Michael T. Jaklitsch
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View article: Real-time margin assessment for video-assisted thoracic surgery: A pilot clinical trial
Real-time margin assessment for video-assisted thoracic surgery: A pilot clinical trial Open
Objective: To accurately provide real-time intraoperative guidance on margins despite significant lung deformation. With lung cancer screening programs, smaller, early-stage lung nodules are being detected. Sublobar resection of peripheral…
View article: The current landscape and challenges facing international medical graduates in cardiothoracic surgery training
The current landscape and challenges facing international medical graduates in cardiothoracic surgery training Open
View article: Young lung cancer patients undergoing surgery: Comparison of clinicopathological characteristics and outcomes in patients aged ≤50 years versus >50 years
Young lung cancer patients undergoing surgery: Comparison of clinicopathological characteristics and outcomes in patients aged ≤50 years versus >50 years Open
View article: 542. POST-ESOPHAGECTOMY PARACONDUIT HIATAL HERNIA DEVELOPMENT AND RECURRENCE
542. POST-ESOPHAGECTOMY PARACONDUIT HIATAL HERNIA DEVELOPMENT AND RECURRENCE Open
Background Hiatal hernia post esophagectomy is a delayed postoperative complication. Historically, in open surgery, the incidence is rare. The increased utilization of minimally invasive methods has increased the incidence of hiatal hernia…
View article: Early thoracic surgery consultation and location of therapy impact time to esophagectomy
Early thoracic surgery consultation and location of therapy impact time to esophagectomy Open
Improving access to multispecialty cancer centers and increasing satellite sites may improve time to esophagectomy.
View article: Early adoption of robotic lung resection in an established video assisted thoracic surgery practice
Early adoption of robotic lung resection in an established video assisted thoracic surgery practice Open
The robotic approach facilitates better lymph node sampling, even in an established VATS practice.
View article: The devil is in the details
The devil is in the details Open
Due to the morbidity and mortality associated with pneumonectomy, reducing risk factors for bronchopleural fistula (BPF) development is crucial for the survival of these patients. Our recent publication has revived the discussion amongst s…
View article: Phase II trial of vaccination with autologous, irradiated melanoma cells engineered by adenoviral mediated gene transfer to secrete granulocyte-macrophage colony stimulating factor in patients with stage III and IV melanoma
Phase II trial of vaccination with autologous, irradiated melanoma cells engineered by adenoviral mediated gene transfer to secrete granulocyte-macrophage colony stimulating factor in patients with stage III and IV melanoma Open
Background In the era of immune checkpoint blockade, the role of cancer vaccines in immune priming has provided additional potential for therapeutic improvements. Prior studies have demonstrated delayed type hypersensitivity and anti-tumor…
View article: Esophageal Carcinoma Cuniculatum
Esophageal Carcinoma Cuniculatum Open
Esophageal carcinoma cuniculatum is a rare histology and can be difficult to diagnose prior to resection. To date, there have been 28 cases of resected esophageal carcinoma cuniculatum reported. Herein we describe a case found in the stoma…
View article: Effectiveness of a computer-facilitated intervention on improving provider delivery of tobacco treatment in a thoracic surgery and oncology outpatient setting: A pilot study
Effectiveness of a computer-facilitated intervention on improving provider delivery of tobacco treatment in a thoracic surgery and oncology outpatient setting: A pilot study Open
A computer-facilitated intervention increased provider delivery of tobacco treatment in a thoracic surgery and oncology outpatient setting. This intervention provided a low-resource approach that has the potential to be scaled and implemen…
View article: Secondary Esophageal Cancer After Hematopoietic Stem Cell Transplant: An Institutional Case Series
Secondary Esophageal Cancer After Hematopoietic Stem Cell Transplant: An Institutional Case Series Open
For patients with secondary esophageal cancer, esophagectomy after neoadjuvant treatment has acceptable morbidity and may be a viable option for this cohort.
View article: Multi-institutional beta testing of a novel cervical esophagogastric anastomosis simulator
Multi-institutional beta testing of a novel cervical esophagogastric anastomosis simulator Open
View article: Liposomal bupivacaine intercostal block placed under direct vision reduces morphine use in thoracic surgery
Liposomal bupivacaine intercostal block placed under direct vision reduces morphine use in thoracic surgery Open
Compared to TEA, LB intercostal block placed under direct vision reduced morphine use 48 hours after thoracic surgery. It was also associated with fewer postoperative complications and shorter median hospital LOS. LB is a good alternative …
View article: Lung Cancer in Patients Under 50: What is the Role of Social Determinants of Health?
Lung Cancer in Patients Under 50: What is the Role of Social Determinants of Health? Open
View article: Association of conduit dimensions with perioperative outcomes and long-term quality of life after esophagectomy for malignancy
Association of conduit dimensions with perioperative outcomes and long-term quality of life after esophagectomy for malignancy Open
The dimensions of the gastric conduit and the height of the anastomosis may be independently associated with outcomes and long-term quality of life after esophagectomy for cancer.
View article: Image-guided video-assisted thoracoscopic surgery (iVATS): a single center experience and review
Image-guided video-assisted thoracoscopic surgery (iVATS): a single center experience and review Open
Lung cancer screening techniques using low-dose computed tomography (LDCT) scans have improved over the last decade. This means that there is an increased rate of detection of small, often non-palpable, nodules and ground-glass opacities. …
View article: P1.26-07 Trisegmentectomy is Indicated for Non-Small Cell Lung Cancer in the Left Upper Division
P1.26-07 Trisegmentectomy is Indicated for Non-Small Cell Lung Cancer in the Left Upper Division Open
View article: Predicting Functional Recovery and Quality of Life in Older Patients Undergoing Colorectal Cancer Surgery: Real-World Data From the International GOSAFE Study
Predicting Functional Recovery and Quality of Life in Older Patients Undergoing Colorectal Cancer Surgery: Real-World Data From the International GOSAFE Study Open
PURPOSE The GOSAFE study evaluates risk factors for failing to achieve good quality of life (QoL) and functional recovery (FR) in older patients undergoing surgery for colon and rectal cancer. METHODS Patients age 70 years and older underg…
View article: SIOG COVID-19 Working Group recommendations on COVID-19 therapeutic approaches in older adults with cancer
SIOG COVID-19 Working Group recommendations on COVID-19 therapeutic approaches in older adults with cancer Open
View article: Quality Surgical Care and Outcomes for Patients With Non–Small-Cell Lung Cancer
Quality Surgical Care and Outcomes for Patients With Non–Small-Cell Lung Cancer Open
The curative potential of surgical resection for non-small-cell lung cancer (NSCLC) was established nearly a century ago, with pneumonectomy initially constituting the primary operative approach. 1As surgical techniques became more refined…
View article: Implementing 4-meter gait speed as a routine vital sign in a thoracic surgery clinic
Implementing 4-meter gait speed as a routine vital sign in a thoracic surgery clinic Open
View article: Supplementary Methods from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer
Supplementary Methods from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer Open
Supplementary methods, including croplet digital PCR for MET D1228V; molecular docking study; Molecular Dynamics Simulations.
View article: Supplementary Figure S2 from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer
Supplementary Figure S2 from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer Open
Supplementary Figure S2 shows expression of D1228V mutation in PC9 cells as confirmed by RT-PCR and cDNA sequencing.
View article: Supplementary Figure Legends from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer
Supplementary Figure Legends from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer Open
Supplementary Figure Legends.
View article: Supplementary Table S2 from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer
Supplementary Table S2 from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer Open
Supplementary Table S2 shows type I and II MET kinase inhibitors and key trials studying their activity lung cancer populations enriched for MET-dependence.
View article: Supplementary Table S1 from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer
Supplementary Table S1 from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer Open
Supplementary Table S1 shows variants identified in pre-treatment and post-treatment tumor targeted next-generation sequencing (NGS).
View article: Data from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer
Data from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer Open
Amplified and/or mutated MET can act as both a primary oncogenic driver and as a promoter of tyrosine kinase inhibitor (TKI) resistance in non–small cell lung cancer (NSCLC). However, the landscape of MET-specific targeting agents r…
View article: Supplementary Figure S1 from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer
Supplementary Figure S1 from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer Open
Supplementary Figure S1 shows presence of the known EGFR exon 19 deletion and high level MET amplification, both of which had been present on prior tumor NGS.
View article: Supplementary Figure S2 from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer
Supplementary Figure S2 from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer Open
Supplementary Figure S2 shows expression of D1228V mutation in PC9 cells as confirmed by RT-PCR and cDNA sequencing.
View article: Supplementary Figure Legends from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer
Supplementary Figure Legends from Acquired <i>MET</i><sup>D1228V</sup> Mutation and Resistance to MET Inhibition in Lung Cancer Open
Supplementary Figure Legends.