Michael R. McAllaster
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View article: Shared host genetic landscape of respiratory viral infection
Shared host genetic landscape of respiratory viral infection Open
Respiratory viruses represent a major global health burden. Although these viruses have different life cycles, they may depend on common host genetic factors, which could be targeted by broad-spectrum host-directed therapies. We used genom…
View article: Autophagy gene-dependent intracellular immunity triggered by interferon-γ
Autophagy gene-dependent intracellular immunity triggered by interferon-γ Open
Genes required for the lysosomal degradation pathway of autophagy play key roles in topologically distinct and physiologically important cellular processes. Some functions of ATG genes are independent of their role in degradative autophagy…
View article: Investigation of IFNγ-induced Control of Intracellular Pathogens
Investigation of IFNγ-induced Control of Intracellular Pathogens Open
View article: Autophagy gene-dependent intracellular immunity triggered by interferon-γ
Autophagy gene-dependent intracellular immunity triggered by interferon-γ Open
Genes required for the lysosomal degradation pathway of autophagy play key roles in topologically distinct cellular processes with significant physiologic importance. One of the first-described of these ATG gene-dependent processes is the …
View article: A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis
A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis Open
Type 1 pili have long been considered the major virulence factor enabling colonization of the urinary bladder by uropathogenic Escherichia coli (UPEC). The molecular pathogenesis of pyelonephritis is less well characterized, due to previou…
View article: UFMylation inhibits the proinflammatory capacity of interferon-γ–activated macrophages
UFMylation inhibits the proinflammatory capacity of interferon-γ–activated macrophages Open
Significance Interferon-γ (IFN-γ)–dependent macrophage activation is an important component of the innate immune response. Although critical for cellular defenses against intracellular pathogens and activation of the adaptive immune system…
View article: Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity Open
View article: ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells
ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells Open
Interferon(s) provide the primary defense against intracellular pathogens, a property ascribed to their ability to upregulate interferon-stimulated genes. Due to the sequestered niche occupied by Toxoplasma gondii , the host has elaborated…
View article: Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation
Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation Open
Knowledge of the host factors required for norovirus replication has been hindered by the challenges associated with culturing human noroviruses. We have combined proteomic analysis of the viral translation and replication complexes with a…
View article: Author response: Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation
Author response: Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Knowledge of the host factors…
View article: Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock
Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock Open
Significance Sepsis is a multifactorial syndrome with increasing incidence and significant mortality. While previous work implicated tumor necrosis factor (TNF)-induced cell death in sepsis, a role for interferon-gamma (IFNγ), which synerg…
View article: Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis
Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis Open
Viruses hijack host machinery and regulate cellular homeostasis to actively replicate their genome, propagate, and cause disease. In retaliation, cells possess various defense mechanisms to detect, destroy, and clear infecting viruses, as …
View article: Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation
Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation Open
Knowledge of the host factors required for norovirus replication has been hindered by the challenges associated with culturing human noroviruses. We have combined proteomic analysis of the viral translation and replication complexes with a…
View article: Mouse Norovirus infection arrests host cell translation uncoupled from the stress granule-PKR-eIF2α axis
Mouse Norovirus infection arrests host cell translation uncoupled from the stress granule-PKR-eIF2α axis Open
The integrated stress response (ISR) is a cellular response system activated upon different types of stresses, including viral infection, to restore cellular homeostasis. However, many viruses manipulate this response for their own advanta…
View article: Tropism for tuft cells determines immune promotion of norovirus pathogenesis
Tropism for tuft cells determines immune promotion of norovirus pathogenesis Open
Aiding and abetting norovirus disease Norovirus is highly infectious and usually causes transient, acute disease. In some individuals, norovirus persists and is associated with inflammatory bowel disorders. While investigating the cell tro…
View article: TbSmee1 regulates hook complex morphology and the rate of flagellar pocket uptake in <i>Trypanosoma brucei</i>
TbSmee1 regulates hook complex morphology and the rate of flagellar pocket uptake in <i>Trypanosoma brucei</i> Open
Summary Trypanosoma brucei uses multiple mechanisms to evade detection by its insect and mammalian hosts. The flagellar pocket (FP) is the exclusive site of uptake from the environment in trypanosomes and shields receptors from exposure to…
View article: A functional analysis of TOEFAZ1 uncovers protein domains essential for cytokinesis in <i>Trypanosoma brucei</i>
A functional analysis of TOEFAZ1 uncovers protein domains essential for cytokinesis in <i>Trypanosoma brucei</i> Open
The parasite Trypanosoma brucei is highly polarized, including a flagellum that is attached along the cell surface by the flagellum attachment zone (FAZ). During cell division, the new FAZ positions the cleavage furrow, which ingresses fro…
View article: A unified approach towards Trypanosoma brucei functional genomics using Gibson assembly
A unified approach towards Trypanosoma brucei functional genomics using Gibson assembly Open
View article: Proteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in<i>Trypanosoma brucei</i>
Proteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in<i>Trypanosoma brucei</i> Open
Trypanosoma brucei is the causative agent of African sleeping sickness, a devastating disease endemic to sub-Saharan Africa with few effective treatment options. The parasite is highly polarized, including a single flagellum that is nuclea…