Michael Stich
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View article: Fitness Effect of the Isoniazid Resistance Mutation S315T of the Catalase-Peroxidase Enzyme KatG of <i>Mycobacterium tuberculosis</i>
Fitness Effect of the Isoniazid Resistance Mutation S315T of the Catalase-Peroxidase Enzyme KatG of <i>Mycobacterium tuberculosis</i> Open
The mutation S315T of the catalase–peroxidase (CP) protein KatG of Mycobacterium tuberculosis is the most common mutation that confers resistance to the prodrug isoniazid. Here, we reconstruct its evolutionary history in 145 whole-genome s…
View article: A biphasic model of lifespan in nematode <i>Caenorhabditis elegans</i> worm
A biphasic model of lifespan in nematode <i>Caenorhabditis elegans</i> worm Open
Ageing research focuses on identifying lifespan modifiers and understanding and appropriately interpreting their effects. One of the most relevant quantities being studied is the shape of the survival curve that can reveal crucial informat…
View article: Raw fly data RSOS from A biphasic model of lifespan in nematode <i>Caenorhabditis elegans</i> worm
Raw fly data RSOS from A biphasic model of lifespan in nematode <i>Caenorhabditis elegans</i> worm Open
The file contains all raw data pertaining to the fly experiments.
View article: Raw worm data RSOS from A biphasic model of lifespan in nematode <i>Caenorhabditis elegans</i> worm
Raw worm data RSOS from A biphasic model of lifespan in nematode <i>Caenorhabditis elegans</i> worm Open
The file contains all raw data pertaining to the worm experiments.
View article: Reconstruction and validation of entire virus model with complete genome from mixed resolution cryo-EM density
Reconstruction and validation of entire virus model with complete genome from mixed resolution cryo-EM density Open
We, for the first time, reconstruct from the published incomplete cryo-EM density a complete MS2 virus at atomistic resolution, that is, the capsid with the genome, and validate the result by all-atom molecular dynamics with explicit water.
View article: Epidemiological impact of waning immunization on a vaccinated population
Epidemiological impact of waning immunization on a vaccinated population Open
\nThis is an epidemiological SIRV model based study that is designed to analyze the impact of vaccination in containing infection spread, in a 4-tiered population compartment comprised of susceptible, infected, recovered and vaccinated age…
View article: Necessary conditions for the emergence of homochirality <i>via</i> autocatalytic self-replication
Necessary conditions for the emergence of homochirality <i>via</i> autocatalytic self-replication Open
We analyze a recent proposal for spontaneous mirror symmetry breaking based on the coupling of first-order enantioselective autocatalysis and direct production of the enantiomers that invokes a critical role for intrinsic reaction noise. F…
View article: Noise-induced standing waves in oscillatory systems with time-delayed feedback
Noise-induced standing waves in oscillatory systems with time-delayed feedback Open
In oscillatory reaction-diffusion systems, time-delay feedback can lead to the instability of uniform oscillations with respect to formation of standing waves. Here, we investigate how the presence of additive, Gaussian white noise can ind…
View article: Chiral autocatalysis: reaction noise, micro-reversibility and chiral inhibition in mirror symmetry breaking
Chiral autocatalysis: reaction noise, micro-reversibility and chiral inhibition in mirror symmetry breaking Open
Applying the constraints dictated by the principle of detailed balance, we analyze a recent proposal for spontaneous mirror symmetry breaking (SMSB) based on enantioselective autocatalysis coupled to a linear decay of the enantiomers and i…