Michael Schumm
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View article: Graft Manipulation
Graft Manipulation Open
Graft manipulation is performed to define and to optimize the volume and cellular composition of stem cell sources like apheresis products, bone marrow, or umbilical cord blood.
View article: Automated production of specific T cells for treatment of refractory viral infections after allogeneic stem cell transplantation
Automated production of specific T cells for treatment of refractory viral infections after allogeneic stem cell transplantation Open
Therapy-resistant viral reactivations contribute significantly to mortality after hematopoietic stem cell transplantation. Adoptive cellular therapy with virus-specific T cells (VST) has shown efficacy in various single-center trials. Howe…
View article: Invariant NKT Cells From Donor Lymphocyte Infusions (DLI-iNKTs) Promote ex vivo Lysis of Leukemic Blasts in a CD1d-Dependent Manner
Invariant NKT Cells From Donor Lymphocyte Infusions (DLI-iNKTs) Promote ex vivo Lysis of Leukemic Blasts in a CD1d-Dependent Manner Open
Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative treatment option for hematologic malignancies but relapse remains the most common cause of death. Infusion of donor lymphocytes (DLIs) can induce remission and prolong …
View article: G‐CSF administration prior to donor lymphocyte apheresis promotes anti‐leukaemic effects in allogeneic HCT patients
G‐CSF administration prior to donor lymphocyte apheresis promotes anti‐leukaemic effects in allogeneic HCT patients Open
Summary Donor lymphocyte infusion (DLI) is an effective method to establish full donor chimerism or to prevent and treat relapse after allogeneic haematopoietic cell transplantation (allo‐HCT). Usually, DLIs are collected from naïve donors…
View article: Graft Manipulation
Graft Manipulation Open
Graft manipulation is performed to define and to optimize the volume and cellular composition of stem cell sources like apheresis products, bone marrow, or umbilical cord blood.
View article: Haploidentical Stem Cell Transplantation for Refractory/Relapsed Neuroblastoma
Haploidentical Stem Cell Transplantation for Refractory/Relapsed Neuroblastoma Open
Pediatric patients with refractory or relapsed metastatic neuroblastoma (NBL) have a poor prognosis despite autologous stem cell transplantation (SCT). Allogeneic SCT from a haploidentical donor has a remarkable alloreactive effect in pati…
View article: CD34<sup>+</sup> selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation
CD34<sup>+</sup> selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation Open
Summary Poor graft function ( PGF ) is a severe complication of haematopoietic stem cell transplantation ( HSCT ) and administration of donor stem cell boosts ( SCB s) represents a therapeutic option. We report 50 paediatric patients with …
View article: Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study
Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study Open
Background . Calcineurin inhibitors (CNI) have significantly improved patient and graft survival in pediatric liver transplantation (pLT). However, CNI toxicity leads to significant morbidity. Moreover, CNIs cannot prevent long-term allogr…
View article: Treatment of graft failure with <scp>TNI</scp>‐based reconditioning and haploidentical stem cells in paediatric patients
Treatment of graft failure with <span>TNI</span>‐based reconditioning and haploidentical stem cells in paediatric patients Open
Summary Graft failure is a life‐threatening complication after allogeneic haematopoietic stem cell transplantation ( HSCT ). We report a cohort of 19 consecutive patients (median age: 8·5 years) with acute leukaemias ( n = 14) and non‐mali…
View article: Transplantation of Haploidentical CD3/CD19 Depleted Stem Cells in Children: Final Results of a Multicenter Phase I/II Study
Transplantation of Haploidentical CD3/CD19 Depleted Stem Cells in Children: Final Results of a Multicenter Phase I/II Study Open
A total of 163 pediatric patients with ALL, AML/MDS, CML/JMML (n=67) relapsed/refractory solid tumors (neuroblastoma, soft tissue sarcomas, n=68) and nonmalignant diseases (immune deficiencies, hemoglobinopathies) (n=28) received T and B c…