Michael Strober
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Multivariate Neural Patterns of Reward and Anxiety in Adolescents with Anorexia Nervosa Open
People with anorexia nervosa (AN) commonly exhibit elevated anxiety and atypical reward responsiveness. To examine multivariate neural patterns associated with reward and the impact of anxiety on reward, we analyzed fMRI data from a moneta…
A Risk Calculator to Predict Suicide Attempts Among Individuals With Early-Onset Bipolar Disorder Open
This RC holds promise as a clinical and research tool for prospective identification of individualized high-risk periods for suicide attempt in early-onset bipolar disorder.Reprinted from Bipolar Disord 2022; 24:749-757, with permission fr…
Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach Open
Anorexia nervosa (AN) is characterized by low body weight, fear of gaining weight, and distorted body image. Anxiety may play a role in the formation and course of the illness, especially related to situations involving food, eating, weigh…
View article: A Multi-Modal Assessment of Fear Conditioning in Adolescent Anorexia Nervosa
A Multi-Modal Assessment of Fear Conditioning in Adolescent Anorexia Nervosa Open
Background: Anorexia nervosa (AN) is a pernicious psychiatric disorder which is principally characterized by a fear of weight gain. Notwithstanding the centrality of fear in the psychopathology of AN, controlled assessments of negative val…
Examining Factors Associated With Medication Adherence in Youth With Bipolar Disorder Open
Poor medication adherence is a significant problem in youth with BD with the most influential factor being the presence of comorbid ADHD. Thus, it is important to identify and appropriately treat comorbid ADHD to improve medication adheren…
White matter microstructure in habit and reward circuits in anorexia nervosa: Insights from a neurite orientation dispersion and density imaging study Open
Background Behavioral features of anorexia nervosa (AN) suggest abnormalities in reward and habit. Neuroimaging evidence suggests morphometric and functional perturbations within these circuits, although fewer studies have assessed white m…
White Matter Microstructure in Habit and Reward Circuits in Anorexia Nervosa: Insights from a Neurite Orientation Dispersion and Density Imaging Study Open
Background Behavioural features of anorexia nervosa (AN) suggest abnormalities in reward and habit. Neuroimaging evidence suggests morphometric and functional perturbations within these circuits, although fewer studies have assessed white …
Higher socioeconomic status and less parental psychopathology improve prognosis in youths with bipolar disorder Open
In addition to treating mood/comorbid psychopathology in symptomatic BD youths, to improve their prognosis, it is crucial to address their parent's BD and SUD and promote parental education/employment.
Prospectively ascertained mania and hypomania among young adults with child‐ and adolescent‐onset bipolar disorder Open
Objectives While adults with bipolar disorder (BD) often report symptoms starting in childhood, continuity of mania and/or hypomania (mania/hypomania) from childhood to adulthood has been questioned. Using longitudinal data from the Course…
Longitudinal Associations Between Interpersonal Relationship Functioning and Mood Episode Severity in Youth With Bipolar Disorder Open
This study examined the longitudinal association between mood episode severity and relationships in BP youth. Participants were 413 Course and Outcome of Bipolar Youth study youth, aged 12.6 ± 3.3 years. Monthly ratings of relationships (p…
Sex Differences in the Longitudinal Course and Outcome of Bipolar Disorder in Youth Open
Contrasting with adult literature, this study identified minimal sex differences in the course of youth with BD. Longer-term studies are needed to clarify if youth-onset BD remains a "sex neutral" subtype of BD or diverges according to sex…
A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder Open
Background Youth with bipolar disorder (BD) are at high risk for suicidal thoughts and behaviors and frequently experience interpersonal impairment, which is a risk factor for suicide. Yet, no study to date has examined the longitudinal as…
Neurosurgery and neuromodulation for anorexia nervosa in the 21st century: a systematic review of treatment outcomes Open
As current psychosocial and pharmacological interventions show limited efficacy in the treatment of anorexia nervosa (AN), interest in the potential value of neurosurgical intervention and neuromodulation in managing severe and enduring il…
Speaking of That: Terms to Avoid or Reconsider in the Eating Disorders Field Open
Inspired by an article on 50 terms that, in the interest of clarity in scientific reasoning and communication in psychology, psychiatry, and allied fields, "should be avoided or at most be used sparingly and only with explicit caveats,"(1)…
Correlates, Course, and Outcomes of Increased Energy in Youth with Bipolar Disorder Open
Results indicate no clinically relevant longitudinal group differences.
Cognitive flexibility and performance in children and adolescents with threshold and sub-threshold bipolar disorder Open
Greater understanding of cognitive function in children and adolescents with bipolar disorder (BD) is of critical importance to improve our ability to design targeted treatments to help with real-world impairment, including academic perfor…
Brain activation and connectivity in anorexia nervosa and body dysmorphic disorder when viewing bodies: relationships to clinical symptoms and perception of appearance Open
Anorexia nervosa (AN) and body dysmorphic disorder (BDD) are characterized by distorted perception of appearance, yet no studies have directly compared the neurobiology associated with body perception. We compared brain activation and conn…
Longitudinal course and risk factors associated with psychosis in bipolar youths Open
Objectives To compare the longitudinal clinical course of youths with bipolar disorder (BD) spectrum with lifetime (past, intake, and/or follow‐up) psychosis (BDP+) to youths with BD without lifetime psychosis (BDP−). Also, to identify ris…
High Prevalence of Metabolic Syndrome Among Adolescents and Young Adults With Bipolar Disorder Open
The prevalence of MetS in this sample was at least double compared to the general population. Moreover, MetS is associated with increased burden of depression symptoms in this group. Management of early-onset bipolar disorder should integr…