Michael T. Watkins
YOU?
Author Swipe
View article: International neuroblastoma risk group consortium: a model of networking for rare cancers
International neuroblastoma risk group consortium: a model of networking for rare cancers Open
It is critical to share knowledge and harmonize approaches to optimize progress in rare cancers. The International Neuroblastoma Risk Group (INRG) Task Force was formed by the 4 major neuroblastoma cooperative groups in 2004 to achieve thi…
View article: Advancing Monogenic Diabetes Research and Clinical Care by Creating a Data Commons: The Precision Diabetes Consortium (PREDICT)
Advancing Monogenic Diabetes Research and Clinical Care by Creating a Data Commons: The Precision Diabetes Consortium (PREDICT) Open
Monogenic diabetes mellitus (MDM) is a group of relatively rare disorders caused by pathogenic variants in key genes that result in hyperglycemia. Lack of identified cases, along with absent data standards, and limited collaboration across…
View article: Extracting Electronic Health Record Neuroblastoma Treatment Data With High Fidelity Using the REDCap Clinical Data Interoperability Services Module
Extracting Electronic Health Record Neuroblastoma Treatment Data With High Fidelity Using the REDCap Clinical Data Interoperability Services Module Open
PURPOSE Although the International Neuroblastoma Risk Group Data Commons (INRGdc) has enabled seminal large cohort studies, the research is limited by the lack of real-world, electronic health record (EHR) treatment data. To address this l…
View article: Accelerating pediatric Hodgkin lymphoma research: the Hodgkin Lymphoma Data Collaboration (NODAL)
Accelerating pediatric Hodgkin lymphoma research: the Hodgkin Lymphoma Data Collaboration (NODAL) Open
Data commons have proven to be an indispensable avenue for advancing pediatric cancer research by serving as unified information technology platforms that, when coupled with data standards, facilitate data sharing. The Pediatric Cancer Dat…
View article: Using A Standardized Nomenclature to Semantically Map Oncology-Related Concepts from Common Data Models to a Pediatric Cancer Data Model.
Using A Standardized Nomenclature to Semantically Map Oncology-Related Concepts from Common Data Models to a Pediatric Cancer Data Model. Open
The Pediatric Cancer Data Commons (PCDC) comprises an international community whose ironclad commitment to data sharing is combatting pediatric cancer in an unprecedented way. The byproduct of their data sharing efforts is a gold-standard …
View article: 1283. Safety, Tolerability, and Pharmacokinetics of BRII-778, A Modified-Release Oral Formulation of Rilpivirine in Healthy Adult Subjects
1283. Safety, Tolerability, and Pharmacokinetics of BRII-778, A Modified-Release Oral Formulation of Rilpivirine in Healthy Adult Subjects Open
Background BRII-778 is a modified release (MR) formulation of rilpivirine for once-weekly (QW) oral administration. BRII-778 aims to prolong oral absorption, lower Cmax, relatively, and reduce peak to trough ratio achieved with a MR formul…
View article: 1282. Safety, Tolerability, and Pharmacokinetics of BRII-732, A Medoxomil Carbonate Prodrug of Islatravir in Healthy Adult Subjects
1282. Safety, Tolerability, and Pharmacokinetics of BRII-732, A Medoxomil Carbonate Prodrug of Islatravir in Healthy Adult Subjects Open
Background BRII-732, a prodrug of islatravir (ISL), is a potent HIV-1 nucleotide reverse transcriptase translocation inhibitor. Following oral absorption, BRII-732 is rapidly converted to ISL, which is metabolized intracellularly to the ac…
View article: P086: Advancing Pediatric Hodgkin Lymphoma Research Through NODAL
P086: Advancing Pediatric Hodgkin Lymphoma Research Through NODAL Open
Background: The Pediatric Cancer Data Commons (PCDC; University of Chicago, established in 2015) has provided a robust technical infrastructure to enable harmonization and utilization of big data to answer meaningful research questions for…
View article: ResultsMyWay: combining Fast Healthcare Interoperability Resources (FHIR), Clinical Quality Language (CQL), and informational resources to create a newborn screening application.
ResultsMyWay: combining Fast Healthcare Interoperability Resources (FHIR), Clinical Quality Language (CQL), and informational resources to create a newborn screening application. Open
Newborn screening (NBS) can be life-changing for the families of infants who test positive for a rare condition. While resources exist to support these families, there can be delays in sharing these resources due to communication lag betwe…
View article: LocalVar: a local variant collection manager to asynchronously detect synonyms, HGVS expression changes, and variant interpretation changes from ClinVar
LocalVar: a local variant collection manager to asynchronously detect synonyms, HGVS expression changes, and variant interpretation changes from ClinVar Open
While there are several public repositories of biological sequence variation data and associated annotations, there is little open-source tooling designed specifically for the upkeep of local collections of variant data. Many clinics curat…
View article: Translating Social Determinants of Health into Standardized Clinical Entities
Translating Social Determinants of Health into Standardized Clinical Entities Open
Social determinants of health (SDH) are a valuable source of health information which still are not fully utilized in the clinical space. Knowing that a certain patient has trouble finding transportation, has a potentially hazardous relati…
View article: FHIR Lab Reports: using SMART on FHIR and CDS Hooks to increase the clinical utility of pharmacogenomic laboratory test results.
FHIR Lab Reports: using SMART on FHIR and CDS Hooks to increase the clinical utility of pharmacogenomic laboratory test results. Open
Laboratory tests are a common aspect of clinical care and are the primary source of clinical genomic data. However, most laboratories use PDF documents to store and exchange the results of these tests. This locks the data into a static for…
View article: Risk score for nonhome discharge after lower extremity bypass
Risk score for nonhome discharge after lower extremity bypass Open
View article: Inhaled nitric oxide prevents systemic and pulmonary vasoconstriction due to hemoglobin-based oxygen carrier infusion: A case report
Inhaled nitric oxide prevents systemic and pulmonary vasoconstriction due to hemoglobin-based oxygen carrier infusion: A case report Open
View article: Implementing the VMC Specification to Reduce Ambiguity in Genomic Variant Representation.
Implementing the VMC Specification to Reduce Ambiguity in Genomic Variant Representation. Open
Current methods used for representing biological sequence variants allow flexibility, which has created redundancy within variant archives and discordance among variant representation tools. While research methodologies have been able to a…
View article: Disparity in Amputation Risk for Black Patients: Is It Constant Across All Surgeons?
Disparity in Amputation Risk for Black Patients: Is It Constant Across All Surgeons? Open
View article: Skin regeneration with all accessory organs following ablation with irreversible electroporation
Skin regeneration with all accessory organs following ablation with irreversible electroporation Open
Skin scar formation is a complex process that results in the formation of dense extracellular matrix (ECM) without normal skin appendages such as hair and glands. The absence of a scarless healing model in adult mammals prevents the develo…
View article: Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells
Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells Open
In patients with atherosclerotic complications of diabetes, impaired neovascularization of ischemic tissue in the myocardium and lower limb limits the ability of these tissues to compensate for poor perfusion. We identified 10 novel insuli…
View article: Spinal Cord Inflammation: Molecular Imaging after Thoracic Aortic Ischemia Reperfusion Injury
Spinal Cord Inflammation: Molecular Imaging after Thoracic Aortic Ischemia Reperfusion Injury Open
Purpose To evaluate whether noninvasive molecular imaging technologies targeting myeloperoxidase (MPO) can reveal early inflammation associated with spinal cord injury after thoracic aortic ischemia-reperfusion (TAR) in mice. Materials and…
View article: Photochemical Tissue Passivation Reduces Vein Graft Intimal Hyperplasia in a Swine Model of Arteriovenous Bypass Grafting
Photochemical Tissue Passivation Reduces Vein Graft Intimal Hyperplasia in a Swine Model of Arteriovenous Bypass Grafting Open
Background Bypass grafting remains the standard of care for coronary artery disease and severe lower extremity ischemia. Efficacy is limited by poor long‐term venous graft patency secondary to intimal hyperplasia ( IH ) caused by venous in…
View article: Revascularization and muscle adaptation to limb demand ischemia in diet-induced obese mice
Revascularization and muscle adaptation to limb demand ischemia in diet-induced obese mice Open
View article: Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins Open
The present proteomics study provides unprecedented insights into the expression and degradation of structural and regulatory components of the vascular extracellular matrix in varicosis.
View article: Effect of DNase I treatment and neutrophil depletion on acute limb ischemia-reperfusion injury in mice
Effect of DNase I treatment and neutrophil depletion on acute limb ischemia-reperfusion injury in mice Open
View article: Skin Rejuvenation with Non-Invasive Pulsed Electric Fields
Skin Rejuvenation with Non-Invasive Pulsed Electric Fields Open
Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and ext…
View article: Percutaneous Interventions in Aortic Disease
Percutaneous Interventions in Aortic Disease Open