Michaël Théron
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View article: Metabolic changes in dorsal root ganglia of newborn Wistar rats following <scp>LPS</scp> exposure to understand mechanisms of critical illness polyneuropathy
Metabolic changes in dorsal root ganglia of newborn Wistar rats following <span>LPS</span> exposure to understand mechanisms of critical illness polyneuropathy Open
Sepsis is a public health issue, associated with complications as critical illness polyneuropathy (CIP). This study investigates how mitochondrial dysfunction could contribute to CIP by examining metabolic changes in dorsal root ganglia (D…
View article: Evaluating metabolic changes in H9c2 cardiomyoblasts exposed to LPS: Towards understanding sepsis mechanisms
Evaluating metabolic changes in H9c2 cardiomyoblasts exposed to LPS: Towards understanding sepsis mechanisms Open
Sepsis is a major public health concern associated with high mortality rates, particularly due to sepsis-induced myocardial dysfunction (SIMD), which affects about 50% of septic patients. This study investigates how mitochondrial dysfuncti…
View article: Investigating <scp>M101</scp> 's Effect in Improving Cardiac and Diaphragmatic Mechanical and Functional Properties on Wistar Rat
Investigating <span>M101</span> 's Effect in Improving Cardiac and Diaphragmatic Mechanical and Functional Properties on Wistar Rat Open
Background The critical importance of effective oxygen delivery during organ preservation to prevent ischemia–reperfusion injury has been reported in the literature. Moreover, traditional preservation methods often fail to meet oxygenation…
View article: Effects of selenium, selenium‐enriched spirulina and phycocyanin on myocarditis stress parameters on LPS‐induced injury in H9c2 ventricular cardiomyoblasts
Effects of selenium, selenium‐enriched spirulina and phycocyanin on myocarditis stress parameters on LPS‐induced injury in H9c2 ventricular cardiomyoblasts Open
Myocarditis is strongly represented in septic patients and is associated with a higher mortality rate. Spirulina platensis (Spi), a blue‐green algae, has anti‐inflammatory properties and can be enriched with selenium, an antioxidant essent…
View article: N<sub>2</sub> exchanges in hyperbaric environments: toward a model based on physiological gas transport (O<sub>2</sub> and CO<sub>2</sub>)
N<sub>2</sub> exchanges in hyperbaric environments: toward a model based on physiological gas transport (O<sub>2</sub> and CO<sub>2</sub>) Open
This is the first model of inert gas transport based on the physiology of respiratory gas. It was built for O 2 delivery and validated against literature data; it was then transposed to N 2 exchanges. The transposition procedure was checke…
View article: Skin temperature influence on transcutaneous carbon dioxide (CO2) conductivity and skin blood flow in healthy human subjects at the arm and wrist
Skin temperature influence on transcutaneous carbon dioxide (CO2) conductivity and skin blood flow in healthy human subjects at the arm and wrist Open
Objective: present transcutaneous carbon dioxide (CO 2 )—tcpCO 2 —monitors suffer from limitations which hamper their widespread use, and call for a new tcpCO 2 measurement technique. However, the progress in this area is hindered by the l…
View article: Comparisons of a sodium selenite and a selenium-enriched Spirulina supplementation after a selenium deficiency on growth, tissue selenium concentrations, antioxidant activities and selenoprotein expression in rat
Comparisons of a sodium selenite and a selenium-enriched Spirulina supplementation after a selenium deficiency on growth, tissue selenium concentrations, antioxidant activities and selenoprotein expression in rat Open
Selenium contributes to physiological functions through its incorporation into selenoproteins. It is involved in oxidative stress defense. A selenium deficiency results in the onset or aggravation of pathologies. Following a deficiency, th…
View article: Carbon Dioxide Sensing—Biomedical Applications to Human Subjects
Carbon Dioxide Sensing—Biomedical Applications to Human Subjects Open
Carbon dioxide (CO2) monitoring in human subjects is of crucial importance in medical practice. Transcutaneous monitors based on the Stow-Severinghaus electrode make a good alternative to the painful and risky arterial “blood gases” sampli…
View article: Can selenium‐enriched spirulina supplementation ameliorate sepsis outcomes in selenium‐deficient animals?
Can selenium‐enriched spirulina supplementation ameliorate sepsis outcomes in selenium‐deficient animals? Open
In intensive care units, sepsis is the first cause of death. In this pathology, inflammation and oxidative status play a crucial role in patient outcomes. Interestingly, 92% of septic patients exhibit low selenium plasma concentrations (a …
View article: Measuring hemoglobin spectra: searching for carbamino-hemoglobin
Measuring hemoglobin spectra: searching for carbamino-hemoglobin Open
CO2Hb absorption spectrum was measured for the first time. Such spectrum being close to that of HHb, the use of a theoretical background based on pulse oximetry theory for noninvasive PaCO2 measurement seems extremely challenging.
View article: Endothelial function may be enhanced in the cutaneous microcirculation after a single air dive
Endothelial function may be enhanced in the cutaneous microcirculation after a single air dive Open
Introduction: The effects of scuba diving on the vessel wall have been studied mainly at the level of large conduit arteries. Data regarding the microcirculation are scarce and indicate that these two vascular beds are affected differently…
View article: A clinically relevant and bias-controlled murine model to study acute traumatic coagulopathy
A clinically relevant and bias-controlled murine model to study acute traumatic coagulopathy Open
Acute traumatic coagulopathy (ATC) is an acute and endogenous mechanism triggered by the association of trauma and hemorrhage. Several animal models have been developed, but some major biases have not yet been identified. Our aim was to de…
View article: Angiotensin Converting Enzyme Inhibitor Has a Protective Effect on Decompression Sickness in Rats
Angiotensin Converting Enzyme Inhibitor Has a Protective Effect on Decompression Sickness in Rats Open
Introduction: Commercial divers, high altitude pilots, and astronauts are exposed to some inherent risk of decompression sickness (DCS), though the mechanisms that trigger are still unclear. It has been previously showed that diving may in…
View article: Bioenergetic transcriptomic responses of European flounder (Platichthys flesus) populations in contrasted environments: impacts of pollution and global warming
Bioenergetic transcriptomic responses of European flounder (Platichthys flesus) populations in contrasted environments: impacts of pollution and global warming Open
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View article: Modelling and Simulating Complex Systems in Biology
Modelling and Simulating Complex Systems in Biology Open
Modelling and teaching complex biological systems is a difficult process. Multi-Agent Based Simulations (MABS) have proved to be an appropriate approach both in research and education when dealing with such systems including emergent, self…
View article: Age, weight and decompression sickness in rats
Age, weight and decompression sickness in rats Open
We believe that age is likely to be found associated with the probability of DCS in a larger dataset with a wider range of parameters, after accounting for the effect of weight.