Michael Seen
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Metabolic medications modify prostate cancer progression through exosome reprogramming Open
Among prostate cancer patients, co-morbid Type 2 Diabetes (T2D) is associated with faster progression to biochemical recurrence and increased risk of mortality. Previous work from our lab provides evidence that exosomes purified from media…
View article: T2D-associated exosomes induce ER stress and metabolic reprogramming in tumor CD8+ T cells 9231
T2D-associated exosomes induce ER stress and metabolic reprogramming in tumor CD8+ T cells 9231 Open
Description Tumor-infiltrating lymphocytes (TILs) are critical for anti-tumor immunity but are frequently impaired in the tumor microenvironment (TME). Immunotherapies aimed at reversing this dysfunction often fail, particularly in women w…
Plasma exosomes in insulin resistant obesity exacerbate progression of triple negative breast cancer Open
Breast cancer, the most common cancer among women worldwide, continues to pose significant public health challenges. Among the subtypes of breast cancer, triple-negative breast cancer (TNBC) is particularly aggressive and difficult to trea…
Supplementary Figure 4 from Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes Open
Figure S4 shows pathway enrichment analysis using genesets that are highly expressed in IS group vs IR group and highly expressed in IS group vs Control
Data from Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes Open
Patients with triple-negative breast cancer (TNBC) and comorbid type 2 diabetes (T2D), characterized by insulin resistance of adipose tissue, have a higher risk of metastasis and shorter survival. Adipocytes are the main nonmalignant cells…
Supplementary Figure 2 from Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes Open
Figure S2 shows ki67 expression in liver and RNA sequencing data from primary tumor from 4T1 tumor bearing mouse
Supplementary Figure 3 from Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes Open
Figure S3 shows clonogenic assay from lung
Supplementary Figure 1 from Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes Open
Figure S1 shows characterization of exosome and heatmaps of gene expression in 4T1 cells
Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes Open
Patients with triple-negative breast cancer (TNBC) and comorbid type 2 diabetes (T2D), characterized by insulin resistance of adipose tissue, have a higher risk of metastasis and shorter survival. Adipocytes are the main nonmalignant cells…
Plasma Exosomes in Insulin Resistant Obesity Exacerbate Progression of Triple Negative Breast Cancer Open
Breast cancer, the most common cancer among women worldwide, continues to pose significant public health challenges. Among the subtypes of breast cancer, triple-negative breast cancer (TNBC) is particularly aggressive and difficult to trea…
Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids Open
Women with obesity-driven diabetes (T2D) are predisposed to more aggressive breast cancers, yet patient metabolic status does not fully inform current standards of care. We previously identified plasma exosomes as key mediators of intercel…
Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes Open
Patients with triple negative breast cancer (TNBC) and comorbid Type 2 Diabetes (T2D), characterized by insulin resistance of adipose tissue, have higher risk of metastasis and shorter survival. Adipocytes are the main non-malignant cells …