Michael G. Thor
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View article: Spider toxin inhibits gating pore currents underlying periodic paralysis
Spider toxin inhibits gating pore currents underlying periodic paralysis Open
Significance Voltage-gated ion channels contain domains that have discrete functionalities. The central pore domain allows current flow and provides ion selectivity, whereas peripherally located voltage-sensing domains (VSDs) are needed fo…
View article: Dysfunction of NaV1.4, a skeletal muscle voltage-gated sodium channel, in sudden infant death syndrome: a case-control study
Dysfunction of NaV1.4, a skeletal muscle voltage-gated sodium channel, in sudden infant death syndrome: a case-control study Open
UK Medical Research Council, the Wellcome Trust, National Institute for Health Research, the British Heart Foundation, Biotronik, Cardiac Risk in the Young, Higher Education Funding Council for England, Dravet Syndrome UK, the Epilepsy Soc…
View article: Contrasting roles of <i>I</i><sub>h</sub> and the persistent sodium current at subthreshold voltages during naturalistic stimuli
Contrasting roles of <i>I</i><sub>h</sub> and the persistent sodium current at subthreshold voltages during naturalistic stimuli Open
The subthreshold activity of hippocampal CA1 pyramidal neurons is regulated by the persistent sodium current ( I NaP ) and the h-current ( I h ), carried by tetrodotoxin-sensitive sodium channels and hyperpolarization-activated cyclic-nucl…
View article: Loss-of-function mutations in<i>SCN4A</i>cause severe foetal hypokinesia or ‘classical’ congenital myopathy
Loss-of-function mutations in<i>SCN4A</i>cause severe foetal hypokinesia or ‘classical’ congenital myopathy Open
Congenital myopathies are a clinically and genetically heterogeneous group of muscle disorders characterized by congenital or early-onset hypotonia and muscle weakness, and specific pathological features on muscle biopsy. The phenotype ran…