Michael R. Hicks
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View article: Transcytotic transportation of size-controlled nanocarriers into dystrophic skeletal muscle leads to therapeutic outcome in mice
Transcytotic transportation of size-controlled nanocarriers into dystrophic skeletal muscle leads to therapeutic outcome in mice Open
Duchenne Muscular Dystrophy (DMD) is a lethal muscle-wasting disorder with limited therapeutic options. Although nano drug delivery offers promise, the biodistribution and access routes to dystrophic muscle remain poorly understood. Here w…
View article: Creating Skeletal Muscle from Stem Cells
Creating Skeletal Muscle from Stem Cells Open
View article: Publisher Correction: Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells
Publisher Correction: Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells Open
View article: Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells
Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells Open
View article: Nanoparticles systemically biodistribute to regenerating skeletal muscle in DMD
Nanoparticles systemically biodistribute to regenerating skeletal muscle in DMD Open
View article: SIX1+PAX3+ identify a progenitor for myogenic lineage commitment from hPSCs
SIX1+PAX3+ identify a progenitor for myogenic lineage commitment from hPSCs Open
The earliest skeletal muscle progenitor cells (SMPCs) derived from human pluripotent stem cells (hPSCs) are often identified by factors expressed by a diverse number of progenitors. An early transcriptional checkpoint that defines myogenic…
View article: Duchenne muscular dystrophy disease severity impacts skeletal muscle progenitor cells systemic delivery
Duchenne muscular dystrophy disease severity impacts skeletal muscle progenitor cells systemic delivery Open
Duchenne muscular dystrophy (DMD) is caused by an out-of-frame mutation in the DMD gene that results in the absence of a functional dystrophin protein, leading to a devastating progressive lethal muscle-wasting disease. Muscle stem cell-ba…
View article: Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis
Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis Open
We developed an on-slide decellularization approach to generate acellular extracellular matrix (ECM) myoscaffolds that can be repopulated with various cell types to interrogate cell-ECM interactions. Using this platform, we investigated wh…
View article: Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models
Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models Open
Duchenne muscular dystrophy (DMD) is caused by out-of-frame mutations in the DMD gene resulting in the absence of a functional dystrophin protein, leading to a devastating and progressive lethal muscle-wasting disease. Little is known abou…
View article: The emergence of the stem cell niche
The emergence of the stem cell niche Open
View article: Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis
Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis Open
We developed an on-slide decellularization approach to generate acellular extracellular matrix (ECM) scaffolds that can be repopulated with various cell types to interrogate cell-ECM interactions. Using this platform, we investigated wheth…
View article: A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells
A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells Open
View article: A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells
A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells Open
View article: A customizable microfluidic platform for medium-throughput modeling of neuromuscular circuits
A customizable microfluidic platform for medium-throughput modeling of neuromuscular circuits Open
View article: ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs
ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs Open
View article: 735. Functional Restoration of Dystrophin Protein in HiPSC-Derived Skeletal Myotubes and Cardiomyocytes After CRISPR/Cas9-Mediated Deletion of 530-725kb of DMD
735. Functional Restoration of Dystrophin Protein in HiPSC-Derived Skeletal Myotubes and Cardiomyocytes After CRISPR/Cas9-Mediated Deletion of 530-725kb of DMD Open
Duchenne muscular dystrophy (DMD) is typically due to frameshifting mutations in the DMD gene encoding dystrophin. Loss of dystrophin protein results in progressive muscle degeneration and premature death. Approximately 60% of DMD patients…
View article: A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells
A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells Open
View article: The Path from Pluripotency to Skeletal Muscle: Developmental Myogenesis Guides the Way
The Path from Pluripotency to Skeletal Muscle: Developmental Myogenesis Guides the Way Open