Michael Rullmann
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View article: Role of physical fitness in resistance and cognitive resilience against age‐related pathology
Role of physical fitness in resistance and cognitive resilience against age‐related pathology Open
Background Cognitive reserve (CR) and brain maintenance enable the brain to maintain performance despite injury and disease while also reducing neural decline by safeguarding brain structure and function. Physical activity is a potential p…
View article: Episodic memory network connectivity with aging and Alzheimer’s disease pathology in cognitively unimpaired older adults
Episodic memory network connectivity with aging and Alzheimer’s disease pathology in cognitively unimpaired older adults Open
Background Regions of the medial temporal lobe and posteromedial cortex are crucial for episodic memory and are among the first to be affected by Alzheimer´s disease (AD) pathology. Hyperconnectivity in association with amyloid and tau pat…
View article: Hybrid Tau-PET/MRI study: Quantitative susceptibility mapping in progressive supranuclear palsy and its correlation with Tau-PET
Hybrid Tau-PET/MRI study: Quantitative susceptibility mapping in progressive supranuclear palsy and its correlation with Tau-PET Open
Introduction The atypical Parkinsonian disorder progressive supranuclear palsy (PSP) forms a diagnostic challenge, resulting in frequent misdiagnosis and delay in treatment. Although structural MRI can detect PSP signs at more advanced sta…
View article: NEMA NU2 2018 Performance Evaluation of the NeuroLF 10mm Version "Basic" Brain PET Scanner
NEMA NU2 2018 Performance Evaluation of the NeuroLF 10mm Version "Basic" Brain PET Scanner Open
Background: This work presents the NEMA NU2 2018 performance evaluation of the NeuroLF Basic, a compact and fully integrated brain positron emission tomography (PET) system based on 10-mm-long LYSO crystals. The evaluation includes measure…
View article: Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease
Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease Open
The link between regional tau load and clinical manifestation of Alzheimer’s disease (AD) highlights the importance of characterizing spatial tau distribution across disease variants. In typical (memory-predominant) AD, the spatial progres…
View article: The relationship between α4β2-nicotinic acetylcholine receptor availability and brain arousal regulation as assessed by 2-[18F]F-A85380 PET and EEG following nicotine cessation in male individuals with nicotine dependence
The relationship between α4β2-nicotinic acetylcholine receptor availability and brain arousal regulation as assessed by 2-[18F]F-A85380 PET and EEG following nicotine cessation in male individuals with nicotine dependence Open
The findings may suggest that the brain arousal regulation in some of the male participants may become more instable following a 7-day smoking cessation despite increased α4β2-nAChR binding. However, this sample limits the generalizability…
View article: Biological tumor volume predicts survival in recurrent High-Grade glioma: A multiparametric [18F]FET PET/MRI study
Biological tumor volume predicts survival in recurrent High-Grade glioma: A multiparametric [18F]FET PET/MRI study Open
Background and purpose Single-session, multiparametric [¹⁸F]FET PET/MRI is used to detect tumor recurrence in high-grade glioma, but its prognostic value for overall survival remains uncertain. This study evaluated whether biological tumor…
View article: Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex
Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex Open
Tau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer’s disease, which is associated with neurodegeneration and cognitive decline. Understanding how demographic, clinical and genetic fact…
View article: Retrospective Evaluation of Baseline Amino Acid PET for Identifying Future Regions of Tumor Recurrence in High-Grade Glioma Patients
Retrospective Evaluation of Baseline Amino Acid PET for Identifying Future Regions of Tumor Recurrence in High-Grade Glioma Patients Open
Background/Objectives: Positron emission tomography (PET) imaging with radiolabeled amino acids is increasingly used in glioma patients for biopsy planning, tumor delineation, prognostication, and therapy response assessment. This study in…
View article: Impact of white matter hyperintensities on α4β2 nicotinic acetylcholine receptor binding in the human brain
Impact of white matter hyperintensities on α4β2 nicotinic acetylcholine receptor binding in the human brain Open
Purpose White matter hyperintensities (WMHs) are commonly observed in aging and neurodegenerative diseases, but their impact on the α4β2 nicotinic acetylcholine receptor (α4β2-nAChR) system remains unclear. This study investigates the rela…
View article: Long COVID – a critical disruption of cholinergic neurotransmission?
Long COVID – a critical disruption of cholinergic neurotransmission? Open
Background Following the COVID-19 pandemic, there are many chronically ill Long COVID (LC) patients with different symptoms of varying degrees of severity. The pathological pathways of LC remain unclear until recently and make identificati…
View article: Multi-parametric [18F]PI-2620 tau PET/MRI for the phenotyping of different Alzheimer’s disease variants
Multi-parametric [18F]PI-2620 tau PET/MRI for the phenotyping of different Alzheimer’s disease variants Open
Purpose Heterogeneity in clinical phenotypes has led to the description of different phenotypes of Alzheimer’s disease (AD). Besides the most frequent amnestic variant of AD (aAD), patients presenting with language deficits are diagnosed w…
View article: Assessment and staging of A/T/N with a single dynamic [<sup>18</sup>F]PI-2620 recording
Assessment and staging of A/T/N with a single dynamic [<sup>18</sup>F]PI-2620 recording Open
Patients with Alzheimer’s disease (AD) and clinically overlapping neurodegenerative diseases are classified molecularly using the A/T/N classification system. Apart from fluid biomarkers and structural MRI, the three-dimensional A/T/N syst…
View article: Molecular connectivity studies in neurotransmission: a scoping review
Molecular connectivity studies in neurotransmission: a scoping review Open
Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are essential molecular imaging tools for the in vivo investigation of neurotransmission. Traditionally, PET and SPECT images are analysed in a univa…
View article: Abnormalities of iron homeostasis and the dopaminergic system in Tourette syndrome revealed by 7T MRI and PET
Abnormalities of iron homeostasis and the dopaminergic system in Tourette syndrome revealed by 7T MRI and PET Open
While the implication of a dysfunctional dopaminergic system in Tourette syndrome (TS) is well established, the underlying pathophysiological mechanisms remain unclear. Apart from neurotransmitters, disturbed iron homeostasis and iron regu…
View article: Connectivity as a universal predictor of tau spreading in typical and atypical Alzheimer’s disease
Connectivity as a universal predictor of tau spreading in typical and atypical Alzheimer’s disease Open
Background There is a strong link between tau and progression of Alzheimer’s disease (AD), necessitating an understanding of tau spreading mechanisms. Prior research, predominantly in typical AD, suggested that tau propagates from epicente…
View article: The prevalence of tau‐PET positivity in aging and dementia
The prevalence of tau‐PET positivity in aging and dementia Open
Background Tau‐PET imaging allows in‐vivo detection of neurofibrillary tangles. One tau‐PET tracer (i.e., [ 18 F]flortaucipir) has received FDA‐approval for clinical use, and multiple other tau‐PET tracers have been implemented into clinic…
View article: Connectivity as a universal predictor of tau spreading in typical and atypical Alzheimer’s disease
Connectivity as a universal predictor of tau spreading in typical and atypical Alzheimer’s disease Open
Background There is a strong link between tau and progression of Alzheimer’s disease (AD), necessitating an understanding of tau spreading mechanisms. Prior research, predominantly in typical AD, suggested that tau propagates from epicente…
View article: Multimodal phenotyping of successful cognitive aging
Multimodal phenotyping of successful cognitive aging Open
Background While some memory decline in old age is “normal”, there are some older individuals with maintained high cognitive performance. Using a multimodal approach including neuroimaging, fitness, genetic and questionnaire data (Fig1A), …
View article: Multimodal phenotyping of successful cognitive aging
Multimodal phenotyping of successful cognitive aging Open
Background While some memory decline in old age is “normal”, there are some older individuals with maintained high cognitive performance. Using a multimodal approach including neuroimaging, fitness, genetic and questionnaire data (Figure 1…
View article: The prevalence of tau‐PET positivity in aging and dementia
The prevalence of tau‐PET positivity in aging and dementia Open
Background Tau‐PET imaging allows in‐vivo detection of neurofibrillary tangles. One tau‐PET tracer (i.e., [18F]flortaucipir) has received FDA‐approval for clinical use, and multiple other tau‐PET tracers have been implemented into clinical…
View article: Molecular connectivity studies in neurotransmission: a scoping review
Molecular connectivity studies in neurotransmission: a scoping review Open
Purpose: Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are essential molecular imaging tools for the in vivo investigation of neurotransmission. Traditionally, PET and SPECT images are analysed i…
View article: Detection of cancer‐associated cachexia in lung cancer patients using whole‐body [<sup>18</sup>F]FDG‐PET/CT imaging: A multi‐centre study
Detection of cancer‐associated cachexia in lung cancer patients using whole‐body [<sup>18</sup>F]FDG‐PET/CT imaging: A multi‐centre study Open
Background Cancer‐associated cachexia (CAC) is a metabolic syndrome contributing to therapy resistance and mortality in lung cancer patients (LCP). CAC is typically defined using clinical non‐imaging criteria. Given the metabolic underpinn…
View article: Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [<sup>18</sup>F]PI-2620
Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [<sup>18</sup>F]PI-2620 Open
We used a new data-driven methodology to identify a set of reference regions that enhanced the quantification of the SUV ratio of the second-generation tau tracer 2-(2-([18F]fluoro)pyridin-4-yl)-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-…
View article: “Metabolic fingerprints” of cachexia in lung cancer patients
“Metabolic fingerprints” of cachexia in lung cancer patients Open
Our European consortium was awarded research funding from the EraPerMED consortium [14] (LuCaPET project, grant number ERAPerMed_324, “Clinical decision support for predicting cachexia in cancer patients using hybrid PET/CT imaging”) to st…
View article: Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies
Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies Open
Purpose We hypothesized that severe tau burden in brain regions involved in direct or indirect pathways of the basal ganglia correlate with more severe striatal dopamine deficiency in four-repeat (4R) tauopathies. Therefore, we correlated …
View article: Motor learning is modulated by dopamine availability in the sensorimotor putamen
Motor learning is modulated by dopamine availability in the sensorimotor putamen Open
Successful motor skill acquisition requires the dynamic interaction of multiple brain regions, with the striatum playing a critical role in this network. Animal studies suggest that dopaminergic mechanisms are involved in the regulation of…