Michael W. Salter
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View article: Protein-protein interaction interfering peptide rescues dysregulated NMDA receptor signaling
Protein-protein interaction interfering peptide rescues dysregulated NMDA receptor signaling Open
The complex and heterogeneous genetic architecture of neuropsychiatric illnesses compels us to look beyond individual risk genes for therapeutic strategies and target the interactive dynamics and convergence of their protein products. A me…
View article: Meningeal macrophages mask incision pain sensitization in male rats
Meningeal macrophages mask incision pain sensitization in male rats Open
Introduction: Meninges surrounding the brain and spinal cord house a variety of immune cell types including macrophages that express the CD206 mannose receptor. Here, we investigated whether CD206 + macrophages in the meninges play a role …
View article: Meningeal macrophages mask incision pain sensitization in male rats
Meningeal macrophages mask incision pain sensitization in male rats Open
Introduction: Meninges surrounding the brain and spinal cord house a variety of immune cell types including macrophages that express the CD206 mannose receptor. Here, we investigated whether CD206 + macrophages in the meninges play a role …
View article: N1 cassette-lacking NMDA receptors mediate the antidepressant activity of ketamine
N1 cassette-lacking NMDA receptors mediate the antidepressant activity of ketamine Open
Summary Ketamine has emerged as a rapid-acting and robust antidepressant 1,2 . However, the mechanism of its antidepressant action remains enigmatic. The core issue that has yet to be resolved is whether NMDA receptors (NMDARs), which are …
View article: Assigning Targetable Molecular Pathways to Transdiagnostic Subgroups Across Autism and Related Neurodevelopmental Disorders
Assigning Targetable Molecular Pathways to Transdiagnostic Subgroups Across Autism and Related Neurodevelopmental Disorders Open
Significant genetic, behavioural and neuroanatomic heterogeneity is common in autism spectrum- and related- neurodevelopmental disorders (NDDs). This heterogeneity constrains the development of effective therapies for diverse patients in p…
View article: An X-linked long non-coding RNA, PTCHD1-AS, regulates autistic behaviors in humans and in mice
An X-linked long non-coding RNA, PTCHD1-AS, regulates autistic behaviors in humans and in mice Open
There are ~100 genes or copy number variants (CNVs) used in genetic testing for Autism Spectrum Disorder (ASD, or autism). These genes are protein-coding, and the associated phenotypes often extend beyond socio-behavioral traits seen in au…
View article: Neural crest precursors from the skin are the primary source of directly reprogrammed neurons
Neural crest precursors from the skin are the primary source of directly reprogrammed neurons Open
View article: NINJ1 is activated by calcium-driven plasma membrane lipid scrambling during lytic cell death
NINJ1 is activated by calcium-driven plasma membrane lipid scrambling during lytic cell death Open
NINJ1 is the terminal executioner of cellular rupture in multiple lytic cell death pathways through its clustering in the plasma membrane. Its activation trigger, however, remains unknown. We found that NINJ1-mediated plasma membrane ruptu…
View article: An <i>Irak1-Mecp2</i> tandem duplication mouse model for the study of <i>MECP2</i> duplication syndrome
An <i>Irak1-Mecp2</i> tandem duplication mouse model for the study of <i>MECP2</i> duplication syndrome Open
MECP2 duplication syndrome (MDS) is a neurodevelopmental disorder caused by tandem duplication of the MECP2 locus and its surrounding genes, including IRAK1. Current MDS mouse models involve transgenic expression of MECP2 only, limiting th…
View article: Src dependency of the regulation of LTP by alternative splicing of <i>GRIN1</i> exon 5
Src dependency of the regulation of LTP by alternative splicing of <i>GRIN1</i> exon 5 Open
Alternative splicing of Grin1 exon 5 regulates induction of long-term potentiation (LTP) at Schaffer collateral-CA1 synapses: LTP in mice lacking the GluN1 exon 5-encoded N1 cassette (GluN1a mice) is significantly increased compared with t…
View article: Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females
Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females Open
Chronic pain is associated with alterations in fundamental cellular processes. Here, we investigate whether Beclin 1, a protein essential for initiating the cellular process of autophagy, is involved in pain processing and is targetable fo…
View article: Knockout of Dectin-1 does not modify disease onset or progression in a MATR3 S85C knock-in mouse model of ALS
Knockout of Dectin-1 does not modify disease onset or progression in a MATR3 S85C knock-in mouse model of ALS Open
Microglia have been increasingly implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Dectin-1, encoded by the Clec7a gene, is highly upregulated in a specific microglial response state called disease-as…
View article: Blocking Src-PSD-95 interaction rescues glutamatergic signaling dysregulation in schizophrenia
Blocking Src-PSD-95 interaction rescues glutamatergic signaling dysregulation in schizophrenia Open
The complex and heterogeneous genetic architecture of schizophrenia inspires us to look beyond individual risk genes for therapeutic strategies and target their interactive dynamics and convergence. Postsynaptic NMDA receptor (NMDAR) compl…
View article: Calcium-Dependent Hyperexcitability in Human Stem Cell–Derived Rett Syndrome Neuronal Networks
Calcium-Dependent Hyperexcitability in Human Stem Cell–Derived Rett Syndrome Neuronal Networks Open
View article: Hyperexcitability in human<i>MECP2</i>null neuronal networks manifests as calcium-dependent reverberating super bursts
Hyperexcitability in human<i>MECP2</i>null neuronal networks manifests as calcium-dependent reverberating super bursts Open
Rett syndrome (RTT) patients show abnormal developmental trajectories including loss of language and repetitive hand movements but also have signs of cortical hyperexcitability such as seizures. RTT is predominantly caused by mutations in …
View article: Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I
Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I Open
The unitary postsynaptic response to presynaptic quantal glutamate release is the fundamental basis of excitatory information transfer between neurons. The view, however, of individual glutamatergic synaptic connections in a population as …
View article: Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females
Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females Open
Chronic pain is a pervasive health, social, and economic problem affecting 1 in 5 individuals around the world. Increasingly, it is understood that alterations in fundamental cell biological processes are critical for chronic pain. A promi…
View article: Growth of p-type GaN – The role of oxygen in activation of Mg-doping
Growth of p-type GaN – The role of oxygen in activation of Mg-doping Open
View article: Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I
Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I Open
The unitary postsynaptic response to presynaptic quantal glutamate release is the fundamental basis of excitatory information transfer between neurons. The view, however, of individual glutamatergic synaptic connections in a population as …
View article: A Cas9-fusion proximity-based approach generates an<i>Irak1-Mecp2</i>tandem duplication mouse model for the study of MeCP2 duplication syndrome
A Cas9-fusion proximity-based approach generates an<i>Irak1-Mecp2</i>tandem duplication mouse model for the study of MeCP2 duplication syndrome Open
MECP2 duplication syndrome (MDS) is a neurodevelopmental disorder caused by tandem duplication of the MECP2 locus and its surrounding genes, including IRAK1 . Current MDS mouse models involve transgenic expression of MECP2 only, limiting t…
View article: Regulation of neuropathic pain by microglial Orai1 channels
Regulation of neuropathic pain by microglial Orai1 channels Open
Microglia are important mediators of neuroinflammation, which underlies neuropathic pain. However, the molecular checkpoints controlling microglial reactivity are not well-understood. Here, we investigated the role of Orai1 channels for mi…
View article: Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem
Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem Open
The study of chronic pain continues to generate ever-increasing numbers of publications, but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex-specific mechanisms underlying chronic pain has resulted in a …
View article: Microglia states and nomenclature: A field at its crossroads
Microglia states and nomenclature: A field at its crossroads Open
View article: Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations
Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations Open
Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by heterozygous loss-of-function mutations in the X-linked gene MECP2 that is a global transcriptional regulator. Mutations in the methyl-CpG binding domain (MBD)…
View article: Regulation of neuropathic pain by microglial Orai1 channels
Regulation of neuropathic pain by microglial Orai1 channels Open
Microglia are important mediators of neuroinflammation that underlies neuropathic pain. However, the molecular checkpoints controlling microglial reactivity are not well-understood. We investigated the role of Orai1 channels for microglia-…
View article: Targeting NMDA receptors in neuropsychiatric disorders by drug screening on human neurons derived from pluripotent stem cells
Targeting NMDA receptors in neuropsychiatric disorders by drug screening on human neurons derived from pluripotent stem cells Open
View article: Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain
Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain Open
Chronic pain is a devastating problem affecting 1 in 5 individuals around the globe, with neuropathic pain the most debilitating and poorly treated type of chronic pain. Advances in transcriptomics and data mining have contributed to catal…
View article: Methacrylic acid-based biomaterials promote peripheral innervation in the subcutaneous space of mice
Methacrylic acid-based biomaterials promote peripheral innervation in the subcutaneous space of mice Open
Peripheral nerve innervation is essential for regulating tissue repair and regeneration. MAA-based biomaterials have been previously shown to promote angiogenesis. Here we show a new role for MAA-based biomaterials in promoting terminal ax…
View article: Microglia-independent peripheral neuropathic pain in male and female mice
Microglia-independent peripheral neuropathic pain in male and female mice Open
The dominant view in the field of pain is that peripheral neuropathic pain is driven by microglia in the somatosensory processing region of the spinal dorsal horn. Here, to the contrary, we discovered a form of neuropathic pain that is ind…
View article: Glial-modulating agents for the treatment of pain: protocol for a systematic review
Glial-modulating agents for the treatment of pain: protocol for a systematic review Open
Introduction Evidence suggests a role for Central nervous system glia in pain transmission and in augmenting maladaptive opioid effects. Identification of drugs that modulate glia has guided the evaluation of glial suppression as a pain ma…