Michael T. Chang
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View article: Utilizing a publicly accessible automated machine learning platform to enable diagnosis before tumor surgery
Utilizing a publicly accessible automated machine learning platform to enable diagnosis before tumor surgery Open
A deep automated machine learning model, created from a publicly available artificial intelligence tool, using pre-operative CT imaging alone, identified malignant transformation of inverted papilloma with excellent accuracy.
View article: Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation
Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation Open
Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease of the sinonasal cavity affecting millions worldwide. Its complex pathophysiology remains poorly understood, with emerging evidence implicating interactions between dive…
View article: Scoping review of deep learning research illuminates artificial intelligence chasm in otolaryngology-head and neck surgery
Scoping review of deep learning research illuminates artificial intelligence chasm in otolaryngology-head and neck surgery Open
View article: Unilateral Versus Bilateral Endoscopic Resection of Olfactory Neuroblastoma: Pooled Analysis From Prospective and Retrospective Multicenter Data
Unilateral Versus Bilateral Endoscopic Resection of Olfactory Neuroblastoma: Pooled Analysis From Prospective and Retrospective Multicenter Data Open
Background Olfactory neuroblastoma (ONB) is a rare sinonasal malignancy primarily treated with surgery. For tumors arising from the olfactory area, traditional treatment involves transcribriform resection of the anterior cranial fossa. Sur…
View article: Machine Learning of Endoscopy Images to Identify, Classify, and Segment Sinonasal Masses
Machine Learning of Endoscopy Images to Identify, Classify, and Segment Sinonasal Masses Open
Background We developed and assessed the performance of a machine learning model (MLM) to identify, classify, and segment sinonasal masses based on endoscopic appearance. Methods A convolutional neural network‐based model was constructed f…
View article: Utilization of ChatGPT for Rhinology Patient Education: Limitations in a Surgical Sub‐Specialty
Utilization of ChatGPT for Rhinology Patient Education: Limitations in a Surgical Sub‐Specialty Open
Objective To analyze the accuracy of ChatGPT‐generated responses to common rhinologic patient questions. Methods Ten common questions from rhinology patients were compiled by a panel of 4 rhinology fellowship‐trained surgeons based on clin…
View article: Feasibility of Automated Precharting using GPT-4 in New Specialty Referrals.
Feasibility of Automated Precharting using GPT-4 in New Specialty Referrals. Open
This study evaluates the feasibility of using GPT-4 to automate precharting for specialty referrals, focusing on new patients referred to an otolaryngology clinic for nasal congestion. We describe the design decisions and strategies tested…
View article: Persistent headache in granulomatosis with polyangiitis
Persistent headache in granulomatosis with polyangiitis Open
View article: Complications of Endonasal Odontoidectomy in Pediatric versus Adult Populations: A Systematic Review and Meta-Analysis
Complications of Endonasal Odontoidectomy in Pediatric versus Adult Populations: A Systematic Review and Meta-Analysis Open
Introduction Endonasal odontoidectomy (EO) is a procedure for addressing compressive pathology of the craniovertebral junction. While EO has been well established in adults, its complications and cervical fusion practices are less understo…
View article: Ipsilateral Nasoseptal Flaps in a Transpterygoid Approach: Technical Pearls and Reconstruction Outcomes
Ipsilateral Nasoseptal Flaps in a Transpterygoid Approach: Technical Pearls and Reconstruction Outcomes Open
Background Transpterygoid approaches to the skull base require dissection of the sphenopalatine artery, potentially compromising the option to harvest an ipsilateral nasoseptal flap (NSF) for reconstruction. In cases where other reconstruc…
View article: An Exploratory Analysis of the Chronic Rhinosinusitis Online Support Community
An Exploratory Analysis of the Chronic Rhinosinusitis Online Support Community Open
Objective To characterize the users of the largest chronic rhinosinusitis (CRS) online support communities (OSCs), describe the perceived benefits of OSCs for their users, and understand how patient medical decision making is affected by m…
View article: Environmental Risk Factors for Pediatric Epistaxis vary by Climate Zone
Environmental Risk Factors for Pediatric Epistaxis vary by Climate Zone Open
Introduction and Objective Prior studies have provided variable results regarding environmental risk factors for epistaxis. These studies were conducted in varying climate zones, which may explain discrepancies in results. The objective of…
View article: Immune-Epithelial Dynamics and Tissue Remodeling in Chronically Inflamed Nasal Epithelium via Multi-scaled Transcriptomics
Immune-Epithelial Dynamics and Tissue Remodeling in Chronically Inflamed Nasal Epithelium via Multi-scaled Transcriptomics Open
Chronic rhinosinusitis (CRS) is a common inflammatory disease of the sinonasal cavity that affects millions of individuals worldwide. The complex pathophysiology of CRS remains poorly understood, with emerging evidence implicating the orch…
View article: Development of a shortwave infrared sinuscope for the detection of cerebrospinal fluid leaks
Development of a shortwave infrared sinuscope for the detection of cerebrospinal fluid leaks Open
An endoscopic system based on SWIR narrowband imaging can provide an alternative in the future to invasive methods of CSF leak detection.
View article: Supplemental Figure 3. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
Supplemental Figure 3. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma Open
FACS analysis of Accx11 cells stained with PE-conjugated CD133 antibody. Expression analysis of Accx19 cultured cells by qRT-PCR demonstrates enrichment of CD133+ markers (A) and CD133- markers (B), similar to the pattern seen in Accx11 ce…
View article: Supplemental Table 4. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
Supplemental Table 4. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma Open
Genes and pathways suppressed by FABP7 knockdown in Accx11 cells.
View article: Supplemental Figure 4. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
Supplemental Figure 4. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma Open
Isolation and characterization of CD133 fractions from ACC xenografts. (A) Variation in the percentage of CD133+ cells across ACC xenografts. (B) qRT-PCR analysis of CD133 expression confirms adequate separation of CD133+ and CD133- cells …
View article: Supplemental Figure 1. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
Supplemental Figure 1. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma Open
Expression of SOX10, NOTCH1, FABP7, and CD133 in ACC tumor specimens from patients (P) and PDX (X). The comparison is based on previously produced Affymetrix data (6).
View article: Supplemental Figure 3. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
Supplemental Figure 3. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma Open
FACS analysis of Accx11 cells stained with PE-conjugated CD133 antibody. Expression analysis of Accx19 cultured cells by qRT-PCR demonstrates enrichment of CD133+ markers (A) and CD133- markers (B), similar to the pattern seen in Accx11 ce…
View article: Supplemental Figure 6. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
Supplemental Figure 6. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma Open
DAPT selectively increases cell death in CD133+ Accx11 cells as shown by PE-annexin and 7-AAD double staining. DMSO treatment serves as a control.
View article: Supplemental Table 3. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
Supplemental Table 3. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma Open
Suppressive effects of FABP7 depletion on gene expression in Accx11 cells.
View article: The Utility of a “Second-Look” Debridement Following Endonasal Skull Base Surgery in the Pediatric Population
The Utility of a “Second-Look” Debridement Following Endonasal Skull Base Surgery in the Pediatric Population Open
Background Sinonasal debridement is typically performed in the weeks following endonasal skull base surgery (ESBS). In the pediatric population, this second-look procedure may require general anesthesia; however, there is currently little …
View article: Rhinolithiasis misdiagnosed as intranasal osteoma: Diagnostic challenges in the telehealth era
Rhinolithiasis misdiagnosed as intranasal osteoma: Diagnostic challenges in the telehealth era Open
Rhinolithiasis is a rare clinical presentation and may be a diagnostic challenge, often mimicking other intranasal pathologies and difficult to differentiate based on imaging alone. We present the case of a 50-year-old patient with rhinoli…
View article: Development of a shortwave infrared (SWIR) sinuscope for the detection of cerebrospinal fluid (CSF) leaks
Development of a shortwave infrared (SWIR) sinuscope for the detection of cerebrospinal fluid (CSF) leaks Open
Significance CSF rhinorrhea (leakage of brain fluid from the nose) can be difficult to identify and currently requires invasive procedures such as intrathecal fluorescein which requires a lumbar drain placement. Fluorescein is also known t…
View article: Exploring Team-Sourced Hyperlinks to Address Navigation Challenges for Low-Vision Readers of Scientific Papers
Exploring Team-Sourced Hyperlinks to Address Navigation Challenges for Low-Vision Readers of Scientific Papers Open
Reading academic papers is a fundamental part of higher education and research, but navigating these information-dense texts can be challenging. In particular, low-vision readers using magnification encounter additional barriers to quickly…
View article: Novel Therapies in Olfactory Disorders
Novel Therapies in Olfactory Disorders Open
View article: Inferior Meatus Augmentation Procedure (<scp>IMAP</scp>) for Treatment of Empty Nose Syndrome
Inferior Meatus Augmentation Procedure (<span>IMAP</span>) for Treatment of Empty Nose Syndrome Open
View article: ER Unfolded Protein Response in Liver In Vivo Is Characterized by Reduced, Not Increased, De Novo Lipogenesis and Cholesterol Synthesis Rates with Uptake of Fatty Acids from Adipose Tissue: Integrated Gene Expression, Translation Rates and Metabolic Fluxes
ER Unfolded Protein Response in Liver In Vivo Is Characterized by Reduced, Not Increased, De Novo Lipogenesis and Cholesterol Synthesis Rates with Uptake of Fatty Acids from Adipose Tissue: Integrated Gene Expression, Translation Rates and Metabolic Fluxes Open
The unfolded protein response in the endoplasmic reticulum (UPRER) is involved in a number of metabolic diseases. Here, we characterize UPRER-induced metabolic changes in mouse livers in vivo through metabolic labeling and mass spectrometr…
View article: Sinonasal Ewing sarcoma misdiagnosed as recurrent glomangiopericytoma: Case report and literature review
Sinonasal Ewing sarcoma misdiagnosed as recurrent glomangiopericytoma: Case report and literature review Open
We present the case of a patient with a sinonasal mass diagnosed as glomangiopericytoma on initial resection. The patient experienced multiple recurrences over ten years, undergoing endoscopic resection each time and ultimately adjunctive …
View article: Oral Corticosteroids Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis Without Nasal Polyposis
Oral Corticosteroids Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis Without Nasal Polyposis Open
ClinicalTrials.gov Identifier: NCT02748070.