David J. Gawkrodger
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View article: CD05 The hazards of patch testing in a patient with Hailey–Hailey disease
CD05 The hazards of patch testing in a patient with Hailey–Hailey disease Open
The tendency to intraepidermal acantholysis seen in Hailey–Hailey disease, due to weakened desmosomal adhesions, can present problems when patch testing a patient with the disease. A 51-year-old man with Hailey–Hailey disease affecting the…
View article: CD07 Cananga oil and ylang ylang oil: different haptens but with the same INCI name. The importance of patch testing to both
CD07 Cananga oil and ylang ylang oil: different haptens but with the same INCI name. The importance of patch testing to both Open
Cananga oil and ylang ylang oil are essentials oils used in perfumed products such as cosmetics, soaps and perfumery. The haptens ‘cananga oil, C-002’ and ‘ylang ylang oil (Cananga odorata), Y-001’ are available from Chemotechnique for pat…
View article: BG03 Biologics for psoriasis in the older patient: profiles, pitfalls and practicalities
BG03 Biologics for psoriasis in the older patient: profiles, pitfalls and practicalities Open
Psoriasis occurs at any age but its appearance in the seventh or subsequent decades may at first seem to present additional challenges. Around 15% of older patients with psoriasis have moderate-to-severe involvement that requires systemic …
View article: Sodium Benzoate as an Emerging but Problematic Allergen: Retrospective Analysis of Patch Test Results in 3198 Cases Underlines the Need for an Improved Test Preparation, as Even Dubious Reactions May Be Clinically Relevant
Sodium Benzoate as an Emerging but Problematic Allergen: Retrospective Analysis of Patch Test Results in 3198 Cases Underlines the Need for an Improved Test Preparation, as Even Dubious Reactions May Be Clinically Relevant Open
Background Sodium benzoate is increasingly used as a preservative in personal care products and in foods. Recently published experience of patch testing sodium benzoate at 5% in pet shows it to be an allergen that may be assuming increasin…
View article: H02 Superficial X-rays and grenz rays for benign dermatoses: from saviour to pariah over the course of the 20th century – the story of the remarkable rise and slow decline of an entire therapeutic modality and its potential for revival
H02 Superficial X-rays and grenz rays for benign dermatoses: from saviour to pariah over the course of the 20th century – the story of the remarkable rise and slow decline of an entire therapeutic modality and its potential for revival Open
Dermatologists in the decade spanning the turn of the 19th century thought they were on to something with the discovery of X-rays by Wilhelm Röntgen at Würzburg in 1895. Effects on the skin were soon apparent from the earliest experiments,…
View article: Vitiligo and psychological stress: A hypothesis integrating the neuroendocrine and immune systems in melanocyte destruction
Vitiligo and psychological stress: A hypothesis integrating the neuroendocrine and immune systems in melanocyte destruction Open
Vitiligo is an acquired disease, characterized microscopically by the destruction of neural-crest-derived melanocytes, that may be precipitated by local skin trauma, mental stress, and chemical imbalances, all of which suggest neuroendocri…
View article: Trends in work-related respiratory diseases attributed to nickel, chromium and cobalt in the UK: descriptive findings from The Health and Occupation Research (THOR) network 1996–2019
Trends in work-related respiratory diseases attributed to nickel, chromium and cobalt in the UK: descriptive findings from The Health and Occupation Research (THOR) network 1996–2019 Open
Background Occupational exposure to metals can be associated with respiratory diseases which can adversely affect the individual’s health, finances and employment. Despite this, little is known about the incidence of these respiratory cond…
View article: The contribution of metal allergy to the failure of metal alloy implants, with special reference to titanium: Current knowledge and controversies
The contribution of metal allergy to the failure of metal alloy implants, with special reference to titanium: Current knowledge and controversies Open
After almost three‐quarters of a century during which contact dermatologists have often struggled to comprehend the relationship between metal allergy and failure of metal‐alloy containing implant, it is possible to say that a relationship…
View article: Trends in occupational and work-related contact dermatitis attributed to nickel, chromium and cobalt in the UK: findings from The Health and Occupation Research network 1996–2019
Trends in occupational and work-related contact dermatitis attributed to nickel, chromium and cobalt in the UK: findings from The Health and Occupation Research network 1996–2019 Open
Background Occupational exposure to metals such as nickel, chromium and cobalt can be associated with contact dermatitis, which can adversely affect an individual’s health, finances and employment. Despite this, little is known about the i…
View article: H01 Chloracne: historical perspectives on an occupational disease, often the result of notorious environmental poisoning
H01 Chloracne: historical perspectives on an occupational disease, often the result of notorious environmental poisoning Open
First described by the Heidelberg dermatologist Siegfried Bettman in 1897 as an occupational disease in chemical workers cleaning out towers filled with hydrochloric acid, chloracne—not a true acne, despite showing comedones, cysts and pus…
View article: Skin and respiratory ill-health attributed to occupational face mask use
Skin and respiratory ill-health attributed to occupational face mask use Open
Background Face mask use in the workplace has become widespread since the onset of the Covid-19 pandemic and has been anecdotally linked to adverse health consequences. Aims To examine reports of adverse health consequences of occupational…
View article: Patho-immunological mechanisms of vitiligo: the role of the innate and adaptive immunities and environmental stress factors
Patho-immunological mechanisms of vitiligo: the role of the innate and adaptive immunities and environmental stress factors Open
Epidermal melanocyte loss in vitiligo, triggered by stresses ranging from trauma to emotional stress, chemical exposure or metabolite imbalance, to the unknown, can stimulate oxidative stress in pigment cells, which secrete damage-associat…
View article: Patho-immunological mechanisms of vitiligo: an integration of the immunogenetic milieu, with innate and adaptive immunities, as triggered by environmental stress factors
Patho-immunological mechanisms of vitiligo: an integration of the immunogenetic milieu, with innate and adaptive immunities, as triggered by environmental stress factors Open
Epidermal melanocyte loss in vitiligo, triggered by stresses ranging from trauma to emo-tional stress, chemical exposure or metabolite imbalance, to the unknown, can stimulate oxidative stress in pigment cells which secrete damage-associat…