Sheldon M. Singh
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View article: Echocardiographic estimation of left atrial pressure - validation of an old standard
Echocardiographic estimation of left atrial pressure - validation of an old standard Open
Background Evaluation of left atrial pressure (LAP) is essential for effective management of cardiovascular disease. Current techniques do not provide an easy method of LAP measurement. Pulmonary capillary wedge pressure (PCWP) is used as …
View article: Association of Albuminuria With 1‐Year Risk of Heart Failure and Other Adverse Outcomes in Atrial Fibrillation
Association of Albuminuria With 1‐Year Risk of Heart Failure and Other Adverse Outcomes in Atrial Fibrillation Open
Background Albuminuria is associated with increased stroke risk in atrial fibrillation (AF), but its relationship with heart failure (HF) and other adverse outcomes in AF is less well understood. Methods Using linked administrative databas…
View article: Left atrial deceleration outperforms regional conduction velocity in predicting arrhythmia recurrence following atrial fibrillation ablation
Left atrial deceleration outperforms regional conduction velocity in predicting arrhythmia recurrence following atrial fibrillation ablation Open
TD is a novel metric for quantifying LA remodeling and predicting AA recurrence post-PVI that outperforms CVmin. This may guide future trials focusing on improving success from substrate-based AF ablation.
View article: Factors Associated with Same-Day Discharge After Catheter Ablation Procedures for Supraventricular Tachycardia in Ontario, Canada
Factors Associated with Same-Day Discharge After Catheter Ablation Procedures for Supraventricular Tachycardia in Ontario, Canada Open
Variation in SDD after SVT ablation procedures is primarily related to hospital factors. Policymakers are encouraged to explore hospital-level barriers to adopting this approach.
View article: The Evolution of Head-Upright Tilt-Table Testing in Toronto, Ontario, Canada: 2014-2024
The Evolution of Head-Upright Tilt-Table Testing in Toronto, Ontario, Canada: 2014-2024 Open
The real-world use of head-upright tilt-table tests (HUTTs) in North America is not known. This single-centre retrospective study in Toronto, Ontario, Canada reports on 1063 HUTTs conducted between 2014 and 2024. Use of the HUTT increased …
View article: Myocardial Infarction With No Obstructive Coronary Artery Disease and the 2023 Turkiye Earthquakes
Myocardial Infarction With No Obstructive Coronary Artery Disease and the 2023 Turkiye Earthquakes Open
Background Increased rates of cardiac events at the time of natural disasters have been reported. However, the relationship between myocardial infarctions and earthquakes is less clear. We report on the rate of myocardial infarction with n…
View article: Failure of Ventricular Fibrillation Sensing During Subcutaneous Implantable Defibrillator Testing: A Twitchy Situation
Failure of Ventricular Fibrillation Sensing During Subcutaneous Implantable Defibrillator Testing: A Twitchy Situation Open
Oversensing of extra-cardiac noise may inhibit delivery of subcutaneous cardiac implantable defibrillator (S-ICD) therapy. We report a case of diaphragmatic tetany resulting in the inhibition of S-ICD therapy at the time of defibrillator t…
View article: Anticoagulation and stroke in hospitalized patients newly diagnosed with secondary atrial fibrillation: a population-based cohort study
Anticoagulation and stroke in hospitalized patients newly diagnosed with secondary atrial fibrillation: a population-based cohort study Open
Background Atrial fibrillation (AF) can be triggered by acute precipitants, with reversion to sinus rhythm after the stressor resolves. This has been described as "secondary AF", to differentiate it from AF without acute provocation ("prim…
View article: “Spasms in Silence”: A case of coronary vasospasm‐induced ventricular fibrillation
“Spasms in Silence”: A case of coronary vasospasm‐induced ventricular fibrillation Open
A 56-year-old man presented following an aborted cardiac arrest. His initial ECGs showed episodes of transient repolarization abnormalities. Coronary vasospasm can be a precipitant for ventricular arrhythmia in these patients, underpinning…
View article: Ablation of ventricular tachycardia after septal myectomy for hypertrophic cardiomyopathy
Ablation of ventricular tachycardia after septal myectomy for hypertrophic cardiomyopathy Open
Electrocardiography and 3D mapping images of the case.
View article: Physical Activity, Heart Rate Variability, and Ventricular Arrhythmia During the COVID-19 Lockdown: Retrospective Cohort Study
Physical Activity, Heart Rate Variability, and Ventricular Arrhythmia During the COVID-19 Lockdown: Retrospective Cohort Study Open
Background Ventricular arrhythmias (VAs) increase with stress and national disasters. Prior research has reported that VA did not increase during the onset of the COVID-19 lockdown in March 2020, and the mechanism for this is unknown. Obje…
View article: Same-Day Discharge After Percutaneous Left Atrial Appendage Occlusion Procedures
Same-Day Discharge After Percutaneous Left Atrial Appendage Occlusion Procedures Open
Information is evolving on the safety of same-day discharge (SDD) after left atrial appendage occlusion (LAAO) procedures. This single-centre retrospective study evaluated the feasibility of SDD and reported on the 30-day rehospitalization…
View article: Stroke risk in women with atrial fibrillation
Stroke risk in women with atrial fibrillation Open
Background and aims Female sex is associated with higher rates of stroke in atrial fibrillation (AF) after adjustment for other CHA2DS2-VASc factors. This study aimed to describe sex differences in age and cardiovascular care to examine th…
View article: High-Power Short-Duration vs Low-Power Long-Duration Ablation for Pulmonary Vein Isolation: A Substudy of the AWARE Randomized Controlled Trial
High-Power Short-Duration vs Low-Power Long-Duration Ablation for Pulmonary Vein Isolation: A Substudy of the AWARE Randomized Controlled Trial Open
Background Pulmonary vein isolations (PVI) are being performed using a high-power, short duration (HPSD) strategy. The purpose of this study was to compare the clinical efficacy and safety outcomes of a HPSD vs low-power long duration (LPL…
View article: Statin Use and Stroke Rate in Older Adults With Atrial Fibrillation: A Population‐Based Cohort Study
Statin Use and Stroke Rate in Older Adults With Atrial Fibrillation: A Population‐Based Cohort Study Open
Background Atherosclerotic disease is an important contributor to adverse outcomes in patients with atrial fibrillation (AF). There is limited recognition of the association between statin use and stroke rates in AF. We aimed to quantify t…
View article: Prognostic Value of Different Thresholds for Myocardial Scar Quantification on Cardiac MRI Late Gadolinium Enhancement Images in Patients Receiving Implantable Cardioverter Defibrillators
Prognostic Value of Different Thresholds for Myocardial Scar Quantification on Cardiac MRI Late Gadolinium Enhancement Images in Patients Receiving Implantable Cardioverter Defibrillators Open
Presence of LGE was associated with a higher rate of appropriate ICD shock or death. Although none of the scar quantification techniques predicted outcomes, the gray zone both in infarct and nonischemic scar was an independent predictor an…
View article: Variation and clinical consequences of wait-times for atrial fibrillation ablation: population level study in Ontario, Canada
Variation and clinical consequences of wait-times for atrial fibrillation ablation: population level study in Ontario, Canada Open
Aims Atrial fibrillation (AF) is the most common cardiac rhythm disorder. Emerging evidence supporting the efficacy of catheter ablation in managing AF has led to increased demand for this therapy, potentially outpacing the capacity to per…
View article: A local activation time histogram—An invaluable tool to diagnose a rare and complex atrial flutter mechanism
A local activation time histogram—An invaluable tool to diagnose a rare and complex atrial flutter mechanism Open
Prior ablation for atrial fibrillation (AF) can predispose patients to the development of atypical atrial flutters, which usually originate from either the left or right atria (LA or RA). Rarely, an atrial flutter circuit can actively invo…