Michael Sieber
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View article: Earlier timing of seasonal respiratory infections and seasonal mortality during the COVID-19 pandemic
Earlier timing of seasonal respiratory infections and seasonal mortality during the COVID-19 pandemic Open
Seasonal respiratory infections typically surge within a limited time window, but the exact timing within a given year is hard to predict. The disruptions caused by the COVID-19 pandemic led to dramatic changes in the transmission dynamics…
View article: Gut-associated functions are favored during microbiome assembly across a major part of <i>C. elegans</i> life
Gut-associated functions are favored during microbiome assembly across a major part of <i>C. elegans</i> life Open
The microbiome expresses a variety of functions that influence host biology. The range of functions depends on the microbiome’s composition, which can change during the host’s lifetime due to neutral assembly processes, host-mediated selec…
View article: Suboptimal environmental conditions prolong phage epidemics in bacterial populations
Suboptimal environmental conditions prolong phage epidemics in bacterial populations Open
Infections by filamentous phages, which are usually nonlethal to the bacterial cells, influence bacterial fitness in various ways. While phage‐encoded accessory genes, for example virulence genes, can be highly beneficial, the production o…
View article: Gut-associated functions are favored during microbiome assembly across<i>C. elegans</i>life
Gut-associated functions are favored during microbiome assembly across<i>C. elegans</i>life Open
The microbiome expresses a variety of functions that influence host biology. The range of functions depends on composition of the microbiome, which itself can change during the lifetime of the host as a consequence of neutral assembly proc…
View article: The microbiome of the marine flatworm Macrostomum lignano provides fitness advantages and exhibits circadian rhythmicity
The microbiome of the marine flatworm Macrostomum lignano provides fitness advantages and exhibits circadian rhythmicity Open
The close association between animals and their associated microbiota is usually beneficial for both partners. Here, we used a simple marine model invertebrate, the flatworm Macrostomum lignano , to characterize the host-microbiota interac…
View article: SUB-OPTIMAL ENVIRONMENTAL CONDITIONS PROLONG PHAGE EPIDEMICS IN BACTERIAL POPULATIONS
SUB-OPTIMAL ENVIRONMENTAL CONDITIONS PROLONG PHAGE EPIDEMICS IN BACTERIAL POPULATIONS Open
Infections by filamentous phages influence bacterial fitness in various ways. While phage-encoded accessory genes, e.g., virulence genes, can be highly beneficial, the production of viral particles is energetically costly and often reduces…
View article: Higher phage virulence accelerates the evolution of host resistance
Higher phage virulence accelerates the evolution of host resistance Open
Pathogens vary strikingly in their virulence and the selection they impose on their hosts. While the evolution of different virulence levels is well studied, the evolution of host resistance in response to different virulence levels is les…
View article: Higher phage virulence accelerates the evolution of host resistance
Higher phage virulence accelerates the evolution of host resistance Open
Pathogens vary strikingly in their virulence and the selection they impose on their hosts. While the evolution of different virulence levels is well studied, the evolution of host resistance in response to different virulence levels is les…
View article: On the effect of inheritance of microbes in commensal microbiomes
On the effect of inheritance of microbes in commensal microbiomes Open
Background Our current view of nature depicts a world where macroorganisms dwell in a landscape full of microbes. Some of these microbes not only transit but establish themselves in or on hosts. Although hosts might be occupied by microbes…
View article: Dynamic proteome allocation regulates the profile of interaction of auxotrophic bacterial consortia
Dynamic proteome allocation regulates the profile of interaction of auxotrophic bacterial consortia Open
Microbial ecosystems are composed of multiple species in constant metabolic exchange. A pervasive interaction in microbial communities is metabolic cross-feeding and occurs when the metabolic burden of producing costly metabolites is distr…
View article: The microbiome of the marine flatworm Macrostomum lignano provides fitness advantages and exhibits circadian rhythmicity
The microbiome of the marine flatworm Macrostomum lignano provides fitness advantages and exhibits circadian rhythmicity Open
The close association between animals and their associated microbiota is usually beneficial for both partners. Here, we used a simple marine model invertebrate, the flatworm Macrostomum lignano, to characterize the host-microbiota interact…
View article: The effect of microbial selection on the occurrence-abundance patterns of microbiomes
The effect of microbial selection on the occurrence-abundance patterns of microbiomes Open
Theoretical models are useful to investigate the drivers of community dynamics. In the simplest case of neutral models, the events of death, birth and immigration of individuals are assumed to only depend on their abundance—thus, all types…
View article: On the effect of inheritance of microbes in commensal microbiomes
On the effect of inheritance of microbes in commensal microbiomes Open
Background Our current view of nature depicts a world where macroorganisms dwell in a landscape full of microbes. Some of these microbes not only transit but establish themselves in or on hosts. Although hosts might be occupied by microbes…
View article: The effect of microbial selection on the occurrence-abundance patterns of microbiomes
The effect of microbial selection on the occurrence-abundance patterns of microbiomes Open
Theoretical models are useful to investigate the drivers of community dynamics. Notable are models that consider the events of death, birth, and immigration of individuals assuming they only depend on their abundance – thus, all types shar…
View article: On the evolutionary origins of host–microbe associations
On the evolutionary origins of host–microbe associations Open
Significance Animals can provide benefits to their associated microbes—and these can, in turn, positively affect their hosts. But how do such mutually beneficial associations arise in the first place? In particular, when animal and microbe…
View article: Stochastic colonization of hosts with a finite lifespan can drive individual host microbes out of equilibrium
Stochastic colonization of hosts with a finite lifespan can drive individual host microbes out of equilibrium Open
Macroorganisms are inhabited by microbial communities that often change through the lifespan of an individual. One of the factors contributing to this change is colonization from the environment. The colonization of initially microbe-free …
View article: Neutrality in the Metaorganism
Neutrality in the Metaorganism Open
Almost all animals and plants are inhabited by diverse communities of microorganisms, the microbiota, thereby forming an integrated entity, the metaorganism. Natural selection should favor hosts that shape the community composition of thes…
View article: Bacteriophage can promote the emergence of physiologically sub-optimal host phenotypes
Bacteriophage can promote the emergence of physiologically sub-optimal host phenotypes Open
Reproduction of bacteria-specific viruses, or bacteriophage, requires the replication and translation machinery of the host cell. As a consequence, phage fitness depends intimately on the physiological state, i.e. growth rate, of the host.…
View article: Functions of the Microbiota for the Physiology of Animal Metaorganisms
Functions of the Microbiota for the Physiology of Animal Metaorganisms Open
Animals are usually regarded as independent entities within their respective environments. However, within an organism, eukaryotes and prokaryotes interact dynamically to form the so-called metaorganism or holobiont, where each partner ful…
View article: Temperate phages as self-replicating weapons in bacterial competition
Temperate phages as self-replicating weapons in bacterial competition Open
Microbial communities are accompanied by a diverse array of viruses. Through infections of abundant microbes, these viruses have the potential to mediate competition within the community, effectively weakening competitive interactions and …
View article: Supplementary material from "Temperate phages as self-replicating weapons in bacterial competition"
Supplementary material from "Temperate phages as self-replicating weapons in bacterial competition" Open
Microbial communities are accompanied by a diverse array of viruses. Through infections of abundant microbes, these viruses have the potential to mediate competition within the community, effectively weakening competitive interactions and …