Explanipedia

Hyperkalemia in liver transplantation Open

William Chang, M.K. Xu, Alexander George, Meredith Kingeter, C. Patrick Henson , et al. · 2025

Hyperkalemia commonly occurs in patients undergoing liver transplantation. The intraoperative course of liver transplant often involves hemodynamic and metabolic derangements leading up to liver reperfusion. Potassium levels can rise to da…

10 degree C static storage of porcine donation after circulatory death livers improves biliary viability and mitigates ischemia-reperfusion injury Open

Kaitlyn M. Tracy, Yutaka Shishido, Mark Petrovic, Alexandria C. Murphy, TiOluwanimi Adesanya , et al. · 2025

24-hour normothermic machine perfusion of discarded human liver grafts: Case series single-center study Open

Adhnan Mohamed, Tayseer Shamaa, Iman Francis, Catherine Crombez, Jennifer Y. Cui , et al. · 2023

The persistent shortage of liver allografts contributes to significant waitlist mortality. Normothermic machine perfusion (NMP) has the potential to extend viability and allow liver function evaluation in discarded organs. The main aim of …

Variation of Liver Transplant Practice and Outcomes During Public Holidays in the United States: Analysis of United Network for Organ Sharing Registry Open

Tayseer Shamaa, Toshihiro Kitajima, Tommy Ivanics, Shingo Shimada, Adhnan Mohamed , et al. · 2023

Background: It has been reported that patients hospitalized outside regular working hours have worse outcomes. This study aims to compare outcomes following liver transplantation (LT) performed during public holidays and nonholidays. Metho…

Disparities in the Effects of Acuity Circle–based Liver Allocation on Waitlist and Transplant Practice Between Centers Open

Shunji Nagai, Tommy Ivanics, Toshihiro Kitajima, Shingo Shimada, Tayseer Shamaa , et al. · 2022

Background. Liver allocation in the United States was updated on February 4, 2020, by introducing the acuity circle (AC)–based model. This study evaluated the early effects of the AC-based allocation on waitlist outcomes. Methods. Adult li…

Liver Transplant Recipient Characteristics Associated With Worse Post-Transplant Outcomes in Using Elderly Donors Open

Shingo Shimada, Tayseer Shamaa, Tommy Ivanics, Toshihiro Kitajima, Kelly Collins , et al. · 2022

Advanced age of liver donor is a risk factor for graft loss after transplant. We sought to identify recipient characteristics associated with negative post-liver transplant (LT) outcomes in the context of elderly donors. Using 2014–2019 OP…

Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant Open

James F. Markmann, Marwan Abouljoud, R. Mark Ghobrial, Chandra Bhati, Shawn J. Pelletier , et al. · 2022

ClinicalTrials.gov Identifier: NCT02522871.

Effect of Season and Climate Regions on Liver Transplant Waitlist and Post-Transplant Outcomes: Analysis of United Network for Organ Sharing Registry Open

Tayseer Shamaa, Toshihiro Kitajima, Tommy Ivanics, Shingo Shimada, Sirisha Yeddula , et al. · 2022

Extreme hyponatremia as a risk factor for early mortality after liver transplantation in the MELD‐sodium era Open

Tommy Ivanics, Shravan Leonard‐Murali, Hassan Mouzaihem, Dilip Moonka, Toshihiro Kitajima , et al. · 2021

The impact of hyponatremia on waitlist and post-transplant outcomes following the implementation of MELD-Na-based liver allocation remains unclear. We investigated waitlist and postliver transplant (LT) outcomes in patients with hyponatrem…

Design, Analysis, and Pitfalls of Clinical Trials Using Ex Situ Liver Machine Perfusion: The International Liver Transplantation Society Consensus Guidelines Open

Paulo N. Martins, Michael Rizzari, Davide Ghinolfi, Ina Jochmans, Magdy Attia , et al. · 2021

Background. Recent trials in liver machine perfusion (MP) have revealed unique challenges beyond those seen in most clinical studies. Correct trial design and interpretation of data are essential to avoid drawing conclusions that may compr…

A comparison of rates and severity of chronic kidney disease in deceased-donor and living-donor liver transplant recipients: times matter Open

Yücel Yankol, Emily Bugeaud, Tiffany Zens, Michael Rizzari, Nesimi Mecit , et al. · 2020

It can be concluded that LDLT provides excellent graft and patient survival, significantly reducing the overall incidence of clinically significant CKD stage progression when compared to DDLT. Moreover, there is a significantly higher inci…

Retransplantation outcomes for hepatitis C in the United States before and after direct-acting antiviral introduction Open

Tommy Ivanics, Michael Rizzari, Dilip Moonka, Abbas Al‐Kurd, Khortnal Delvecchio , et al. · 2020

The success of direct-acting antiviral (DAA) therapy has led to near-universal cure for patients chronically infected with hepatitis C virus (HCV) and improved post-liver transplant (LT) outcomes. We investigated the trends and outcomes of…

A Share 21 model in liver transplantation: Impact on waitlist outcomes Open

Shunji Nagai, Lucy Chau, Toshihiro Kitajima, Sirisha Yeddula, Kelly Collins , et al. · 2020

With the introduction of Model for End-Stage Liver Disease-Sodium (MELD-Na)-based allocation, the score at which patients benefit from liver transplantation (LT) has shifted from a score of 15 to 21. This study aimed to evaluate waitlist o…

Combined Chylothorax and Chylous Ascites Complicating Liver Transplantation: A Report of a Case and Review of the Literature Open

Tommy Ivanics, Semeret Munie, Hassan Nasser, Shravan Leonard‐Murali, Atsushi Yoshida , et al. · 2019

Chyle leaks may occur as a result of surgical intervention. Chyloperitoneum, or chylous ascites after liver transplantation, is rare and the development of chylothorax after abdominal surgery is even more rare. With increasingly aggressive…

Inferior Liver Transplant Outcomes in Patients with Nonalcoholic Steatohepatitis Open

Shunji Nagai, Kelly Collins, Lucy Chau, Mohamed Safwan, Michael Rizzari , et al. · 2019

Effects of Allocating Livers for Transplantation Based on Model for End-Stage Liver Disease–Sodium Scores on Patient Outcomes Open

Shunji Nagai, Lucy Chau, Randolph Schilke, Mohamed Safwan, Michael Rizzari , et al. · 2018

Liver alone or simultaneous liver-kidney transplant? Pretransplant chronic kidney disease and post-transplant outcome - a retrospective study Open

Shunji Nagai, Mohamed Safwan, Kelly Collins, Randolph Schilke, Michael Rizzari , et al. · 2018

The new Organ Procurement and Transplant Network/United Organ Sharing Network (OPTN/UNOS) simultaneous liver-kidney transplant (SLK) policy has been implemented. The aim of this study was to review liver transplant outcomes utilizing the n…

Impact of abdominal shape on living liver donor outcomes in mini‐incision right hepatic lobectomy: Comparison among 3 techniques Open

Mohamed Safwan, Shunji Nagai, Kelly Collins, Michael Rizzari, Atsushi Yoshida , et al. · 2017

Although minimally invasive techniques for living donor hepatectomy have been developed, the surgical feasibility and limitations remain to be elucidated. The risks and outcomes involved need to be better understood prior to their widespre…

Continuous Quadrupole Magnetic Separation of Islets during Digestion Improves Purified Porcine Islet Viability Open

Bradley P. Weegman, Venkata Sunil Kumar Sajja, Thomas M. Suszynski, Michael Rizzari, William E. Scott , et al. · 2016

Islet transplantation (ITx) is an emerging and promising therapy for patients with uncontrolled type 1 diabetes. The islet isolation and purification processes require exposure to extended cold ischemia, warm-enzymatic digestion, mechanica…

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