R. Michael Tuttle
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View article: Effect of GLP-1 Receptor Agonists on Patients with Thyroid Carcinomas Undergoing Active Surveillance
Effect of GLP-1 Receptor Agonists on Patients with Thyroid Carcinomas Undergoing Active Surveillance Open
Context Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as effective therapies for diabetes mellitus and obesity. Their effect on nonmedullary thyroid malignancies remains unclear. Objective To evaluate the impact of GLP-…
View article: The impact of macroscopic invasion to the recurrent laryngeal nerve alone in papillary thyroid carcinoma
The impact of macroscopic invasion to the recurrent laryngeal nerve alone in papillary thyroid carcinoma Open
Background Gross extrathyroidal extension (macroETE) is one of the most important predictors of survival in papillary thyroid carcinoma (PTC). The aim of this study is to determine the impact of macroETE to the recurrent laryngeal nerve al…
View article: Impact of artificial intelligence-based and traditional image preprocessing and resampling on MRI-based radiomics for classification of papillary thyroid carcinoma
Impact of artificial intelligence-based and traditional image preprocessing and resampling on MRI-based radiomics for classification of papillary thyroid carcinoma Open
Objectives This study aims to evaluate the impact of image preprocessing methods, including traditional and artificial intelligence (AI)-based techniques, on the performance of MRI-based radiomics for predicting tumour aggressiveness in pa…
View article: Papillary thyroid carcinoma tall cell subtype (<scp>PTC‐TC</scp>) and high‐grade differentiated thyroid carcinoma tall cell phenotype (<scp>HGDTC‐TC</scp>) have different clinical behaviour: a retrospective study of 1456 patients
Papillary thyroid carcinoma tall cell subtype (<span>PTC‐TC</span>) and high‐grade differentiated thyroid carcinoma tall cell phenotype (<span>HGDTC‐TC</span>) have different clinical behaviour: a retrospective study of 1456 patients Open
Aims Papillary thyroid carcinoma, tall cell subtype (PTC‐TC) is a potentially aggressive histotype. The latest World Health Organisation (WHO) classification introduced a novel class of tumours; namely, high‐grade differentiated thyroid ca…
View article: Response to Letter to the Editor From Jagannath and Mayilvaganan: “Is Multifocality a Predictor of Poor Outcome in Childhood and Adolescent Papillary Thyroid Carcinoma?”
Response to Letter to the Editor From Jagannath and Mayilvaganan: “Is Multifocality a Predictor of Poor Outcome in Childhood and Adolescent Papillary Thyroid Carcinoma?” Open
Journal Article Accepted manuscript Response to Letter to the Editor from Jagannath and Mayilvaganan: "Is Multifocality a Predictor of Poor Outcome in Childhood and Adolescent Papillary Thyroid Carcinoma?" Get access Daniel W Scholfield, F…
View article: Active surveillance for micropapillary thyroid carcinoma: a clinical review
Active surveillance for micropapillary thyroid carcinoma: a clinical review Open
With the rapid rise in the incidence of micropapillary carcinoma, there is increasing concern about its overdiagnosis and overtreatment. There is considerable interest in managing patients with micropapillary carcinoma with active surveill…
View article: Partial Thyroidectomy With Incidental Metastatic Lymph Nodes
Partial Thyroidectomy With Incidental Metastatic Lymph Nodes Open
Importance The need for completion thyroidectomy in patients with incidental metastatic lymph nodes after partial thyroidectomy is unclear. Objective To investigate the outcomes of patients with incidental metastatic lymph nodes following …
View article: Association of the Genomic Profile of Medullary Thyroid Carcinoma with Tumor Characteristics and Clinical Outcomes in an International Multicenter Study
Association of the Genomic Profile of Medullary Thyroid Carcinoma with Tumor Characteristics and Clinical Outcomes in an International Multicenter Study Open
Purpose: The prognostic importance of RET and RAS mutations and their relationship to clinicopathologic parameters and outcomes in medullary thyroid carcinoma (MTC) need to be clarified. Experimental Desig…
View article: Toward individualized dosimetry for radiopharmaceutical therapy in day-to-day clinical practice of nuclear oncology: overcoming heterogeneity of radiation-absorbed dose to tumor and critical organs
Toward individualized dosimetry for radiopharmaceutical therapy in day-to-day clinical practice of nuclear oncology: overcoming heterogeneity of radiation-absorbed dose to tumor and critical organs Open
View article: Is There a Role for Levothyroxine Therapy in Euthyroid Patients on Active Surveillance for Papillary Microcarcinoma?
Is There a Role for Levothyroxine Therapy in Euthyroid Patients on Active Surveillance for Papillary Microcarcinoma? Open
View article: Thyroglobulin and thyroglobulin antibody: an updated clinical and laboratory expert consensus
Thyroglobulin and thyroglobulin antibody: an updated clinical and laboratory expert consensus Open
Objective Thyroglobulin measurement is the cornerstone of modern management of differentiated thyroid cancer, with clinical decisions on treatment and follow-up based on the results of such measurements. However, numerous factors need to b…
View article: Is Multifocality a Predictor of Poor Outcome in Childhood and Adolescent Papillary Thyroid Carcinoma?
Is Multifocality a Predictor of Poor Outcome in Childhood and Adolescent Papillary Thyroid Carcinoma? Open
Context Total thyroidectomy in pediatric papillary thyroid carcinoma (PTC) is recommended in national guidelines because of the high incidence of multifocal disease (MFD). Objective To determine the incidence of MFD in childhood and adoles…
View article: The use of single-timepoint images to link administered radioiodine activity (MBq) to a prescribed lesion radiation-absorbed dose (cGy): a regression-based prediction interval tool for the management of well-differentiated thyroid cancer patients
The use of single-timepoint images to link administered radioiodine activity (MBq) to a prescribed lesion radiation-absorbed dose (cGy): a regression-based prediction interval tool for the management of well-differentiated thyroid cancer patients Open
View article: Diffuse Sclerosing Papillary Thyroid Carcinoma: Clinicopathological Characteristics and Prognostic Implications Compared with Classic and Tall Cell Papillary Thyroid Cancer
Diffuse Sclerosing Papillary Thyroid Carcinoma: Clinicopathological Characteristics and Prognostic Implications Compared with Classic and Tall Cell Papillary Thyroid Cancer Open
View article: Supplementary Table 2. from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Supplementary Table 2. from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
All IMPACT mutation calls. Tumors previously published by Landa et al (1) are highlighted in blue.
View article: Supplementary legend from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Supplementary legend from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
Supplementary legend
View article: Data from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Data from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
Purpose: Patients with anaplastic thyroid cancer (ATC) have a very high death rate. In contrast, deaths from non-anaplastic thyroid (NAT) cancer are much less common. The genetic alterations in fatal NAT cancers have not been report…
View article: Figure S3 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Figure S3 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
Comparison of the most commonly mutated genes in fatal WDTC compared to nonfatal WDTC (TCGA)is shown in (A). Comparison of the most commonly mutated genes in fatal PDTC compared to nonfatal PDTC is shown in (B).
View article: Figure S1 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Figure S1 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
EIF1AX mutations in fatal non-anaplastic thyroid cancer.
View article: Figure S2 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Figure S2 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
Mutations in DNA damage control (A), RAS/PI3K/AkT/MTOR pathways (B), chromatin modifying genes (C) and receptor tyrosine kinase genes (RTKs) (D) in fatal non-anaplastic thyroid cancer.
View article: Figure S3 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Figure S3 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
Comparison of the most commonly mutated genes in fatal WDTC compared to nonfatal WDTC (TCGA)is shown in (A). Comparison of the most commonly mutated genes in fatal PDTC compared to nonfatal PDTC is shown in (B).
View article: Table S1 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Table S1 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
List of 410 genes in IMPACT sequencing platform
View article: Supplementary legend from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Supplementary legend from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
Supplementary legend
View article: Figure S2 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Figure S2 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
Mutations in DNA damage control (A), RAS/PI3K/AkT/MTOR pathways (B), chromatin modifying genes (C) and receptor tyrosine kinase genes (RTKs) (D) in fatal non-anaplastic thyroid cancer.
View article: Data from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Data from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
Purpose: Patients with anaplastic thyroid cancer (ATC) have a very high death rate. In contrast, deaths from non-anaplastic thyroid (NAT) cancer are much less common. The genetic alterations in fatal NAT cancers have not been report…
View article: Supplementary Table 2. from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Supplementary Table 2. from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
All IMPACT mutation calls. Tumors previously published by Landa et al (1) are highlighted in blue.
View article: Table S1 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Table S1 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
List of 410 genes in IMPACT sequencing platform
View article: Figure S1 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Figure S1 from Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of <i>MED12</i> and <i>RBM10</i> as Novel Thyroid Cancer Genes Associated with Tumor Virulence Open
EIF1AX mutations in fatal non-anaplastic thyroid cancer.
View article: Data from Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for <i>BRAF, PIK3CA</i>, and <i>AKT1</i>
Data from Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for <i>BRAF, PIK3CA</i>, and <i>AKT1</i> Open
Patients with poorly differentiated thyroid cancers (PDTC), anaplastic thyroid cancers (ATC), and radioactive iodine-refractory (RAIR) differentiated thyroid cancers have a high mortality, particularly if positive on [18F]fluoro…
View article: Supplementary Figure Legend, Tables 1-3 from Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for <i>BRAF, PIK3CA</i>, and <i>AKT1</i>
Supplementary Figure Legend, Tables 1-3 from Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for <i>BRAF, PIK3CA</i>, and <i>AKT1</i> Open
Supplementary Figure Legend, Tables 1-3 from Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA, and AKT1