Michael R. Hamblin
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View article: Distinguishing amyotrophic lateral sclerosis from radiculopathy using machine learning to analyze nerve conduction data
Distinguishing amyotrophic lateral sclerosis from radiculopathy using machine learning to analyze nerve conduction data Open
Amyotrophic lateral sclerosis (ALS) is a rare, fatal, and irreversible disease that shares some key clinical features with radiculopathy, including muscle atrophy, muscle cramps, and fasciculation. The aim of this study was to find a relia…
View article: Femtosecond laser irradiation has an anti-virulence effect by reducing the adhesion and invasion of MRSA bacteria to human cells: an in vitro study
Femtosecond laser irradiation has an anti-virulence effect by reducing the adhesion and invasion of MRSA bacteria to human cells: an in vitro study Open
Purpose Multidrug-resistant bacterial infections are a substantial global health challenge. Targeting bacterial virulence factors that control the progression, severity, and pathogenicity of bacterial infections could prevent and combat in…
View article: Biomaterials for CNS disorders: a review of development from traditional methods to AI-assisted optimization
Biomaterials for CNS disorders: a review of development from traditional methods to AI-assisted optimization Open
Treating neurodegenerative and traumatic brain disorders is profoundly challenging due to factors like permanent tissue loss and the restrictive nature of the Blood-Brain Barrier (BBB), which limits drug delivery to the brain. Biomaterials…
View article: Effects of Photobiomodulation on Nervous System Disorders: A Narrative Review
Effects of Photobiomodulation on Nervous System Disorders: A Narrative Review Open
Introduction: Photobiomodulation (PBM), also known as low-level laser therapy (LLLT), has emerged as a potential therapeutic strategy for various nervous system disorders. Its biological effects on neural tissue are primarily mediated by t…
View article: 5-Hydroxytryptamine receptors in GtoPdb v.2025.3
5-Hydroxytryptamine receptors in GtoPdb v.2025.3 Open
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [201] and subsequently revised [183]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. …
View article: Low-Level Light Therapy Effect on Metabolites measured by Magnetic Resonance Spectroscopy in Patients with Moderate Traumatic Brain Injury: A Double-blind, Randomized, Placebo-controlled Clinical Trial
Low-Level Light Therapy Effect on Metabolites measured by Magnetic Resonance Spectroscopy in Patients with Moderate Traumatic Brain Injury: A Double-blind, Randomized, Placebo-controlled Clinical Trial Open
LLLT＝Low-level light therapy; TBI＝traumatic brain injury; MRSI = magnetic resonance spectroscopic imaging; CC = corpus callosum; mI = in myo-inositol; NAA = N-acetyl aspartate; ATP = adenosine triphosphate; GCS = Glasgow Coma Scale; LASER …
View article: A Lipid with Lewis Pair‐Mediated Targeting and Multiple Stimuli‐Responsive Delivery of Antibiotics for Bacterial Infections
A Lipid with Lewis Pair‐Mediated Targeting and Multiple Stimuli‐Responsive Delivery of Antibiotics for Bacterial Infections Open
Integrating both targeted delivery and stimulus‐responsive release into a single small molecule for drug delivery presents challenges related to synthesis, stability, and efficacy. In this study, single‐molecular lipids incorporating a Lew…
View article: When the victim becomes the villain: Platelets as drivers of immune dysregulation in ITP
When the victim becomes the villain: Platelets as drivers of immune dysregulation in ITP Open
Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterized by immune-mediated destruction of platelets and impaired platelet production. Although autoantibodies have historically been central to the understanding of…
View article: Nanodrug-based modulation of platelet–leukocyte interactions in ovarian cancer: a new frontier in targeted therapy
Nanodrug-based modulation of platelet–leukocyte interactions in ovarian cancer: a new frontier in targeted therapy Open
Ovarian cancer (OC) remains a leading cause of gynecologic cancer mortality due to its biological heterogeneity, late-stage diagnosis, and resistance to conventional therapies. The tumor microenvironment (TME) plays a critical role in driv…
View article: Enhanced killing of ocular melanoma cells by combining femtosecond laser light with laser-ablated CuO nanoparticles
Enhanced killing of ocular melanoma cells by combining femtosecond laser light with laser-ablated CuO nanoparticles Open
Skin cancer is the leading type of cancer worldwide, divided into two main categories: melanoma and non-melanoma skin cancer. In addition to cutaneous melanoma, ocular melanoma affects the eye and urgently requires innovative therapeutic a…
View article: Gut microbiota modulation: a key determinant of atopic dermatitis susceptibility in children
Gut microbiota modulation: a key determinant of atopic dermatitis susceptibility in children Open
Atopic dermatitis is a chronic inflammatory skin condition with a higher incidence rate among children. In recent years, the role of the gut microbiota in the pathogenesis of atopic dermatitis has garnered increasing attention. This review…
View article: 5-Hydroxytryptamine receptors in GtoPdb v.2025.1
5-Hydroxytryptamine receptors in GtoPdb v.2025.1 Open
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [200] and subsequently revised [182]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. …
View article: Self-replicating nanomaterials as a new generation of smart nanostructures
Self-replicating nanomaterials as a new generation of smart nanostructures Open
Self-replication is the process by which a system or entity autonomously reproduces or generates copies of itself, transmitting hereditary information through its molecular structure. Self-replication can be attractive for various research…
View article: The dual role of chaperone-mediated autophagy in the response and resistance to cancer immunotherapy
The dual role of chaperone-mediated autophagy in the response and resistance to cancer immunotherapy Open
Cancer immunotherapy has become a revolutionary strategy in oncology, utilizing the host immune system to fight malignancies. Notwithstanding major progress, obstacles such as immune evasion by tumors and the development of resistance stil…
View article: The effects of peptide IF7-conjugated dendrimer loaded with doxorubicin on colorectal cancer
The effects of peptide IF7-conjugated dendrimer loaded with doxorubicin on colorectal cancer Open
We assessed the therapeutic potential of a combination of dendrimer generation 2 (G2) + doxorubicin (DOX) + peptide IF7 on colorectal cells. The researchers utilized regular examinations to assess the dimensions, structure, distribution, a…
View article: Advanced drug delivery platforms target cancer stem cells
Advanced drug delivery platforms target cancer stem cells Open
Cancer stem cells (CSCs) are a major challenge in cancer therapy. Stem cell-like cells form a unique subpopulation within many tumors, which govern the degree of malignancy by promoting metastasis, recurrence, heterogeneity, and resistance…
View article: Functional Recovery Promotion After Spinal Cord Injury With Astaxanthin Treatment in Preclinical Studies: A Systematic Review and Meta‐Analysis
Functional Recovery Promotion After Spinal Cord Injury With Astaxanthin Treatment in Preclinical Studies: A Systematic Review and Meta‐Analysis Open
Introduction: Due to anti‐inflammatory, antioxidant, immune‐modulating, and antiaging properties of astaxanthin, it has been used to treat spinal cord injuries (SCIs). In this meta‐analysis study, the effects of astaxanthin on SCI in anima…
View article: 4‐Methylumbelliferone (4‐MU) Improves Learning and Memory After Cerebral Ischemia/Reperfusion Injury in Rats
4‐Methylumbelliferone (4‐MU) Improves Learning and Memory After Cerebral Ischemia/Reperfusion Injury in Rats Open
Background Stroke is the sixth leading cause of death and lifelong disability for millions of people in the United States. Cerebral ischemia leads to oxidative stress, excitotoxicity, inflammation, and apoptosis; additionally, impairment i…
View article: 4-Methyllumifrone (4-MU) can improve learning and memory after cerebral ischemia/reperfusion injury in rats
4-Methyllumifrone (4-MU) can improve learning and memory after cerebral ischemia/reperfusion injury in rats Open
Background Stroke is the sixth leading cause of death and lifelong disability for millions of people in the United States. Cerebral ischemia leads to oxidative stress, excitotoxicity, inflammation, apoptosis; additionally, impairments in m…