Explanipedia

Goal-directedness deficit in Huntington’s disease Open

Lee‐Anne Morris, Sanjay Manohar, Kyla‐Louise Horne, Laura Paermentier, Christina M. Buchanan , et al. · 2025

Apathy and impulsive behaviour co-occur in Huntington’s disease (HD), but these debilitating behavioural syndromes are multidimensional constructs, raising the question of which specific dimensions drive this relationship and the stability…

Disrupted Time Perception Underlies Motivational Disturbances in Huntington’s Disease Open

Lee‐Anne Morris, Kyla‐Louise Horne, Sanjay Manohar, Laura Paermentier, Christina M. Buchanan , et al. · 2024

Our sense of time is fundamental to interacting with the world in a goal-directed manner, with decisions underpinning goal pursuit utilising timing circuits in the seconds-to-minutes range. A reduction in goal-directed behaviour — apathy —…

Apathy and Impulsivity Co‐Occur in Huntington's Disease Open

Lee‐Anne Morris, Kyla‐Louise Horne, Laura Paermentier, Christina M. Buchanan, Michael R. MacAskill , et al. · 2024

Background Apathy is a debilitating behavioral change in Huntington's disease (HD), but impulsivity in HD has not been well documented, and the co‐occurrence of these behaviors in HD has not been investigated. Objective Our objective was t…

Decision cost hypersensitivity underlies Huntington’s disease apathy Open

Lee‐Anne Morris, Kyla‐Louise Horne, Sanjay Manohar, Laura Paermentier, Christina M. Buchanan , et al. · 2024

The neuropsychiatric syndrome of apathy is now recognized to be a common and disabling condition in Huntington’s disease. However, the mechanisms underlying it are poorly understood. One way to investigate apathy is to use a theoretical fr…

Dimensions of apathy in Parkinson's disease Open

Nasya Thompson, Michael R. MacAskill, Maddie Pascoe, Tim Anderson, Campbell Le Heron · 2023

Introduction Apathy is one of the most common neuropsychiatric manifestations in Parkinson's disease (PD). Recent proposals consider apathy as a multidimensional construct, which can manifest in behavioral, cognitive, emotional, and/or soc…

Acquired Stuttering in Parkinson's Disease Open

Eloïse A. Gooch, Kyla‐Louise Horne, Tracy R. Melzer, Megan J. McAuliffe, Michael R. MacAskill , et al. · 2023

Background Parkinson's disease frequently causes communication impairments, but knowledge about the occurrence of new‐onset stuttering is limited. Objectives To determine the presence of acquired neurogenic stuttering and its relationship …

Altered nucleus accumbens functional connectivity precedes apathy in Parkinson’s disease Open

Lee‐Anne Morris, Samuel J. Harrison, Tracy R. Melzer, John C. Dalrymple‐Alford, Tim Anderson , et al. · 2023

Work in animal and human neuroscience has identified neural regions forming a network involved in the production of motivated, goal-directed behaviour. In particular, the nucleus accumbens and anterior cingulate cortex are recognized as ke…

The New Zealand Parkinson’s progression programme Open

Michael R. MacAskill, Toni L. Pitcher, Tracy R. Melzer, Daniel J. Myall, Kyla‐Louise Horne , et al. · 2022

We describe the New Zealand Parkinson's Progression Programme (NZP3), its goals, findings, and future plans. To date, 354 people with Parkinson's disease and 89 healthy older controls have participated over a 14-year period. A major focus …

Non-Contact Hand Movement Analysis for Optimal Configuration of Smart Sensors to Capture Parkinson’s Disease Hand Tremor Open

Prashanna Khwaounjoo, Gurleen Singh, Sophie Grenfell, Burak Özsoy, Michael R. MacAskill , et al. · 2022

Parkinson’s disease affects millions worldwide with a large rise in expected burden over the coming decades. More easily accessible tools and techniques to diagnose and monitor Parkinson’s disease can improve the quality of life of patient…

A Multi‐Step Model of Parkinson's Disease Pathogenesis Open

Campbell Le Heron, Michael R. MacAskill, Deborah Mason, John C. Dalrymple‐Alford, Tim Anderson , et al. · 2021

Background Parkinson's disease (PD) may result from the combined effect of multiple etiological factors. The relationship between disease incidence and age, as demonstrated in the cancer literature, can be used to model a multistep pathoge…

Neuropsychiatric Symptoms Are Associated with Dementia in Parkinson's Disease but Not Predictive of it Open

Kyla‐Louise Horne, Michael R. MacAskill, Daniel J. Myall, Leslie Livingston, Sophie Grenfell , et al. · 2021

Background Neuropsychiatric symptoms in Parkinson's disease (PD) may increase dementia (PDD) risk. The predictive value of these symptoms, however, has not been compared to clinical and demographic predictors of future PDD. Objectives Dete…

Positive Association of Ascorbate and Inverse Association of Urate with Cognitive Function in People with Parkinson’s Disease Open

Emma Spencer, Toni L. Pitcher, Gabriel Verón, Tracey Hannam, Michael R. MacAskill , et al. · 2020

Oxidative stress is thought to contribute to the aetiology of neurological disorders such as Parkinson’s disease. Ascorbate (vitamin C) is a potent antioxidant and is associated with neurological and cognitive function. In this study we as…

Neuropsychiatric symptoms are associated with dementia in Parkinson’s disease but not predictive of it Open

Kyla‐Louise Horne, Michael R. MacAskill, Daniel J. Myall, Leslie Livingston, Sophie Grenfell , et al. · 2020

Background Neuropsychiatric symptoms in Parkinson’s disease (PD) may increase dementia (PDD) risk. The predictive value of these symptoms, however, has not been compared to clinical and demographic predictors of future PDD. Methods 325 PD …

The timing mega-study: comparing a range of experiment generators, both lab-based and online Open

David Bridges, Alain Pitiot, Michael R. MacAskill, Jonathan W. Peirce · 2020

Many researchers in the behavioral sciences depend on research software that presents stimuli, and records response times, with sub-millisecond precision. There are a large number of software packages with which to conduct these behavioral…

Cognitive tests that identify high risk of conversion to dementia in Parkinson’s disease Open

Daniel J. Myall, Kyla‐Louise Horne, Michael R. MacAskill, Leslie Livingston, Toni L. Pitcher , et al. · 2020

Background People with Parkinson’s disease who meet criteria for mild cognitive impairment are at increased risk of dementia. It is not known which tests are more effective than others for identifying the risk of dementia. Methods At basel…

Microstructural integrity of the major nuclei of the thalamus in Parkinson’s disease Open

Nadia Borlase, Daniel J. Myall, Tracy R. Melzer, Leslie Livingston, Richard Watts , et al. · 2020

Background Previous research has shown an association between thalamus and cognition in Parkinson’s disease (PD). Objectives To investigate the microstructural integrity of the nuclei of the thalamus and relationship with cognition. Method…

“Pervasive ocular tremor of Parkinson’s” is not pervasive, ocular, or uniquely parkinsonian Open

Michael R. MacAskill, Daniel J. Myall · 2020

A putative tremulous oscillation of the eyes has been proposed to provide the long-sought objective, sensitive and specific diagnostic sign for Parkinson’s disease . Vigorous debate has ensued as to whether this “ocular tremor” is a real p…

The timing mega-study: comparing a range of experiment generators, both lab-based and online Open

David Bridges, Alain Pitiot, Michael R. MacAskill, Jonathan W. Peirce · 2020

Many researchers in the behavioral sciences depend on research software that presents stimuli, and records response times, with sub-millisecond precision. There are a large number of software packages with which to conduct these behavioura…

Changes of plasma cGP/IGF‐1 molar ratio with age is associated with cognitive status of Parkinson disease Open

Dawei Fan, Toni L. Pitcher, John C. Dalrymple‐Alford, Michael R. MacAskill, Tim Anderson , et al. · 2020

Old healthy people with a higher cGP/IGF-1 molar ratio showed better preserved cognition, possibly due to improved IGF-1 function. Increased cGP/IGF-1 molar ratio with age may contribute to cognitive retention in the PD-N group. The absenc…

Volitional Suppression of Parkinsonian Resting Tremor Open

Rebekah L. Blakemore, Michael R. MacAskill, Daniel J. Myall, Tim Anderson · 2019

Background We have observed in the clinic that a number of patients with Parkinson's disease (PD) can suppress their tremor at will for brief periods, by conscious mental processes. To our knowledge, the ability to consciously diminish one…

Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease Open

Tracy R. Melzer, Megan Stark, Ross Keenan, Daniel J. Myall, Michael R. MacAskill , et al. · 2019

The extent to which Alzheimer neuropathology, particularly the accumulation of misfolded beta-amyloid, contributes to cognitive decline and dementia in Parkinson's disease (PD) is unresolved. Here, we used Florbetaben PET imaging to test f…

Sensorimotor integration assessment by the Symbol-Digit modalities test in patients with Parkinson’s disease Open

Yassar Alamri, Maddie Pascoe, Michael R. MacAskill, Tim Anderson, John C. Dalrymple‐Alford · 2019

To the Editor We read the recent findings by Fil-Balkan et al,[1][1] with great interest. Multiple neuropsychological assessment tools have been utilised in patients with Parkinson’s disease to evaluate sensorimotor integration at various …

PsychoPy2: Experiments in behavior made easy Open

Jonathan W. Peirce, Jeremy Gray, Sol Simpson, Michael R. MacAskill, Richard Höchenberger , et al. · 2019

Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function Open

Dawei Fan, Yassar Alamri, Karen Liu, Michael R. MacAskill, Paul W. R. Harris , et al. · 2018

Background: Insulin-like growth factor-1 (IGF-1) function is impaired in Parkinson disease. Cyclic glycine-proline (cGP), a metabolite of IGF-1, is neuroprotective through improving IGF-1 function. Parkinson disease patients score lower on…

Response to “Parkinson's disease mild cognitive impairment classifications and neurobehavioral symptoms” Open

Kyla‐Louise Horne, Daniel J. Myall, Michael R. MacAskill, Tim Anderson, John C. Dalrymple‐Alford · 2018

A recent paper, "Parkinson's disease mild cognitive impairment classifications and neurobehavioral symptoms" (McDermott et al., 2017), provides an interesting comparison of the influence of different criteria for Parkinson's disease with m…

Caregiver burden is increased in Parkinson’s disease with mild cognitive impairment (PD-MCI) Open

Ann Judith Jones, Roeline G. Kuijer, Leslie Livingston, Daniel J. Myall, Kyla‐Louise Horne , et al. · 2017

Errors on the MoCA's animal-naming: findings from Parkinson's disease patients Open

Yassar Alamri, Tim Anderson, John C. Dalrymple‐Alford, Michael R. MacAskill · 2017

We read the findings by Cecato et al. (2016) with great interest. In their study, naming the rhinoceros discriminated between patients with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) but not healthy controls (HC…

Commentary: Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies Open

Yassar Alamri, Michael R. MacAskill, Tim Anderson · 2017

GENERAL COMMENTARY article Front. Aging Neurosci., 09 January 2017Sec. Parkinson’s Disease and Aging-related Movement Disorders Volume 8 - 2016 | https://doi.org/10.3389/fnagi.2016.00331

Different PD-MCI criteria and risk of dementia in Parkinson’s disease: 4-year longitudinal study Open

Kyla-Louise Wood, Daniel J. Myall, Leslie Livingston, Tracy R. Melzer, Toni L. Pitcher , et al. · 2016

Repeated Lumbar Punctures for Non-Clinical Indications: How Do Patients Feel? Open

Yassar Alamri, Michael R. MacAskill, Tim Anderson · 2016

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