Michael R. Perkin
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View article: Food Allergy Prevention: Is Earlier Complementary Food Introduction Really the Optimal Approach?
Food Allergy Prevention: Is Earlier Complementary Food Introduction Really the Optimal Approach? Open
View article: Kinetics of early peanut allergy development and resolution in the EAT, LEAP, and PAS cohorts
Kinetics of early peanut allergy development and resolution in the EAT, LEAP, and PAS cohorts Open
A significant proportion of PA resolves in early childhood. Different phenotypes of PA display different biomarkers trajectories.
View article: Association Is Not Prediction—A Pervasive Issue in the Medical Literature
Association Is Not Prediction—A Pervasive Issue in the Medical Literature Open
View article: Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years
Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years Open
Proxy CHU9D in 2- to 5-year-old children shows potential but further research is needed.
View article: Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT
Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT Open
Background Atopic eczema is a common childhood skin problem linked with asthma, food allergy and allergic rhinitis that impairs quality of life. Objectives To determine whether advising parents to apply daily emollients in the first year c…
View article: Prevalence and risk factors for milk allergy overdiagnosis in the BEEP trial cohort
Prevalence and risk factors for milk allergy overdiagnosis in the BEEP trial cohort Open
Background Cow's milk allergy (CMA) overdiagnosis in young children appears to be increasing and has not been well characterised. We used a clinical trial population to characterise CMA overdiagnosis and identify individual‐level and prima…
View article: Biomarkers of peanut allergy in children over time
Biomarkers of peanut allergy in children over time Open
Background Various biomarkers are used to define peanut allergy (PA). We aimed to observe changes in PA resolution and persistence over time comparing biomarkers in PA and peanut sensitised but tolerant (PS) children in a population‐based …
View article: <scp>BabyBathe</scp> study protocol: A randomised controlled feasibility trial to change baby bathing practice during the first months of life
<span>BabyBathe</span> study protocol: A randomised controlled feasibility trial to change baby bathing practice during the first months of life Open
First paragraph: Eczema carries the highest global burden of all skin diseases and produces substantial disease-related morbidity worldwide and affects up to 15% of infants and 6% of older children. Eczema prevalence and time trends vary c…
View article: Development of an intervention for reducing infant bathing frequency
Development of an intervention for reducing infant bathing frequency Open
Background Bathing babies less frequently and intensively in the first six months of life may prevent eczema, but this has not yet been definitively tested in a randomised controlled trial. Such a trial would require evidence-based support…
View article: Biomarkers to predict changes in peanut allergy in children over time
Biomarkers to predict changes in peanut allergy in children over time Open
Background: Various biomarkers are used to define peanut allergy (PA). We aimed to observe changes in PA resolution and persistence over time comparing biomarkers in PA and peanut sensitised but tolerant (PS) children in a population-based…
View article: Routine infant skincare advice in the <scp>UK</scp>: A cross‐sectional survey
Routine infant skincare advice in the <span>UK</span>: A cross‐sectional survey Open
First paragraph: Eczema has the highest burden of all skin disease, affecting 15% of infants and 6% of older children worldwide.1 Gene–environment interactions are implicated in eczema development. Impaired skin barrier function is observe…
View article: Timing of complementary feeding for early childhood allergy prevention: An overview of systematic reviews
Timing of complementary feeding for early childhood allergy prevention: An overview of systematic reviews Open
Objective To summarise and critically appraise systematic review (SR) evidence on the effects of timing of complementary feeding (CF) on the occurrence of allergic sensitisation and disease. Design Overview of SRs. AMSTAR‐2 and ROBIS were …
View article: Efficacy and safety of ciclosporin versus methotrexate in the treatment of severe atopic dermatitis in children and young people (TREAT): a multicentre parallel group assessor-blinded clinical trial
Efficacy and safety of ciclosporin versus methotrexate in the treatment of severe atopic dermatitis in children and young people (TREAT): a multicentre parallel group assessor-blinded clinical trial Open
Background Conventional systemic drugs are used to treat children and young people (CYP) with severe atopic dermatitis (AD) worldwide, but no robust randomized controlled trial (RCT) evidence exists regarding their efficacy and safety in t…
View article: Emollients for preventing atopic eczema: Cost‐effectiveness analysis of the <scp>BEEP</scp> trial
Emollients for preventing atopic eczema: Cost‐effectiveness analysis of the <span>BEEP</span> trial Open
Background Recent discoveries have led to the suggestion that enhancing skin barrier from birth might prevent eczema and food allergy. Objective To determine the cost‐effectiveness of daily all‐over‐body application of emollient during the…
View article: Timing of Complementary Feeding for Early Childhood Allergy Prevention: An Overview of Systematic Reviews
Timing of Complementary Feeding for Early Childhood Allergy Prevention: An Overview of Systematic Reviews Open
Objective To summarise and critically appraise systematic review (SR) evidence on the effects of timing of complementary feeding (CF) on the occurrence of allergic sensitisation and disease. Design Overview of SRs. AMSTAR-2 and ROBIS were …
View article: Timing of Allergenic Food Introduction and Risk of Immunoglobulin E–Mediated Food Allergy
Timing of Allergenic Food Introduction and Risk of Immunoglobulin E–Mediated Food Allergy Open
Importance Earlier egg and peanut introduction probably reduces risk of egg and peanut allergy, respectively, but it is uncertain whether food allergy as a whole can be prevented using earlier allergenic food introduction. Objective To inv…
View article: Early introduction of peanut reduces peanut allergy across risk groups in pooled and causal inference analyses
Early introduction of peanut reduces peanut allergy across risk groups in pooled and causal inference analyses Open
Background The Learning Early About Peanut allergy (LEAP) study has shown the effectiveness of early peanut introduction in prevention of peanut allergy (PA). In the Enquiring About Tolerance (EAT) study, a statistically significant reduct…
View article: The hygiene hypothesis for allergy – conception and evolution
The hygiene hypothesis for allergy – conception and evolution Open
In 1989, a short paper entitled “Hay fever, hygiene and household size” observed that British children from larger families were less likely to develop hay fever and suggested that this could be because early exposure to infection prevents…
View article: Emollients for prevention of atopic dermatitis: 5‐year findings from the <scp>BEEP</scp> randomized trial
Emollients for prevention of atopic dermatitis: 5‐year findings from the <span>BEEP</span> randomized trial Open
Background The effectiveness of emollients for preventing atopic dermatitis/eczema is controversial. The Barrier Enhancement for Eczema Prevention trial evaluated the effects of daily emollients during the first year of life on atopic derm…
View article: National Survey of United Kingdom Paediatric Allergy Services
National Survey of United Kingdom Paediatric Allergy Services Open
Background Comprehensive national assessments of paediatric allergy services are rarely undertaken, and have never been undertaken in the United Kingdom. A 2006 survey estimated national capacity at 30,000 adult or paediatric new allergy a…
View article: Moving Complementary Feeding Forward
Moving Complementary Feeding Forward Open
The WHO Regional Office for Europe and the Federation of International Societies for Pediatric Gastroenterology, Hepatology, and Nutrition held a joint workshop, “Moving Complementary Feeding Forward” at the sixth World Congress Pediatric …
View article: Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol
Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol Open
Introduction Asthma is a growing health problem in children in marginalised urban settings in low-income and middle-income countries. Asthma attacks are an important cause of emergency care attendance and long-term morbidity. We designed a…
View article: Detection and management of milk allergy: Delphi consensus study
Detection and management of milk allergy: Delphi consensus study Open
Background There is significant overdiagnosis of milk allergy in young children in some countries, leading to unnecessary use of specialized formula. This guidance, developed by experts without commercial ties to the formula industry, aims…
View article: Frequency of guideline‐defined cow's milk allergy symptoms in infants: Secondary analysis of EAT trial data
Frequency of guideline‐defined cow's milk allergy symptoms in infants: Secondary analysis of EAT trial data Open
Background Non‐IgE‐mediated Cow's Milk Allergy (CMA) has a prevalence of less than 1% in children. Guidelines developed to help non‐specialists diagnose CMA may lead to misattribution of normal symptoms and contribute to overdiagnosis of C…
View article: The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol
The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol Open
Background: Research in early childhood allergy prevention (ECAP) is flourishing and new intervention strategies have proven to be promising. Due to the dynamic nature of ECAP, gaps between what is known and how guidelines inform practice …
View article: Adherence to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist in articles published in EAACI Journals: A bibliographic study
Adherence to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist in articles published in EAACI Journals: A bibliographic study Open
Research data derived from observational studies are accumulating quickly in the field of allergy and immunology and a large amount of observational studies are published every year. The aim of the present study was to evaluate the adheren…
View article: The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol
The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol Open
Background: Research in early childhood allergy prevention (ECAP) is flourishing and new intervention strategies have proven to be promising. Due to the dynamic nature of ECAP, gaps between what is known and how guidelines inform practice …
View article: Adherence to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist in articles published in EAACI Journals: a bibliographic study.
Adherence to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist in articles published in EAACI Journals: a bibliographic study. Open
Research data derived from observational studies are accumulating quickly in the field of allergy and immunology and a large amount of observational studies are published every year. The aim of the present study was to evaluate the adheren…
View article: Association of frequent moisturizer use in early infancy with the development of food allergy
Association of frequent moisturizer use in early infancy with the development of food allergy Open
View article: Gut microbiota development during infancy: Impact of introducing allergenic foods
Gut microbiota development during infancy: Impact of introducing allergenic foods Open