Michael E. Stern
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View article: 413 Older Adults Who Refuse Any EMS Assessment Differ From Those Treated and Released Against Medical Advice
413 Older Adults Who Refuse Any EMS Assessment Differ From Those Treated and Released Against Medical Advice Open
View article: Clio: Privacy-Preserving Insights into Real-World AI Use
Clio: Privacy-Preserving Insights into Real-World AI Use Open
How are AI assistants being used in the real world? While model providers in theory have a window into this impact via their users' data, both privacy concerns and practical challenges have made analyzing this data difficult. To address th…
View article: Dicer-2 mutations in Aedes aegypti cells lead to a diminished antiviral function against Rift Valley fever virus and Bunyamwera virus infection
Dicer-2 mutations in Aedes aegypti cells lead to a diminished antiviral function against Rift Valley fever virus and Bunyamwera virus infection Open
Mosquitoes are known to transmit different arthropod-borne viruses belonging to various virus families. The exogenous small interfering RNA pathway plays an important role in the mosquito defence against such virus infections, with Dicer-2…
View article: Insulin eye drops for severe refractory chronic ocular graft-versus-host disease
Insulin eye drops for severe refractory chronic ocular graft-versus-host disease Open
View article: Immunologic basis for development of keratoconjunctivitis sicca in systemic autoimmune diseases: Role of innate immune sensors
Immunologic basis for development of keratoconjunctivitis sicca in systemic autoimmune diseases: Role of innate immune sensors Open
The literature is filled with citations reporting an increased incidence of chronic dry eye disease, also known as keratoconjunctivitis sicca, in patients with systemic autoimmune diseases such as rheumatoid arthritis, Sjögren's Syndrome, …
View article: Initial steps in addressing the challenges of elder mistreatment evaluation: Protocol for evaluating the Vulnerable Elder Protection Team
Initial steps in addressing the challenges of elder mistreatment evaluation: Protocol for evaluating the Vulnerable Elder Protection Team Open
Introduction Although many programmes have been developed to address elder mistreatment, high-quality, rigorous evaluations to assess their impact are lacking. This is partly due to challenges in conducting programme evaluation for such a …
View article: A scoping review of the unassisted physical exam conducted over synchronous audio-video telemedicine
A scoping review of the unassisted physical exam conducted over synchronous audio-video telemedicine Open
View article: Desiccating Stress Significantly Increases the Risk for Chronic Ocular Graft-versus-Host-Disease
Desiccating Stress Significantly Increases the Risk for Chronic Ocular Graft-versus-Host-Disease Open
Desiccating stress (DS) is known to induce dry eye disease but has not been studied in the context of ocular graft-versus-host disease (oGVHD). Patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are exposed …
View article: Vulnerable Elder Protection Team: Initial experience of an emergency d <scp>epartment‐based</scp> interdisciplinary elder abuse program
Vulnerable Elder Protection Team: Initial experience of an emergency d <span>epartment‐based</span> interdisciplinary elder abuse program Open
Background An emergency department (ED) visit provides a unique opportunity to identify elder abuse and initiate intervention, but emergency providers rarely do. To address this, we developed the Vulnerable Elder Protection Team (VEPT), an…
View article: Segmentation and Evaluation of Corneal Nerves and Dendritic Cells From In Vivo Confocal Microscopy Images Using Deep Learning
Segmentation and Evaluation of Corneal Nerves and Dendritic Cells From In Vivo Confocal Microscopy Images Using Deep Learning Open
The deep learning-based automatic segmentation and quantification algorithm significantly increases the efficiency of evaluating IVCM images, thereby supporting and potentially improving the diagnosis and treatment of ocular surface diseas…
View article: Geriatric Burn Injuries Presenting to the Emergency Department of a Major Burn Center: Clinical Characteristics and Outcomes
Geriatric Burn Injuries Presenting to the Emergency Department of a Major Burn Center: Clinical Characteristics and Outcomes Open
View article: Nurse-led sedation for transfemoral transcatheter aortic valve implantation seems safe for a selected patient population
Nurse-led sedation for transfemoral transcatheter aortic valve implantation seems safe for a selected patient population Open
Transcatheter aortic valve implantation (TAVI) has become a high-volume procedure with increasing demands on hospital resources. Local anaesthesia with sedation supervised by an anaesthesiology team is the current standard of care. We aime…
View article: Predicting Unscheduled Emergency Department Revisits Leading to Acute Hospital Admissions Among Older Adults
Predicting Unscheduled Emergency Department Revisits Leading to Acute Hospital Admissions Among Older Adults Open
Background: Unscheduled emergency department (ED) revisits leading to acute hospital admission (RVA) are tantamount to a failed discharge, associated with physician error, mis-prognosis, and inadequate care planning. Previous research has …
View article: Unmet Needs and Social Challenges for Older Adults During and After the COVID-19 Pandemic: An Opportunity to Improve Care
Unmet Needs and Social Challenges for Older Adults During and After the COVID-19 Pandemic: An Opportunity to Improve Care Open
Many older adults have unmet needs and social challenges that can negatively impact their health and well-being, particularly during and after the COVID pandemic. These include social isolation, inadequate care or assistance with their dai…
View article: Adverse Environmental Stress is a Risk Factor for Ocular Graft-Versus-Host Disease
Adverse Environmental Stress is a Risk Factor for Ocular Graft-Versus-Host Disease Open
View article: Efficacy of topical application of cannabinoid receptor ligands in experimental dry eye disease
Efficacy of topical application of cannabinoid receptor ligands in experimental dry eye disease Open
View article: Deep Learning-based Segmentation and Quantification of Nerve Fibers and Dendritic cells in Confocal Microscopy of the Cornea
Deep Learning-based Segmentation and Quantification of Nerve Fibers and Dendritic cells in Confocal Microscopy of the Cornea Open
View article: Ocular Graft-versus-Host Disease in a Chemotherapy-Based Minor-Mismatch Mouse Model Features Corneal (Lymph-) Angiogenesis
Ocular Graft-versus-Host Disease in a Chemotherapy-Based Minor-Mismatch Mouse Model Features Corneal (Lymph-) Angiogenesis Open
Ocular graft-versus-host disease (oGVHD) is a fast progressing, autoimmunological disease following hematopoietic stem cell transplantation, leading to severe inflammation of the eye and destruction of the lacrimal functional unit with con…
View article: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report Open
View article: Deep learning-based automatic meibomian gland segmentation and morphology assessment in infrared meibography
Deep learning-based automatic meibomian gland segmentation and morphology assessment in infrared meibography Open
View article: Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy
Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy Open
Conjunctiva-associated tissue (CALT) is assumed to play a crucial role in the immune system of the ocular surface. Its function in several ocular surface diseases (OSD) is still not fully understood. This study investigates the function of…
View article: Inflammatory basis for dry eye disease flares
Inflammatory basis for dry eye disease flares Open
Most patients with chronic dry eye disease (DED) have episodic flares, which can be triggered by a variety of activities and environmental stresses. These flares are typically associated with rapid exacerbation of discomfort symptoms, foll…
View article: The cornea in keratoconjunctivitis sicca
The cornea in keratoconjunctivitis sicca Open
View article: Chemosensitizing effect of maitake mushroom extract on carmustine cytotoxicity in human bladder cancer cells
Chemosensitizing effect of maitake mushroom extract on carmustine cytotoxicity in human bladder cancer cells Open
Background: Despite several therapeutic options available for bladder cancer, the outcomes are less satisfactory. To find a more effective modality, we were interested in the bioactive mushroom extract, PDF, which has been shown to sensiti…
View article: Detection of systemic immunosuppressants in autologous serum eye drops (ASED) in patients with severe chronic ocular graft versus host disease
Detection of systemic immunosuppressants in autologous serum eye drops (ASED) in patients with severe chronic ocular graft versus host disease Open
Purpose Chronic graft versus host disease is a major consequence after allogeneic stem cell transplantation (allo-SCT) and has great impact on patients’ morbidity and mortality. Besides the skin, liver, and intestines, the eyes are most co…
View article: Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye
Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye Open
Objective: The purpose of this study was to evaluate the potential of voclosporin (VOS) in preventing goblet cell (GC) loss and modulating interferon-gamma (IFN-γ) producing CD4+ T cells in the mouse desiccating st…
View article: Managing Older Adults with Presumed <scp>COVID</scp> ‐19 in the Emergency Department: A Rational Approach to Rationing
Managing Older Adults with Presumed <span>COVID</span> ‐19 in the Emergency Department: A Rational Approach to Rationing Open
The American Geriatric Society's (AGS) position paper on age-related considerations in resource allocation strategies during the COVID-19 era1 and the expanded rationale2 emphasizes the importance of not using age as a categorical exclusio…
View article: Biological functions of tear film
Biological functions of tear film Open
View article: Geriatric Emergency Medicine Fellowships: Current State of Specialized Training for Emergency Physicians in Optimizing Care for Older Adults
Geriatric Emergency Medicine Fellowships: Current State of Specialized Training for Emergency Physicians in Optimizing Care for Older Adults Open
Improving emergency department (ED) care for older adults is a critical issue in emergency medicine. Institutions throughout the United States and Canada have recognized the growing need for a workforce of emergency physician (EP) leaders …
View article: Developing the Emergency Department Elder Mistreatment Assessment Tool for Social Workers Using a Modified Delphi Technique
Developing the Emergency Department Elder Mistreatment Assessment Tool for Social Workers Using a Modified Delphi Technique Open
Elder mistreatment is common and has serious consequences. The emergency department (ED) may provide a unique opportunity to detect this mistreatment, with social workers often asked to take the lead in assessment and intervention. Despite…