Explanipedia

The genome sequence of the acalyptrate fly Dryomyza anilis Fallén, 1820 Open

Olga Sivell, Duncan Sivell, Judith A. Webb, Ryan Mitchell, Michael T. Ashworth · 2024

We present a genome assembly from an individual male acalyptrate fly Dryomyza anilis (Arthropoda; Insecta; Diptera; Dryomyzidae). The genome sequence has a total length of 656.60 megabases. Most of the assembly is scaffolded into 7 chromos…

A Proof of Principle 2D Spatial Proteome Mapping Analysis Reveals Distinct Regional Differences in the Cardiac Proteome Open

Wendy Heywood, J.B. Searle, Richard Collis, Ivan Doykov, Michael T. Ashworth , et al. · 2024

Proteomics studies often explore phenotypic differences between whole organs and systems. Within the heart, more subtle variation exists. To date, differences in the underlying proteome are only described between whole cardiac chambers. Th…

The genome sequence of the Figwort Cheilosia, Cheilosia variabilis (Panzer, 1798) Open

Liam M Crowley, Olga Sivell, Michael T. Ashworth, Oliver Poole · 2023

We present a genome assembly from an individual male Cheilosia variabilis (the Figwort Cheilosia; Arthropoda; Insecta; Diptera; Syrphidae). The genome sequence is 414.7 megabases in span. Most of the assembly is scaffolded into 7 chromosom…

The genome sequence of the thick-headed fly, Myopa tessellatipennis (Motschulsky, 1859) Open

Michael T. Ashworth, Steven Falk, David K. Clements · 2023

We present a genome assembly from an individual female Myopa tessellatipennis (Arthropoda; Insecta; Diptera; Conopidae). The genome sequence is 249.3 megabases in span. Most of the assembly is scaffolded into four chromosomal pseudomolecul…

Micro-CT Imaging of Pediatric Thyroglossal Duct Cysts: A Prospective Case Series Open

Claire Frauenfelder, Susan C. Shelmerdine, Ian C. Simcock, Andrew P. Hall, J. Ciaran Hutchinson , et al. · 2021

Objectives: To determine the feasibility of micro-CT as a high-resolution 3D imaging tool for thyroglossal duct cysts and to evaluate its role augmenting traditional histopathological examination of resected specimens. Methods: A single ce…

Preclinical Optimization and Safety Studies of a New Lentiviral Gene Therapy for p47phox-Deficient Chronic Granulomatous Disease Open

Andrea Schejtman, Winston Vetharoy, Uimook Choi, Christine Rivat, Narda Theobald , et al. · 2021

Chronic granulomatous disease (CGD) is an inherited blood disorder of phagocytic cells that renders patients susceptible to infections and inflammation. A recent clinical trial of lentiviral gene therapy for the most frequent form of CGD, …

Postmortem microfocus computed tomography for noninvasive autopsies: experience in >250 human fetuses Open

Susan C. Shelmerdine, Ian C. Simcock, J. Ciaran Hutchinson, Anna Guy, Michael T. Ashworth , et al. · 2020

One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD) Open

Steve Cunningham, Catriona Graham, Morag MacLean, Paul Aurora, Michael T. Ashworth , et al. · 2019

We performed a prospective, observational, cohort study of children newly diagnosed with children’s interstitial lung disease (ChILD), with structured follow-up at 4, 8, 12 weeks and 6 and 12 months. 127 children, median age 0.9 (IQR 0.3–7…

Heart Transplantation Open

Michael T. Ashworth · 2019

Following a brief introduction listing the salient aspects of heart transplantation as they pertain to children, there is a detailed section on assessment of the explanted heart with special reference to cardiomyopathy and congenital heart…

Feasibility of INTACT (INcisionless TArgeted Core Tissue) biopsy procedure for perinatal autopsy Open

Susan C. Shelmerdine, J. Ciaran Hutchinson, L. Ward, Thivya Sekar, Michael T. Ashworth , et al. · 2019

Objectives To determine the feasibility and tissue yield of a perinatal incisionless ultrasound‐guided biopsy procedure, the INcisionless Targeted Core Tissue (INTACT) technique, in the context of minimally invasive autopsy. Methods Cases …

Aspects of paediatric cardiovascular pathology Open

Michael T. Ashworth · 2019

Examination of the malformed heart requires sequential segmental analysis in which the three paired segments of the heart (atria, ventricles, great arteries) are recognized by their most constant feature. Their connections to each other ar…

Micro-CT of tracheal stenosis in trisomy 21 Open

Susan C. Shelmerdine, Michael T. Ashworth, Alistair Calder, Nagarajan Muthialu, Owen J. Arthurs · 2019

A male infant with trisomy 21, born at 36 weeks' gestation, had care withdrawn at 2 months of age and was referred for postmortem investigations. The child had been ventilator dependent since the first week of life following surgery for in…

Minimally invasive perinatal and pediatric autopsy with laparoscopically assisted tissue sampling: feasibility and experience of the MinImAL procedure Open

J. Ciaran Hutchinson, Susan C. Shelmerdine, Celine Lewis, Jessica L. Parmenter, Ian C. Simcock , et al. · 2019

Objective Less invasive autopsy techniques in cases of fetal or infant death have good acceptability among parents, but the published sampling adequacy in needle biopsy studies is generally poor. Minimally Invasive Autopsy with Laparoscopi…

Physiological role of linear ubiquitination: more to it than meets the eye Open

Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Dráber, Helena Draberova , et al. · 2019

Characterization of Bardet–Biedl syndrome by postmortem microfocus computed tomography (micro‐CT) Open

Susan C. Shelmerdine, Mamta Singh, Ian C. Simcock, Alistair Calder, Michael T. Ashworth , et al. · 2018

Confirmation of fetal anomalies detected antenatally is important for informing future management, particularly following termination of pregnancy. Despite significant imaging advances, antenatal ultrasonography identifies only 68% of auto…

Cover Image, Volume 38, Issue 7 Open

Susan C. Shelmerdine, J. Ciaran Hutchinson, Kang Xin, Joseph D. Suich, Michael T. Ashworth , et al. · 2018

Volume rendered three-dimensional image reconstructed from the micro-CT imaging of a 7 week embryo. From Shelmerdine et al., in this issue. https://doi.org/10.1002/pd.5281.

Reappraising myocardial fibrosis in severe aortic stenosis: an invasive and non-invasive study in 133 patients Open

Thomas A. Treibel, Begoña López, Arantxa González, Katia Menacho, Rebecca Schofield , et al. · 2017

Myocardial fibrosis in severe AS is complex, but three main patterns exist: endocardial fibrosis, microscars (mainly in the subendomyocardium), and diffuse interstitial fibrosis. Neither histological CVF nor the CMR parameters ECV and LGE …

Reply Open

Michael T. Ashworth, Alexander Heazell, Neil J. Sebire · 2017

The majority of parents report that investigation of stillbirth is important to obtain information about why their baby died and to inform future care1. Despite this, investigation is frequently incomplete; data from 2014 show that autopsy…

Histiocytoid cardiomyopathy and microphthalmia with linear skin defects syndrome: phenotypes linked by truncating variants in NDUFB11 Open

Gillian Rea, Tessa Homfray, Jan Till, Ferran Rosés‐Noguer, Rachel Buchan , et al. · 2016

Variants in NDUFB11, which encodes a structural component of complex I of the mitochondrial respiratory chain (MRC), were recently independently reported to cause histiocytoid cardiomyopathy (histiocytoid CM) and microphthalmia with linear…

Stillbirth and intrauterine fetal death: role of routine histopathological placental findings to determine cause of death Open

Jessica Man, J. Ciaran Hutchinson, Alexander Heazell, Michael T. Ashworth, Iona Jeffrey , et al. · 2016

Objectives Placental abnormalities are a common cause of death in stillbirth, ranking second only to unexplained deaths, though there is wide variation in the proportion attributed to placental disease. In clinical practice, interpretation…

Stillbirth and intrauterine fetal death: contemporary demographic features of >1000 cases from an urban population Open

Jessica Man, J. Ciaran Hutchinson, Michael T. Ashworth, Alexander Heazell, Iona Jeffrey , et al. · 2016

Objectives Of 780 000 births annually in the UK, around 3300 are stillborn, a rate of approximately 4 per 1000 births. Traditional epidemiological associations are based on historic data. The aim of this study was to document contemporary …

Stillbirth and intrauterine fetal death: factors affecting determination of cause of death at autopsy Open

Jessica Man, J. Ciaran Hutchinson, Alexander Heazell, Michael T. Ashworth, Samantha Levine , et al. · 2016

Objectives There have been several attempts to classify cause of death (CoD) in stillbirth; however, all such systems are subjective, allowing for observer bias and making comparisons between systems challenging. This study aimed to examin…

Stillbirth and intrauterine fetal death: role of routine histological organ sampling to determine cause of death Open

Jessica Man, J. Ciaran Hutchinson, Michael T. Ashworth, Lydia Judge-Kronis, Samantha Levine , et al. · 2016

Objectives Guidelines for the investigation of intrauterine death and sudden unexpected death in infancy ( SUDI ) recommend, based on expert opinion, autopsy procedures and tissue sampling strategies for histological analysis. Although sti…

Issue Information ‐ ToC Open

Hiroaki Samejima, Babiker Sudan, Hajime Takikawa, Minoru Sasaki, Yuya Sugimoto , et al. · 2016

Clinical utility of post-mortem micro-CT of the fetal heart: an exploratory study of diagnostic imaging versus macroscopic dissection Open

J. Ciaran Hutchinson, Owen J. Arthurs, Michael T. Ashworth, Andrew Ramsey, William Mifsud , et al. · 2016

Clinical utility of postmortem microcomputed tomography of the fetal heart: diagnostic imaging vs macroscopic dissection Open

J. Ciaran Hutchinson, Owen J. Arthurs, Michael T. Ashworth, A. T. Ramsey, William Mifsud , et al. · 2015

Objectives Congenital cardiac malformations are commonly identified at perinatal autopsy, which can be challenging in fetuses of early gestation and in macerated fetuses. Our objective was to examine fetal complex congenital heart disease …

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