Mary C. Sheehan
YOU?
Author Swipe
View article: Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis
Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis Open
Background The immunosuppressive tumour microenvironment (TME) reduces immune response effectiveness in stromal-rich tumours, including CMS4 colorectal cancer (CRC). Mesenchymal stromal cells (MSCs), precursors to cancer-associated fibrobl…
View article: Tumor-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signaling
Tumor-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signaling Open
CMS4 colorectal cancer (CRC), based on the consensus molecular subtype (CMS), stratifies patients with the poorest disease-free survival rates. It is characterized by a strong mesenchymal stromal cell (MSC) signature, wound healing-like in…
View article: Perforated small bowel lymphoma presenting as an acute abdomen and requiring emergency surgery, a case report
Perforated small bowel lymphoma presenting as an acute abdomen and requiring emergency surgery, a case report Open
Introduction: Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma (NHL). It accounts for most lymphomas affecting the gastrointestinal (GI) tract. Extranodal sites include the stomach, small intestine, a…
View article: Offence trajectories of young Australian novice drivers
Offence trajectories of young Australian novice drivers Open
This paper aims to add to the sparse research on patterns of traffic offending in young novice drivers by examining the trajectories of young Australian novices throughout the graduated driving licensing system (GDLS). Data on licensing, c…
View article: 967 Inflammatory tumour microenvironment in CRC alters macrophage function through mesenchymal stromal cell PD-1/PD-L1 signalling
967 Inflammatory tumour microenvironment in CRC alters macrophage function through mesenchymal stromal cell PD-1/PD-L1 signalling Open
Background Colorectal cancer (CRC) is the 3rd leading cause of cancer related deaths worldwide despite recent improvement in treatment options. CRC patients with mesenchymal stromal cell (MSC) rich tumours (CMS4 subtype) have the lowest su…
View article: Patients’ Preferences for Adjunctive Parkinson’s Disease Treatments: A Discrete-Choice Experiment
Patients’ Preferences for Adjunctive Parkinson’s Disease Treatments: A Discrete-Choice Experiment Open
BACKGROUND: Several adjunctive medications are available to reduce OFF time between levodopa/carbidopa (LD/CD) doses for people with Parkinson’s disease (PD). OBJECTIVE: To explore how individuals with PD balance benefits and burdens when …
View article: Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment
Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment Open
Immunosuppressive tumor microenvironments (TMEs) reduce the effectiveness of immune responses in cancer. Mesenchymal stromal cells (MSCs), precursors to cancer-associated fibroblasts (CAFs), promote tumor progression by enhancing immune ce…
View article: Use of Bayesian decision analysis to maximize value in patient-centered randomized clinical trials in Parkinson’s disease
Use of Bayesian decision analysis to maximize value in patient-centered randomized clinical trials in Parkinson’s disease Open
A fixed one-sided significance level of 5% is commonly used to interpret the statistical significance of randomized clinical trial (RCT) outcomes. While it is necessary to reduce the false positive rate, the threshold used could be chosen …
View article: Including People with Parkinson’s Disease in Clinical Study Design and Execution: A Call to Action
Including People with Parkinson’s Disease in Clinical Study Design and Execution: A Call to Action Open
The proactive inclusion of patients in the design and execution of clinical studies has been an emerging focus for decades. Such participatory research helps to design studies better, by addressing relevant research questions and defining …
View article: Schwannoma of the Appendix Orifice
Schwannoma of the Appendix Orifice Open
Schwannomas are rare mesenchymal tumors. They are usually diagnosed incidentally during endoscopic or diagnostic imaging for another reason. Malignant transformation is rare. In this case report, we present an incidental schwannoma protrud…
View article: Taking Care of Friends: The Implementation Evaluation of a Peer-Focused School Program Using First Aid to Reduce Adolescent Risk-Taking and Injury
Taking Care of Friends: The Implementation Evaluation of a Peer-Focused School Program Using First Aid to Reduce Adolescent Risk-Taking and Injury Open
Injury is a leading cause of adolescent deaths, with risk-taking associated with a sizeable proportion of injuries and many of those risks undertaken in the presence of peers or with peers’ knowledge. Novel ways to promote safety are requi…
View article: Stromal cell sialylation suppresses T cells in inflammatory tumour microenvironments: A new tumour stromal cell immune checkpoint?
Stromal cell sialylation suppresses T cells in inflammatory tumour microenvironments: A new tumour stromal cell immune checkpoint? Open
Immunosuppressive tumour microenvironments (TME) reduce the effectiveness of immune responses in cancer. Non-haematopoietic mesenchymal stromal cells (MSC), the precursor to cancer associated fibroblasts (CAFs), dictate tumour progression …
View article: Parkinson’s Patients’ Tolerance for Risk and Willingness to Wait for Potential Benefits of Novel Neurostimulation Devices: A Patient-Centered Threshold Technique Study
Parkinson’s Patients’ Tolerance for Risk and Willingness to Wait for Potential Benefits of Novel Neurostimulation Devices: A Patient-Centered Threshold Technique Study Open
Background. Parkinson’s disease (PD) is neurodegenerative, causing motor, cognitive, psychological, somatic, and autonomic symptoms. Understanding PD patients’ preferences for novel neurostimulation devices may help ensure that devices are…
View article: Patient-Centered Identification of Meaningful Regulatory Endpoints for Medical Devices to Treat Parkinson’s Disease
Patient-Centered Identification of Meaningful Regulatory Endpoints for Medical Devices to Treat Parkinson’s Disease Open
Introduction. A growing literature has developed on identifying outcomes that matter to patients. This study demonstrates an approach involving patient and regulatory perspectives to identify outcomes that are meaningful in the context of …
View article: 865 Sugar high: Does the sialic acid profile of cancer-associated fibroblasts induce a more tumour-permissive microenvironment?
865 Sugar high: Does the sialic acid profile of cancer-associated fibroblasts induce a more tumour-permissive microenvironment? Open
Background Immunosuppressive tumour microenvironments (TME) inhibit the effectiveness of cancer immunotherapies. Sialic acids, which exist as terminal sugars of glyco-conjugates, are highly expressed on cancer cells and are involved in var…
View article: What is the cause of this sigmoid stricture in this 43yr old lady with a 3 year history of cyclical lower abdominal pain?
What is the cause of this sigmoid stricture in this 43yr old lady with a 3 year history of cyclical lower abdominal pain? Open
CT Colonography was performed after difficulty passing the stricture at colonoscopy. On imaging, the stricture was concerning for neoplasm (Fig 1). The patient underwent a segmental colectomy with histological analysis of the stricture dem…
View article: Understanding the Roles of Remoteness and Indigenous Status in Rural and Remote Road Trauma in North Queensland: Using a Mixed-Methods Approach
Understanding the Roles of Remoteness and Indigenous Status in Rural and Remote Road Trauma in North Queensland: Using a Mixed-Methods Approach Open
Road trauma is a significant health problem in rural and remote regions of Australia, particularly for Indigenous communities. This study aims to identify and compare the circumstances leading to (proximal causation) and social determinant…
View article: Neoadjuvant radiotherapy for rectal cancer management
Neoadjuvant radiotherapy for rectal cancer management Open
Thirty per cent of all colorectal tumours develop in the rectum. The location of the rectum within the bony pelvis and its proximity to vital structures presents significant therapeutic challenges when considering neoadjuvant options and s…
View article: Structural Design of a Geodesic-inspired Structure for Oculus: Solar Decathlon Africa 2019
Structural Design of a Geodesic-inspired Structure for Oculus: Solar Decathlon Africa 2019 Open
The goal of this project was to create the structural design for a lightweight dome frame structure for the 2019 Solar Decathlon Africa competition in Morocco. The design consisted of developing member sizes and joint connections using bot…
View article: Melena as an unusual presentation of gastrointestinal stromal tumour, a case report
Melena as an unusual presentation of gastrointestinal stromal tumour, a case report Open
We conclude that GIST should be considered as a possible differential in rare cases of GI bleeding where more common causes have been ruled out.
View article: Development and Validation of a Cross-National Measure of High Performance Work Practices
Development and Validation of a Cross-National Measure of High Performance Work Practices Open
This study provides empirical support for a seven-factor multi-item measure of High Performance Work practices using data from multiple managers working for companies in 18 different countries (N = 3,289). Reliability, generalizability, me…
View article: School‐Based First Aid Training Programs: A Systematic Review
School‐Based First Aid Training Programs: A Systematic Review Open
BACKGROUND This review examines the breadth of first aid training delivered to school students and the components that are age appropriate to adolescents. METHOD Eligible studies included school‐based first aid interventions targeting stud…
View article: Knowledge and behaviors of drunk-driving offenders in Guangzhou, China
Knowledge and behaviors of drunk-driving offenders in Guangzhou, China Open
Jia, K., Fleiter, J., King, M., Sheehan, M., Ma, W., & Zhang, J. (2015). Knowledge and behaviors of drunk-driving offenders in Guangzhou, China. The International Journal Of Alcohol And Drug Research, 4(2), 151-158. doi:http://dx.doi.org/1…
View article: Knowledge and behaviors of drunk-driving offenders in Guangzhou, China
Knowledge and behaviors of drunk-driving offenders in Guangzhou, China Open
Jia, K., Fleiter, J., King, M., Sheehan, M., Ma, W., & Zhang, J. (2015). Knowledge and behaviors of drunk-driving offenders in Guangzhou, China. The International Journal Of Alcohol And Drug Research, 4(2), 151-158. doi:http://dx.doi.org/1…
View article: Drink driver rehabilitation and new developments
Drink driver rehabilitation and new developments Open
Drink driving continues to be a major public health concern. Significant reductions in road fatalities have been achieved due largely to the Safe Systems Approach to road safety. However, serious injury due to road trauma has increased in …
View article: Implementing best practice principles in the delivery of a learner driver mentor program in rural Queensland: a case study report
Implementing best practice principles in the delivery of a learner driver mentor program in rural Queensland: a case study report Open
Learner Driver Mentor Programs (LDMPs) assist disadvantaged learner drivers to gain supervised on-road driving experience by providing access to vehicles and volunteer mentors. In the absence of existing research investigating the implemen…
View article: General Motor Vehicle Drivers’ Knowledge and Practices Regarding Drink Driving in Yinchuan and Guangzhou, China
General Motor Vehicle Drivers’ Knowledge and Practices Regarding Drink Driving in Yinchuan and Guangzhou, China Open
Objective: Drink driving contributes to significant levels of injury and economic loss in China but is not well researched. This study examined knowledge, drink-driving practices, and alcohol misuse problems among general drivers in Yinchu…