Michael Safaee
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View article: Evaluating the Accuracy and Readability of ChatGPT in Addressing Patient Queries on Adult Spinal Deformity Surgery
Evaluating the Accuracy and Readability of ChatGPT in Addressing Patient Queries on Adult Spinal Deformity Surgery Open
Study Design Cross-Sectional. Objectives Adult spinal deformity (ASD) affects 68% of the elderly, with surgical intervention carrying complication rates of up to 50%. Effective patient education is essential for managing expectations, yet …
View article: Underutilization of preoperative osteoporosis screening and treatment in a national sample of patients with adult spinal deformity
Underutilization of preoperative osteoporosis screening and treatment in a national sample of patients with adult spinal deformity Open
OBJECTIVE Osteoporosis contributes to mechanical complications, such as pedicle screw loosening, instrumentation failure, and pseudarthrosis, following adult spinal deformity (ASD) correction surgery. Research has shown that preoperative m…
View article: A Spine-Specific Lexicon for the Sentiment Analysis of Interviews with Adult Spinal Deformity Patients Correlates with SF-36, SRS-22, and ODI Scores: A Pilot Study of 25 Patients
A Spine-Specific Lexicon for the Sentiment Analysis of Interviews with Adult Spinal Deformity Patients Correlates with SF-36, SRS-22, and ODI Scores: A Pilot Study of 25 Patients Open
Classic health-related quality of life (HRQOL) metrics are cumbersome, time-intensive, and subject to biases based on the patient’s native language, educational level, and cultural values. Natural language processing (NLP) converts text in…
View article: The Effect of Osteoporosis on Complications and Reoperation Rates After Surgical Management of Adult Thoracolumbar Spinal Deformity: A Systematic Review and Meta Analysis
The Effect of Osteoporosis on Complications and Reoperation Rates After Surgical Management of Adult Thoracolumbar Spinal Deformity: A Systematic Review and Meta Analysis Open
Study Design Systematic Review. Objectives While substantial research has explored the impact of osteoporosis on patients undergoing adult spinal deformity (ASD) correction, the literature remains inconclusive. As such, the purpose of this…
View article: Biomarkers in adult spinal deformity surgery
Biomarkers in adult spinal deformity surgery Open
Outcomes following adult spinal deformity (ASD) surgery vary, despite technical advances and improved patient selection. Current prediction models, comprised of clinical and radiographic parameters, do not fully explain observed variation …
View article: Future Data Points to Implement in Adult Spinal Deformity Assessment for Artificial Intelligence Modeling Prediction: The Importance of the Biological Dimension
Future Data Points to Implement in Adult Spinal Deformity Assessment for Artificial Intelligence Modeling Prediction: The Importance of the Biological Dimension Open
Adult spinal deformity (ASD) surgery is still associated with high surgical risks. Machine learning algorithms applied to multicenter databases have been created to predict outcomes and complications, optimize patient selection, and improv…
View article: WITHDRAWN: Epigenetic clocks and risk assessment in adult spinal deformity: A novel association between pace of aging with frailty, disability, and postoperative complications
WITHDRAWN: Epigenetic clocks and risk assessment in adult spinal deformity: A novel association between pace of aging with frailty, disability, and postoperative complications Open
Withdrawal statement The authors have withdrawn their manuscript owing to altered the findings and conclusions related to complication data. The changes in results were due to further scrutiny of the datasets, and led to the removal of 3 p…
View article: Data from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages
Data from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages Open
Purpose: Gliomas are known to induce local and systemic immunosuppression, inhibiting T-cell–mediated cytotoxic responses to tumor growth. Tumor-associated macrophages are a significant component of the immune infiltrate in gliomas and may…
View article: Data from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages
Data from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages Open
Purpose: Gliomas are known to induce local and systemic immunosuppression, inhibiting T-cell–mediated cytotoxic responses to tumor growth. Tumor-associated macrophages are a significant component of the immune infiltrate in gliomas and may…
View article: Patient Frailty Influences Outcome After Open, But Not Minimally Invasive, Transforaminal Interbody Fusion: A Case Series of 115 Patients With Lumbar Degenerative Disease
Patient Frailty Influences Outcome After Open, But Not Minimally Invasive, Transforaminal Interbody Fusion: A Case Series of 115 Patients With Lumbar Degenerative Disease Open
BACKGROUND: For transforaminal lumbar interbody fusion (TLIF), there are equally good open and minimally invasive surgery (MIS) options. OBJECTIVE: To determine if frailty has a differential effect on outcome for open vs MIS TLIF. METHODS:…
View article: Telemedicine in Neurosurgery: Standardizing the Spinal Physical Examination Using A Modified Delphi Method
Telemedicine in Neurosurgery: Standardizing the Spinal Physical Examination Using A Modified Delphi Method Open
The resulting protocol was used in our clinic to standardize the telehealth strength examination. This protocol, as well as our summary of telehealth clinical practice, should aid neurosurgical clinics in integrating telemedicine modalitie…
View article: CSIG-04. ROLE OF c-Met/β1 INTEGRIN COMPLEX IN THE METASTATIC CASCADE
CSIG-04. ROLE OF c-Met/β1 INTEGRIN COMPLEX IN THE METASTATIC CASCADE Open
Metastases cause 90% of human cancer deaths. The metastatic cascade involves 5 steps: local invasion, intravasation, extravasation, metastatic site colonization, and proliferation. While individual mediators of these processes have been in…
View article: Commentary on Vertebral Body Sliding Osteotomy for Cervical Myelopathy With Rigid Kyphosis: A Technical Note
Commentary on Vertebral Body Sliding Osteotomy for Cervical Myelopathy With Rigid Kyphosis: A Technical Note Open
See the article "Vertebral Body Sliding Osteotomy for Cervical Myelopathy With Rigid Kyphosis" in Volume 17 on page 640.
View article: The Effect of Systemic Tranexamic Acid on Hypercoagulable Complications and Perioperative Outcomes Following Three-Column Osteotomy for Adult Spinal Deformity
The Effect of Systemic Tranexamic Acid on Hypercoagulable Complications and Perioperative Outcomes Following Three-Column Osteotomy for Adult Spinal Deformity Open
Study Design: Retrospective cohort study. Objective: Thoracolumbar 3-column osteotomy (3CO) is a powerful technique for correction of rigid adult spinal deformity (ASD). However, it can be associated with high-volume blood loss. This study…
View article: The effect of anterior lumbar interbody fusion staging order on perioperative complications in circumferential lumbar fusions performed within the same hospital admission
The effect of anterior lumbar interbody fusion staging order on perioperative complications in circumferential lumbar fusions performed within the same hospital admission Open
OBJECTIVE Anterior lumbar interbody fusion (ALIF) is a powerful technique that provides wide access to the disc space and allows for large lordotic grafts. When used with posterior spinal fusion (PSF), the procedures are often staged withi…
View article: Trends in Posterior Cervical Fusion for Deformity in the United States from 2000 to 2017
Trends in Posterior Cervical Fusion for Deformity in the United States from 2000 to 2017 Open
BACKGROUND Posterior cervical decompression and fusion (PCF) is a common treatment for cervical spondylotic myelopathy. Treatment paradigms are shifting from simple decompression and fusion to correcting cervical deformities. OBJECTIVE To …
View article: The impact of obesity on perioperative complications in patients undergoing anterior lumbar interbody fusion
The impact of obesity on perioperative complications in patients undergoing anterior lumbar interbody fusion Open
OBJECTIVE Anterior approaches to the lumbar spine provide wide exposure that facilitates placement of large grafts with high fusion rates. There are limited data on the effects of obesity on perioperative complications. METHODS Data from c…
View article: Role of c-Met/β1 integrin complex in the metastatic cascade
Role of c-Met/β1 integrin complex in the metastatic cascade Open
Metastases cause 90% of human cancer deaths. The metastatic cascade involves local invasion, intravasation, extravasation, metastatic site colonization, and proliferation. While individual mediators of these processes have been investigate…
View article: Posterior osteotomy techniques for rigid cervical deformity correction
Posterior osteotomy techniques for rigid cervical deformity correction Open
Posterior cervical osteotomies are powerful techniques for the correction of rigid cervical deformity. These include a variety of subtypes including partial facet joint resection, complete facet joint resection, opening wedge osteotomy (OW…
View article: Anterior osteotomy for rigid cervical deformity correction
Anterior osteotomy for rigid cervical deformity correction Open
Rigid deformities of the cervical spine can be associated with significant pain, disability, and impaired quality of life. Historical treatments generally utilized posterior approaches including the opening wedge osteotomy and pedicle subt…
View article: Safety and efficacy of direct nerve root decompression via anterior cervical discectomy and fusion with uncinectomy for cervical radiculopathy
Safety and efficacy of direct nerve root decompression via anterior cervical discectomy and fusion with uncinectomy for cervical radiculopathy Open
Cervical radiculopathy is a common spinal condition associated with pain, sensory disturbances, and motor weakness. Symptoms often can be attributable to either disc herniation and/or bony foraminal stenosis due to uncinate hypertrophy. Po…
View article: TMIC-22. IDENTIFICATION OF CANCER-ASSOCIATED FIBROBLASTS IN GLIOBLASTOMA and Defining Their Protumoral Effects
TMIC-22. IDENTIFICATION OF CANCER-ASSOCIATED FIBROBLASTS IN GLIOBLASTOMA and Defining Their Protumoral Effects Open
While cancer-associated fibroblasts (CAFs) and their pro-tumoral effects have been demonstrated in systemic cancers, CAFs had been presumed absent in glioblastoma given the lack of normal fibroblasts in the healthy brain. Here, we show tha…
View article: TMIC-57. PRO-TUMORAL EFFECTS OF INTRA-TUMORAL NEUTROPHILS IN THE GLIOBLASTOMA MICROENVIRONMENT
TMIC-57. PRO-TUMORAL EFFECTS OF INTRA-TUMORAL NEUTROPHILS IN THE GLIOBLASTOMA MICROENVIRONMENT Open
While macrophage enrichment and lymphocyte depletion have been described in glioblastoma, intratumoral neutrophils and their effect on glioblastoma have been under-characterized. While tumor-associated neutrophils (TANs) were initially reg…
View article: CSIG-10. ROLE OF c-Met/β1 INTEGRIN COMPLEX IN THE ESTABLISHMENT OF BRAIN METASTASES
CSIG-10. ROLE OF c-Met/β1 INTEGRIN COMPLEX IN THE ESTABLISHMENT OF BRAIN METASTASES Open
INTRODUCTION Metastases cause 90% of human cancer deaths. The metastatic cascade involves five steps: invasion, intravasation, extravasation, colonization, and proliferation. While individual mediators of these processes have been investig…
View article: Management of Noncatastrophic Internal Carotid Artery Injury in Endoscopic Skull Base Surgery
Management of Noncatastrophic Internal Carotid Artery Injury in Endoscopic Skull Base Surgery Open
Arterial injuries are the most feared complication of endoscopic skull base surgery. During resection of the middle fossa component of a large ventral skull base chondrosarcoma, arterial bleeding was encountered near the right internal car…
View article: CADD-31. CD97 PERTUBATION BY NOVEL FUSION PROTEIN DAF-FC INHIBITS GBM INVASION AND INDUCES ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY
CADD-31. CD97 PERTUBATION BY NOVEL FUSION PROTEIN DAF-FC INHIBITS GBM INVASION AND INDUCES ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY Open
INTRODUCTION: The poor prognosis of GBM reflects its capacity to supplement proliferative programs with pro-tumoral interactions with the microenvironment, including invasion and immunosuppression. There is a need to simultaneously target …
View article: EXTH-04. TARGETING CD97 BY NOVEL FUSION PROTEIN DAF-FC INHIBITS GBM INVASION AND INDUCES ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY
EXTH-04. TARGETING CD97 BY NOVEL FUSION PROTEIN DAF-FC INHIBITS GBM INVASION AND INDUCES ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY Open
INTRODUCTION: The poor prognosis of GBM reflects its capacity to supplement proliferative programs with pro-tumoral interactions with the microenvironment, including invasion and immunosuppression. There is a need to simultaneously target …