Michael R. Mulvey
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View article: Molecular epidemiology and in silico prediction of ciprofloxacin resistance in <i>Salmonella enterica</i> in Canada, 2017–2022
Molecular epidemiology and in silico prediction of ciprofloxacin resistance in <i>Salmonella enterica</i> in Canada, 2017–2022 Open
Ciprofloxacin is important for treatment of severe or invasive Salmonella infections in humans. As laboratories transition from phenotypic to genomics-based methods for determining ciprofloxacin non-susceptibility, it is important to defin…
View article: Correction: Using whole-genome sequence data to examine the epidemiology of Salmonella, Escherichia coli and associated antimicrobial resistance in raccoons (Procyon lotor), swine manure pits, and soil samples on swine farms in southern Ontario, Canada
Correction: Using whole-genome sequence data to examine the epidemiology of Salmonella, Escherichia coli and associated antimicrobial resistance in raccoons (Procyon lotor), swine manure pits, and soil samples on swine farms in southern Ontario, Canada Open
[This corrects the article DOI: 10.1371/journal.pone.0260234.].
View article: Global transmission of extended-spectrum cephalosporin resistance in Escherichia coli driven by epidemic plasmids
Global transmission of extended-spectrum cephalosporin resistance in Escherichia coli driven by epidemic plasmids Open
View article: When the Trojan horse is unable to reach inside the city: investigation of the mechanism of resistance behind the first reported cefiderocol-resistant <i>E. coli</i> in Canada
When the Trojan horse is unable to reach inside the city: investigation of the mechanism of resistance behind the first reported cefiderocol-resistant <i>E. coli</i> in Canada Open
Gram-negative metallo-β-lactamase-producing bacteria can be extremely problematic, especially when found to be extensively drug-resistant (XDR). Cefiderocol is a novel antimicrobial that has been shown to overcome most carbapenemases, with…
View article: Do we still need Illumina sequencing data? Evaluating Oxford Nanopore Technologies R10.4.1 flow cells and the Rapid v14 library prep kit for Gram negative bacteria whole genome assemblies
Do we still need Illumina sequencing data? Evaluating Oxford Nanopore Technologies R10.4.1 flow cells and the Rapid v14 library prep kit for Gram negative bacteria whole genome assemblies Open
The best whole genome assemblies are currently built from a combination of highly accurate short-read sequencing data and long-read sequencing data that can bridge repetitive and problematic regions. Oxford Nanopore Technologies (ONT) prod…
View article: Detection of Mpox Virus in Wastewater Provides Fore-Warning of Clinical Cases in Canadian Cities
Detection of Mpox Virus in Wastewater Provides Fore-Warning of Clinical Cases in Canadian Cities Open
View article: Plasmid genomic epidemiology of <i>bla</i> <sub>KPC</sub> carbapenemase-producing <i>Enterobacterales</i> in Canada, 2010–2021
Plasmid genomic epidemiology of <i>bla</i> <sub>KPC</sub> carbapenemase-producing <i>Enterobacterales</i> in Canada, 2010–2021 Open
Carbapenems are considered last-resort antibiotics for the treatment of infections caused by multidrug-resistant Enterobacterales , but carbapenem resistance due to acquisition of carbapenemase genes is a growing threat that has been repor…
View article: Antimicrobial susceptibilities of Neisseria gonorrhoeae in Canada, 2021
Antimicrobial susceptibilities of Neisseria gonorrhoeae in Canada, 2021 Open
The spread of antimicrobial-resistant gonorrhea is a significant public health concern. The continued regional and national surveillance of antimicrobial resistance in N. gonorrhoeae is essential in ensuring effective treatment ther…
View article: Do we still need Illumina sequencing data?: Evaluating Oxford Nanopore Technologies R10.4.1 flow cells and v14 library prep kits for Gram negative bacteria whole genome assemblies
Do we still need Illumina sequencing data?: Evaluating Oxford Nanopore Technologies R10.4.1 flow cells and v14 library prep kits for Gram negative bacteria whole genome assemblies Open
The best whole genome assemblies are currently built from a combination of highly accurate short-read sequencing data and long-read sequencing data that can bridge repetitive and problematic regions. Oxford Nanopore Technologies (ONT) prod…
View article: Sensibilité de Neisseria gonorrhoeae aux antimicrobiens au Canada, 2021
Sensibilité de Neisseria gonorrhoeae aux antimicrobiens au Canada, 2021 Open
Contexte : Au Canada, la gonorrhée est la deuxième infection bactérienne sexuellement transmissible la plus répandue.Le Programme de surveillance de la résistance des gonocoques aux antimicrobiens (GASP -Canada), un système de surveillance…
View article: Extended Spectrum β-Lactamase-Producing Enterobacterales of Shrimp and Salmon Available for Purchase by Consumers in Canada—A Risk Profile Using the Codex Framework
Extended Spectrum β-Lactamase-Producing Enterobacterales of Shrimp and Salmon Available for Purchase by Consumers in Canada—A Risk Profile Using the Codex Framework Open
The extended-spectrum β-lactamase (ESBL)-producing Enterobacterales (ESBL-EB) encompass several important human pathogens and are found on the World Health Organization (WHO) priority pathogens list of antibiotic-resistant bacteria. They a…
View article: Science to support conservation action in a large river system: The Willamette River, Oregon, USA
Science to support conservation action in a large river system: The Willamette River, Oregon, USA Open
Management and conservation efforts that support the recovery and protection of large rivers are daunting, reflecting the complexity of the challenge and extent of effort (in terms of policy, economic investment, and spatial extent) needed…
View article: Real-time quantitative reverse transcription polymerase chain reaction detection of SARS-CoV-2 Delta variant in Canadian wastewater
Real-time quantitative reverse transcription polymerase chain reaction detection of SARS-CoV-2 Delta variant in Canadian wastewater Open
This study demonstrates a novel cost-effective RT-qPCR assay for tracking the spread of the SARS-CoV-2 Delta variant. This rapid assay can be easily integrated into current wastewater surveillance programs to aid in population-level varian…
View article: Détection par la réaction en chaîne quantitative de la polymérase après transcription inverse en temps réel du variant Delta du SRAS-CoV-2 dans les eaux usées du Canada
Détection par la réaction en chaîne quantitative de la polymérase après transcription inverse en temps réel du variant Delta du SRAS-CoV-2 dans les eaux usées du Canada Open
View article: Genetic and Phenotypic Characterization of the First Canadian Case of Ambler Class A Carbapenemase FRI-8
Genetic and Phenotypic Characterization of the First Canadian Case of Ambler Class A Carbapenemase FRI-8 Open
This study investigated the mechanism of carbapenem resistance in an Enterobacter cloacae complex positive by the modified carbapenem inactivation method (mCIM) but negative by the Rosco Neo-Rapid Carb Kit, β CARBA, and conventional…
View article: Characterization of Escherichia coli and Other Enterobacterales Resistant to Extended-Spectrum Cephalosporins Isolated from Dairy Manure in Ontario, Canada
Characterization of Escherichia coli and Other Enterobacterales Resistant to Extended-Spectrum Cephalosporins Isolated from Dairy Manure in Ontario, Canada Open
The increase in antimicrobial resistance is of concern for human and animal health, especially when resistance is conferred to extended-spectrum cephalosporins, which are used to treat serious infections in both human and veterinary medici…
View article: Integrated surveillance of extended-spectrum beta-lactamase (ESBL)-producing <i>Salmonella</i> and <i>Escherichia coli</i> from humans and animal species raised for human consumption in Canada from 2012 to 2017
Integrated surveillance of extended-spectrum beta-lactamase (ESBL)-producing <i>Salmonella</i> and <i>Escherichia coli</i> from humans and animal species raised for human consumption in Canada from 2012 to 2017 Open
Resistance to beta-lactam antimicrobials caused by extended-spectrum beta-lactamase (ESBL)-producing organisms is a global health concern. The objectives of this study were to (1) summarise the prevalence of potential ESBL-producing Escher…
View article: Overview of Canada's Antimicrobial Resistance Network (AMRNet): A data-driven One Health approach to antimicrobial resistance surveillance
Overview of Canada's Antimicrobial Resistance Network (AMRNet): A data-driven One Health approach to antimicrobial resistance surveillance Open
The Antimicrobial Resistance Network (AMRNet) is a laboratory-based antimicrobial resistance (AMR) surveillance system under development at the Public Health Agency of Canada's (PHAC's) National Microbiology Laboratory. The AMRNet surveill…
View article: Sensibilités aux antimicrobiens du Neisseria gonorrhoeae au Canada, 2020
Sensibilités aux antimicrobiens du Neisseria gonorrhoeae au Canada, 2020 Open
Contexte : Le programme de surveillance antimicrobienne du gonocoque est un système de surveillance passive qui surveille la résistance du Neisseria gonorrhoeae aux antimicrobiens au Canada depuis les années 1980.Cet article résume les don…
View article: Aperçu du Réseau de la résistance aux antimicrobiens (RésRAM) du Canada : une approche Une seule santé axée sur les données pour la surveillance de la résistance aux antimicrobiens
Aperçu du Réseau de la résistance aux antimicrobiens (RésRAM) du Canada : une approche Une seule santé axée sur les données pour la surveillance de la résistance aux antimicrobiens Open
antimicrobiens (RésRAM) du Canada : une approche Une seule santé axée sur les données pour la surveillance de la résistance aux antimicrobiens.
View article: Antimicrobial susceptibilities of Neisseria gonorrhoeae in Canada, 2020
Antimicrobial susceptibilities of Neisseria gonorrhoeae in Canada, 2020 Open
Antimicrobial resistance in N. gonorrhoeae remains an important public health concern and continued surveillance is imperative to monitor trends to ensure the recommended therapies will be the most effective.
View article: Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America
Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America Open
View article: 89. On-going impact of the SARS-CoV-2 pandemic on the evolution of carbapenemase-producing <i>Enterobacterales</i> in Ontario, Canada
89. On-going impact of the SARS-CoV-2 pandemic on the evolution of carbapenemase-producing <i>Enterobacterales</i> in Ontario, Canada Open
Background The spread of carbapenemase-producing Enterobacterales (CPE) is global threat. Numerous outbreaks of CPE have been reported during the COVID-19 pandemic. We describe the impact of of the SARS-CoV-2 pandemic on the emergence of C…
View article: 668. Presence of the Narrow-Spectrum OXA-1 Beta-Lactamase Enzyme is not Associated with Elevated Ceftolozane-Tazobactam MIC Values among ESBL-Producing <i>Escherichia coli</i> Clinical Isolates (CANWARD, 2011-2018)
668. Presence of the Narrow-Spectrum OXA-1 Beta-Lactamase Enzyme is not Associated with Elevated Ceftolozane-Tazobactam MIC Values among ESBL-Producing <i>Escherichia coli</i> Clinical Isolates (CANWARD, 2011-2018) Open
Background Beta-lactam-beta-lactamase inhibitor combinations have been proposed as an alternative to carbapenems for the treatment of infections caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli as an antimicrobi…
View article: Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg Open
Antimicrobial resistance (AMR) has become a critical threat to public health worldwide. The use of antimicrobials in food and livestock agriculture, including the production of poultry, is thought to contribute to the dissemination of anti…
View article: Exploration of wastewater surveillance for Monkeypox virus
Exploration of wastewater surveillance for Monkeypox virus Open
The sudden emergence and spread of Monkeypox in non-endemic parts of the world is currently not well understood. Infections are often mis-diagnosed and surveillance strategies are scarce. Wastewater-based surveillance (WBS) of human Monkey…
View article: Surveillance des pneumococcies invasives au Canada, 2020
Surveillance des pneumococcies invasives au Canada, 2020 Open
Contexte : Les pneumococcies invasives (PI), qui sont causées par Streptococcus pneumoniae, sont des maladies à déclaration obligatoire au Canada depuis 2000.L'utilisation de vaccins conjugués a permis de réduire considérablement l'inciden…
View article: Surveillance des infections invasives à streptocoques du groupe A au Canada, 2020
Surveillance des infections invasives à streptocoques du groupe A au Canada, 2020 Open
Contexte : L'infection invasive à streptocoques du groupe A (IISGA) (causée par Streptococcus pyogenes) est une maladie à déclaration obligatoire au Canada depuis 2000.Cet article résume les données démographiques, les types emm et la rési…
View article: Invasive pneumococcal disease surveillance in Canada, 2020
Invasive pneumococcal disease surveillance in Canada, 2020 Open
Though the incidence of IPD decreased in 2020 in comparison to previous years across all age groups, disease due to PCV13 serotypes 3 and 4, as well as non-PCV13 serotypes such as 8 and 12F, increased in prevalence. Continued surveillance …
View article: Invasive group A streptococcal disease surveillance in Canada, 2020
Invasive group A streptococcal disease surveillance in Canada, 2020 Open
Though the number of collected invasive S. pyogenes isolates decreased slightly in 2020 in comparison to previous years, iGAS disease remains an important public health concern. The emm distribution in Canada has been subtly …