture that predicts suture mechanics, validated using ex-vivo data from the swine internasal suture. A 2D displacement-contr…
View article: Transplantation of vitrified osteochondral allografts revealed equivalent cartilage repair to fresh osteochondral allografts in a swine model
Transplantation of vitrified osteochondral allografts revealed equivalent cartilage repair to fresh osteochondral allografts in a swine model Open
Despite improvements in treatment options and techniques, articular cartilage (AC) repair continues to be a challenge for orthopedic surgeons. The use of osteochondral allografts for AC repair is currently limited by the availability and s…
View article: Improving Ex Vivo Nasal Mucosa Experimental Design for Drug Permeability Assessments: Correcting Mucosal Thickness Interference and Reevaluating Fluorescein Sodium as an Integrity Marker for Chemically Induced Mucosal Injury
Improving Ex Vivo Nasal Mucosa Experimental Design for Drug Permeability Assessments: Correcting Mucosal Thickness Interference and Reevaluating Fluorescein Sodium as an Integrity Marker for Chemically Induced Mucosal Injury Open
Objectives: Ex vivo nasal mucosa models provide physiologically relevant platforms for evaluating nasal drug permeability; however, their application is often limited by high experimental variability and the absence of standardized methodo…
View article: Mesenchymal retinoic acid signaling is required for normal diaphragm development in mice
Mesenchymal retinoic acid signaling is required for normal diaphragm development in mice Open
Congenital diaphragmatic hernia (CDH) is characterized by incomplete formation of the diaphragm, causing herniation of the abdominal organs and subsequent lung hypoplasia; however, the etiology of CDH is poorly understood. The Retinoid Hyp…
View article: Loading rate, geometry, and damage state influence vertical extraction biomechanics in an ex vivo swine dental model
Loading rate, geometry, and damage state influence vertical extraction biomechanics in an ex vivo swine dental model Open
Introduction Validated models describing the biomechanics of tooth extraction are scarce. This study seeks to perform experimental and numerical characterization of vertical tooth extraction biomechanics in swine incisors with imposed vert…
View article: Erratum to “Oral administration of egg white ovotransferrin prevent osteoporosis in ovariectomized rats” [Food Science and Human Wellness 13 (2024) 2562-2572]
Erratum to “Oral administration of egg white ovotransferrin prevent osteoporosis in ovariectomized rats” [Food Science and Human Wellness 13 (2024) 2562-2572] Open
View article: Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats
Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats Open
Ovotransferrin, an iron-binding glycoprotein, accounting for approximately 12% of egg white protein, is a member of transferrin fam ily. Our previous studies showed that ovotransferrin stimulates the proliferation and differentiation of os…
View article: Disruption of the c‐terminal serine protease domain of <i>Fam111a</i> does not alter calcium homeostasis in mice
Disruption of the c‐terminal serine protease domain of <i>Fam111a</i> does not alter calcium homeostasis in mice Open
FAM111A gene mutations cause Kenney–Caffey syndrome (KCS) and Osteocraniostenosis (OCS), conditions characterized by short stature, low serum ionized calcium (Ca 2+ ), low parathyroid hormone (PTH), and bony abnormalities. The molecular me…
View article: Three-dimensional morphometric analysis of cranial sutures – A novel approach to quantitative analysis
Three-dimensional morphometric analysis of cranial sutures – A novel approach to quantitative analysis Open
Although the bulk morphometric variability between age groups was found to be statistically insignificant, the 3D variability within individuals point to the importance of analyzing suture form using 3D metrics when studying suture develop…
View article: Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes in Cannabis sativa
Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes in Cannabis sativa Open
Cannabis sativa is a plant used for recreational and therapeutic purposes; however, many of the secondary metabolites in the plant have not been thoroughly investigated. Stilbenes are a class of compounds with demonstrated anti-inflammator…
View article: Strain Measurement within an Intact Swine Periodontal Ligament
Strain Measurement within an Intact Swine Periodontal Ligament Open
The periodontal ligament (PDL) provides support, proprioception, nutrition, and protection within the tooth–PDL–bone complex (TPBC). While understanding the mechanical behavior of the PDL is critical, current research has inferred PDL mech…
View article: A new hypothesis of eudromaeosaurian evolution: CT scans assist in testing and constructing morphological characters
A new hypothesis of eudromaeosaurian evolution: CT scans assist in testing and constructing morphological characters Open
Eudromaeosauria is a clade of derived dromaeosaurids that typifies the common perception of ‘raptor’ dinosaurs. The evolutionary history of this clade has been controversial due to conflicting views of taxonomic identity, and because, due …
View article: Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis
Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis Open
Significance Significant calcium absorption across renal and intestinal epithelia occurs via the paracellular pathway. However, the identity of the paracellular pore involved is unknown. Claudin-2 and claudin-12 contribute paracellular cal…
View article: Mechanically Induced Structural Adaptations Of Cranial Sutures
Mechanically Induced Structural Adaptations Of Cranial Sutures Open
Introduction: Premature occlusions of craniofacial sutures can lead to several medical conditions, including but not limited to craniosynostosis, midfacial hypoplasia, and transverse maxillary deficiency.If left untreated, these conditions…
View article: Taking a crack at the dome: histopathology of a pachycephalosaurid (Dinosauria: Ornithischia) frontoparietal dome
Taking a crack at the dome: histopathology of a pachycephalosaurid (Dinosauria: Ornithischia) frontoparietal dome Open
Recent studies have identified numerous pathologies in the cranial domes of pachycephalosaurid dinosaurs. These studies utilized CT images of domes to identify secondary woven bone and sclerosis associated with the pathologies. These featu…
View article: Traditional Chinese Medicine “Pill”, an Ancient Dosage Form with Surprising Modern Pharmaceutical Characteristics
Traditional Chinese Medicine “Pill”, an Ancient Dosage Form with Surprising Modern Pharmaceutical Characteristics Open
View article: Tooth attachment and pleurodont implantation in lizards: Histology, development, and evolution
Tooth attachment and pleurodont implantation in lizards: Histology, development, and evolution Open
Squamates present a unique challenge to the homology and evolution of tooth attachment tissues. Their stereotypically pleurodont teeth are fused in place by a single “bone of attachment”, with seemingly dubious homology to the three‐part t…
View article: Influence of Selected Product and Process Parameters on Microstructure, Rheological, and Textural Properties of 3D Printed Cookies
Influence of Selected Product and Process Parameters on Microstructure, Rheological, and Textural Properties of 3D Printed Cookies Open
One of the major advantages of 3D food printing is the customizability in terms of structure, design, and nutritional content. However, printability of the ingredients and the quality of the 3D printed food products are dependent on severa…
View article: The iliosacral joint in lizards: an osteological and histological analysis
The iliosacral joint in lizards: an osteological and histological analysis Open
The development of the iliosacral joint (ISJ) in tetrapods represented a crucial step in the evolution of terrestrial locomotion. This structure is responsible for transferring forces between the vertebral column and appendicular skeleton,…
View article: Cranial ontogeny of <i>Thamnophis radix</i> (Serpentes: Colubroidea) with a re-evaluation of current paradigms of snake skull evolution
Cranial ontogeny of <i>Thamnophis radix</i> (Serpentes: Colubroidea) with a re-evaluation of current paradigms of snake skull evolution Open
Accurate knowledge of skeletal ontogeny in extant organisms is crucial in understanding important morpho-functional systems and in enabling inferences of the ontogenetic stage of fossil specimens. However, detailed knowledge of skeletal on…
View article: Increased FoxO3a expression prevents osteoblast differentiation and matrix calcification
Increased FoxO3a expression prevents osteoblast differentiation and matrix calcification Open
Forkhead Box O transcription factors play important roles in bone metabolism by defending against oxidative stress and apoptosis. FoxO3a is of special interest as it is the predominant isoform expressed in bone. In osteoblasts, the adminis…
View article: DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways
DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways Open
Doxorubicin (DOX) is a very potent and effective anticancer agent. However, the effectiveness of DOX in osteosarcoma is usually limited by the acquired drug resistance. Recently, Vitamin D (Vit-D) was shown to suppress the growth of many h…
View article: Editorial
Editorial Open
View article: Reacquisition of the lower temporal bar in sexually dimorphic fossil lizards provides a rare case of convergent evolution
Reacquisition of the lower temporal bar in sexually dimorphic fossil lizards provides a rare case of convergent evolution Open
View article: Effect of ultrasound on human umbilical cord peri-vascular cells
Effect of ultrasound on human umbilical cord peri-vascular cells Open
Background: Tissue engineering involves using different types of stem cells. One of the roadblocks in tissue engineering is the scant supply of stem cells. The potential use of human umbilical cord peri-vascular Cells (HUCPVCs) has recentl…
View article: Using Micro-CT Derived Bone Microarchitecture to Analyze Bone Stiffness – A Case Study on Osteoporosis Rat Bone
Using Micro-CT Derived Bone Microarchitecture to Analyze Bone Stiffness – A Case Study on Osteoporosis Rat Bone Open
Micro-computed tomography (Micro-CT) images can be used to quantitatively represent bone geometry through a range of computed attenuation-based parameters. Nonetheless, those parameters remain indirect indices of bone microarchitectural st…
View article: 3‐D localization of non‐radioactive strontium in osteoarthritic bone: Role in the dynamic labeling of bone pathological changes
3‐D localization of non‐radioactive strontium in osteoarthritic bone: Role in the dynamic labeling of bone pathological changes Open
The study objective was to visualize regions of bone that undergo pathological mineralization and/or remodeling during pathogenesis of osteoarthritis, by employing non‐radioactive strontium as a dynamic tracer of bone turnover. Post trauma…
View article: Effect of low‐level laser therapy on dental root cementum remodeling in rats
Effect of low‐level laser therapy on dental root cementum remodeling in rats Open
Structured Abstract Objective To investigate the amount of the cementum layer formed over the rat's dental root surfaces by daily application of low‐level laser therapy (LLLT) for 2 weeks. Methods Twelve female Sprague‐Dawley (SD) rats wer…