Michael V. Gonzalez
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View article: Single Cell Sequencing Identifies Distinct Cellular Alterations in Impaired Aged and Diabetic Wounds
Single Cell Sequencing Identifies Distinct Cellular Alterations in Impaired Aged and Diabetic Wounds Open
Impaired wound healing in aged and diabetic wounds involves complex cellular dysregulation that hinders tissue repair. Using single‐cell RNA sequencing (scRNA‐seq) and validation techniques, we investigated impaired wound healing to identi…
View article: Somatic mutation discovery in idiopathic multicentric castleman disease (iMCD) lymph node tissue identifies dysregulated intracellular calcium signaling as a potential disease mechanism and therapeutic target
Somatic mutation discovery in idiopathic multicentric castleman disease (iMCD) lymph node tissue identifies dysregulated intracellular calcium signaling as a potential disease mechanism and therapeutic target Open
Background: Idiopathic multicentric Castleman disease (iMCD) is a rare, atypical lymphoproliferative disorder with significant morbidity and mortality and unknown etiology. Given the clinico-pathologic similarities between iMCD and several…
View article: Distinct interleukin-6 production in IPL and TAFRO subtypes of idiopathic multicentric Castleman disease
Distinct interleukin-6 production in IPL and TAFRO subtypes of idiopathic multicentric Castleman disease Open
Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder characterized by systemic inflammation and lymphadenopathy. Two major clinical subtypes, idiopathic plasmacytic lymphadenopathy (iMCD-IPL) and iMCD wit…
View article: GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice
GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice Open
Introduction GM-CSF is a pro-inflammatory cytokine that promotes an inflammatory phenotype in myeloid cells. The extent and pattern of GM-CSF expression in immune cells have not been fully elucidated. Our goal was to advance this topic usi…
View article: A patient-derived CABIN1 mutation recapitulates features of idiopathic multicentric Castleman disease in a mouse model
A patient-derived CABIN1 mutation recapitulates features of idiopathic multicentric Castleman disease in a mouse model Open
View article: Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection
Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection Open
View article: GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice
GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice Open
The full GM-CSF expression spectrum in immune cells remains unclear, while CD4□ T cells are the primary source. Using novel GM-CSF reporter/fate reporter transgenic mice, we tracked ongoing and past (YFP + ) GM-CSF expression in various im…
View article: The Involvement of PI3K–Akt Signaling in the Clinical and Pathological Findings of Idiopathic Multicentric Castleman Disease–Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, and Organomegaly and Not Otherwise Specified Subtypes
The Involvement of PI3K–Akt Signaling in the Clinical and Pathological Findings of Idiopathic Multicentric Castleman Disease–Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, and Organomegaly and Not Otherwise Specified Subtypes Open
Idiopathic multicentric Castleman disease is a rare lymphoproliferative disorder that is clinically classified into idiopathic plasmacytic lymphadenopathy (IPL); thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFR…
View article: Common connective tissue disorder and anti-cytokine autoantibodies are enriched in idiopathic multicentric castleman disease patients
Common connective tissue disorder and anti-cytokine autoantibodies are enriched in idiopathic multicentric castleman disease patients Open
Introduction Idiopathic Multicentric Castleman Disease (iMCD) is a polyclonal lymphoproliferative disorder involving cytokine storms that can lead to organ failure and death. The cause of iMCD is unknown, but some clinical evidence suggest…
View article: IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints
IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints Open
How IRF7 promotes autoimmune B cell responses and systemic autoimmunity is unclear. Analysis of spontaneous SLE-prone mice deficient in IRF7 uncovered the IRF7 role in regulating autoimmune germinal center (GC), plasma cell (PC) and autoan…
View article: Identifying and Targeting TNF Signaling in Idiopathic Multicentric Castleman’s Disease
Identifying and Targeting TNF Signaling in Idiopathic Multicentric Castleman’s Disease Open
View article: No evidence for active viral infection in unicentric and idiopathic multicentric Castleman disease by Viral-Track analysis
No evidence for active viral infection in unicentric and idiopathic multicentric Castleman disease by Viral-Track analysis Open
Castleman disease (CD) is a rare hematologic disorder characterized by pathologic lymph node changes and a range of symptoms due to excessive cytokine production. While uncontrolled infection with human herpesvirus-8 (HHV-8) is responsible…
View article: Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling
Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling Open
View article: Single-Step GWAS Multi-Trait Threshold-Linear Model for Growth Rate and Heteroblasty in <i>Eucalyptus globulus</i>
Single-Step GWAS Multi-Trait Threshold-Linear Model for Growth Rate and Heteroblasty in <i>Eucalyptus globulus</i> Open
Genome-wide association studies (GWAS) have provided significant insights into identifying variants associated with complex traits, but they have contributed little to the study of categorical data. The aim of this study was to identify ge…
View article: Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment
Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment Open
CD8+ T cell dysfunction impedes antitumor immunity in solid cancers, but the underlying mechanisms are diverse and poorly understood. Extracellular matrix (ECM) composition has been linked to impaired T cell migration and enhanced tumor pr…
View article: Inhibition of NFAT promotes loss of tissue resident uterine natural killer cells and attendant pregnancy complications in humans
Inhibition of NFAT promotes loss of tissue resident uterine natural killer cells and attendant pregnancy complications in humans Open
Uterine natural killer cells (uNKs) are a tissue resident lymphocyte population that are critical for pregnancy success. Although mouse models have demonstrated that NK deficiency results in abnormal placentation and poor pregnancy outcome…
View article: Immune‐mediated thrombocytopenia and IL‐6‐mediated thrombocytosis observed in idiopathic multicentric Castleman disease
Immune‐mediated thrombocytopenia and IL‐6‐mediated thrombocytosis observed in idiopathic multicentric Castleman disease Open
Summary Idiopathic multicentric Castleman disease (iMCD) is a rare haematological disorder characterized by generalized lymphadenopathy with atypical histopathological features and systemic inflammation caused by a cytokine storm involving…
View article: Re-epithelialization of Diabetic Skin and Mucosal Wounds is Rescued by Treatment with Epigenetic Inhibitors
Re-epithelialization of Diabetic Skin and Mucosal Wounds is Rescued by Treatment with Epigenetic Inhibitors Open
Wound healing is a complex, highly regulated process and is substantially disrupted by diabetes. We show here that human wound healing induces specific epigenetic changes that are exacerbated by diabetes in an animal model. We identified e…
View article: Reepithelialization of Diabetic Skin and Mucosal Wounds Is Rescued by Treatment With Epigenetic Inhibitors
Reepithelialization of Diabetic Skin and Mucosal Wounds Is Rescued by Treatment With Epigenetic Inhibitors Open
Wound healing is a complex, highly regulated process and is substantially disrupted by diabetes. We show here that human wound healing induces specific epigenetic changes that are exacerbated by diabetes in an animal model. We identified e…
View article: Re-epithelialization of Diabetic Skin and Mucosal Wounds is Rescued by Treatment with Epigenetic Inhibitors
Re-epithelialization of Diabetic Skin and Mucosal Wounds is Rescued by Treatment with Epigenetic Inhibitors Open
Wound healing is a complex, highly regulated process and is substantially disrupted by diabetes. We show here that human wound healing induces specific epigenetic changes that are exacerbated by diabetes in an animal model. We identified e…
View article: Re-epithelialization of Diabetic Skin and Mucosal Wounds is Rescued by Treatment with Epigenetic Inhibitors
Re-epithelialization of Diabetic Skin and Mucosal Wounds is Rescued by Treatment with Epigenetic Inhibitors Open
Wound healing is a complex, highly regulated process and is substantially disrupted by diabetes. We show here that human wound healing induces specific epigenetic changes that are exacerbated by diabetes in an animal model. We identified e…
View article: Regulatory T cell adoptive transfer alters uterine immune populations, increasing a novel MHC-IIlow macrophage associated with healthy pregnancy
Regulatory T cell adoptive transfer alters uterine immune populations, increasing a novel MHC-IIlow macrophage associated with healthy pregnancy Open
Intrauterine fetal demise (IUFD) – fetal loss after 20 weeks – affects 6 pregnancies per 1,000 live births in the United States, and the majority are of unknown etiology. Maternal systemic regulatory T cell (Treg) deficits have been implic…
View article: OC 27.2 Mechanistic Studies of Runt-Related Transcription Factor-1 (RUNX1)-Deficient Megakaryopoiesis and its Correction by RepSox (RS), a TGFβ-Receptor-1 Inhibitor
OC 27.2 Mechanistic Studies of Runt-Related Transcription Factor-1 (RUNX1)-Deficient Megakaryopoiesis and its Correction by RepSox (RS), a TGFβ-Receptor-1 Inhibitor Open
View article: A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease
A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease Open
Nonhematopoietic lymph node stromal cells (LNSCs) regulate lymphocyte trafficking, survival, and function for key roles in host defense, autoimmunity, alloimmunity, and lymphoproliferative disorders. However, the study of LNSCs in human di…
View article: Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality
Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality Open
(Cell Reports 34, 108917; March 30, 2021) After the publication of this paper, which was originally published with the March 30, 2021 issue of Cell Reports, the authors discovered that contributor Kanika Jain, who performed immunohistochem…
View article: GATA1 controls numbers of hematopoietic progenitors and their response to autoimmune neuroinflammation
GATA1 controls numbers of hematopoietic progenitors and their response to autoimmune neuroinflammation Open
GATA-binding factor 1 (GATA1) is a transcription factor that governs the development and function of multiple hematopoietic cell lineages. GATA1 is expressed in hematopoietic stem and progenitor cells (HSPCs) and is essential for erythroid…
View article: Human T follicular helper clones seed the germinal center–resident regulatory pool
Human T follicular helper clones seed the germinal center–resident regulatory pool Open
The mechanisms by which FOXP3 + T follicular regulatory (Tfr) cells simultaneously steer antibody formation toward microbe or vaccine recognition and away from self-reactivity remain incompletely understood. To explore underappreciated het…
View article: A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease
A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease Open
Non-hematopoietic lymph node stromal cells (LNSCs) regulate lymphocyte trafficking, survival, and function for key roles in host defense, autoimmunity, alloimmunity, and lymphoproliferative disorders. However, study of LNSCs in human disea…
View article: CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease
CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease Open
View article: Human T follicular helper clones seed the germinal center-resident regulatory pool
Human T follicular helper clones seed the germinal center-resident regulatory pool Open
How FOXP3 + T follicular regulatory (Tfr) cells simultaneously steer antibody formation toward microbe/vaccine recognition and away from self-reactivity remains unsettled. To explore human Tfr cell provenance, function and location heterog…