Michael Soeberdt
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View article: Correction: Fluoxetine exerts anti-proliferative effect in human epidermal keratinocytes
Correction: Fluoxetine exerts anti-proliferative effect in human epidermal keratinocytes Open
View article: Anti-inflammatory and cytoprotective polypharmacology of Canephron N reveals targeting of the IKK-NF-κB and p38-MK2-RIPK1 axes
Anti-inflammatory and cytoprotective polypharmacology of Canephron N reveals targeting of the IKK-NF-κB and p38-MK2-RIPK1 axes Open
Urinary tract infections are among the most frequently occurring forms of infection, and inflammation and tissue damage contribute significantly to symptoms, e.g., dysuria and urge. Canephron N is an orally bioavailable herbal medicine wit…
View article: Fluoxetine exerts anti‐inflammatory effects on human epidermal keratinocytes and suppresses their endothelin release
Fluoxetine exerts anti‐inflammatory effects on human epidermal keratinocytes and suppresses their endothelin release Open
Fluoxetine is a safe antidepressant with remarkable anti‐inflammatory actions; therefore, we aimed to investigate its effects on immortalized (HaCaT) as well as primary human epidermal keratinocytes in a polyinosinic‐polycytidylic acid (p(…
View article: 173 Fluoxetine exerts anti-inflammatory effects on human epidermal keratinocytes, and suppresses their endothelin release
173 Fluoxetine exerts anti-inflammatory effects on human epidermal keratinocytes, and suppresses their endothelin release Open
View article: 622 Fibroblast function in vitro modulated by the melanocortin tripeptide derivatives KdPT and WOL074-029
622 Fibroblast function in vitro modulated by the melanocortin tripeptide derivatives KdPT and WOL074-029 Open
View article: A glycopyrronium bromide 1% cream for topical treatment of primary axillary hyperhidrosis: efficacy and safety results from a phase IIIa randomized controlled trial*
A glycopyrronium bromide 1% cream for topical treatment of primary axillary hyperhidrosis: efficacy and safety results from a phase IIIa randomized controlled trial* Open
GPB 1% cream may provide an effective new treatment option exhibiting a good safety profile for patients with PAHH. The long-term open-label part (phase IIIb) is ongoing.
View article: Can we teach old drugs new tricks?—Repurposing of neuropharmacological drugs for inflammatory skin diseases
Can we teach old drugs new tricks?—Repurposing of neuropharmacological drugs for inflammatory skin diseases Open
Despite the “hype” for monoclonal antibodies, the so‐called biologics, which added significant value to the therapeutic armamentarium of dermatologists and improved the life of many patients, but may exhibit significant adverse effects, th…
View article: Supplementary Material for: Influence of Buffers of Different pH and Composition on the Murine Skin Barrier, Epidermal Proliferation, Differentiation, and Inflammation
Supplementary Material for: Influence of Buffers of Different pH and Composition on the Murine Skin Barrier, Epidermal Proliferation, Differentiation, and Inflammation Open
The pH of the skin is tightly regulated by endogenous buffering systems. We examined the influence of buffers of different pH and composition on skin barrier repair, pH, inflammation, and epidermal thickness/proliferation/differentiation. …
View article: Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake
Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake Open
Significance Suitable chemical tools have been instrumental in the discovery and characterization of the endocannabinoid system. However, the lack of potent and selective inhibitors for endocannabinoid transport has prevented the molecular…
View article: Echinacea purpurea -derived alkylamides exhibit potent anti-inflammatory effects and alleviate clinical symptoms of atopic eczema
Echinacea purpurea -derived alkylamides exhibit potent anti-inflammatory effects and alleviate clinical symptoms of atopic eczema Open
View article: Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity<i>in Vivo</i>
Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity<i>in Vivo</i> Open
In order to develop novel κ agonists restricted to the periphery, a diastereo- and enantioselective synthesis of (4aR,5S,8aS)-configured decahydroquinoxalines 5-8 was developed. Physicochemical and pharmacological properties were fine-tune…
View article: CCDC 1546596: Experimental Crystal Structure Determination
CCDC 1546596: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1546597: Experimental Crystal Structure Determination
CCDC 1546597: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Inhibition of fatty acid amide hydrolase exerts cutaneous anti‐inflammatory effects both <i>in vitro</i> and <i>in vivo</i>
Inhibition of fatty acid amide hydrolase exerts cutaneous anti‐inflammatory effects both <i>in vitro</i> and <i>in vivo</i> Open
Numerous studies introduced epidermal keratinocytes as 'non-classical' immune-competent cells, hence potent primary regulators and active participants of cutaneous immune functions 1, (s1–6). Therefore, targeting them might provide a novel…
View article: CCDC 1485426: Experimental Crystal Structure Determination
CCDC 1485426: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines
Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines Open
View article: CCDC 1051685: Experimental Crystal Structure Determination
CCDC 1051685: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …