Manuel Becerra
YOU?
Author Swipe
Population Admixture and APOB Variant Landscape in Ecuadorian Mestizo Patients with Cardiac Diseases: Potential Implications for Familial Hypercholesterolemia Genetics Open
Apolipoprotein B (APOB) is a key structural component of atherogenic lipoproteins and one of the principal genes implicated in familial hypercholesterolemia (FH). However, APOB genetic variation remains poorly characterized in Latin Americ…
A Contemporary Review of Plasminogen Activator Inhibitor Type 1: Structure, Function, Genetic Architecture, and Intracellular/Extracellular Roles Open
Plasminogen activator inhibitor type 1 (PAI-1) is the key regulator of the fibrinolytic system, thereby acting as a potent mediator in thrombosis. Plasminogen activators such as PAI-1 mediate the conversion of the inactive zymogen plasmino…
A review of the capacity of xylooligosaccharides to modulate gut microbiota and promote health Open
In vitro and in vivo studies show that xylooligosaccharides could be a promising tool to ameliorate inflammatory and metabolic conditions related to obesity, inflammatory bowel disease and cancer, mostly via modulation of gut microbiota.
Editorial for Special Issue “Yeasts Biochemistry and Biotechnology” Open
Yeasts, both Saccharomyces and non-conventional strains, are currently the focus of active research due to their impressive applications in biotechnological bioprocesses, such as being hosts to produce recombinant proteins or main actors o…
Novel Microbial Enzymes with Industrial Applications Open
Eberhardt et al [...]
Xylanases from thermophilic archaea: A hidden treasure Open
[Abstract] Archaea are a domain of prokaryotic organisms that often inhabit extremophilic environments. Their enzymes are therefore of enormous biotechnological interest, due to their stability and activity in harsh conditions. Although bi…
Insights on Microbial Communities Inhabiting Non-Volcanic Hot Springs Open
The northwest of Spain has an abundance of non-volcanic hot springs that, until recently, had only been used for thermalism activities. One of such hot springs, Muiño da Veiga, has now been explored using metagenomics to study the microbia…
Bioprospecting for Thermozymes and Characterization of a Novel Lipolytic Thermozyme Belonging to the SGNH/GDSL Family of Hydrolases Open
Functional screenings were conducted on two metagenomic libraries from hot springs in order to find novel thermozymes with potential biotechnological applications. These included enzymes acting on plant cell walls such as endoglucanases an…
Additional file 1 of Characterization of a novel thermophilic metagenomic GH5 endoglucanase heterologously expressed in Escherichia coli and Saccharomyces cerevisiae Open
Additional file 1. Complete sequence of the gene encoding Cel776 with adapter sequences for subcloning in the Gateway system.
Comparative Metagenomic Analysis of Two Hot Springs From Ourense (Northwestern Spain) and Others Worldwide Open
With their circumneutral pH and their moderate temperature (66 and 68°C, respectively), As Burgas and Muiño da Veiga are two important human-use hot springs, previously studied with traditional culture methods, but never explored with a me…
The HMGB Protein KlIxr1, a DNA Binding Regulator of Kluyveromyces lactis Gene Expression Involved in Oxidative Metabolism, Growth, and dNTP Synthesis Open
In the traditional fermentative model yeast Saccharomyces cerevisiae, ScIxr1 is an HMGB (High Mobility Group box B) protein that has been considered as an important regulator of gene transcription in response to external changes like oxyge…
Bioconversion of Beet Molasses to Alpha-Galactosidase and Ethanol Open
Molasses are sub-products of the sugar industry, rich in sucrose and containing other sugars like raffinose, glucose, and fructose. Alpha-galactosidases (EC. 3.2.1.22) catalyze the hydrolysis of alpha-(1,6) bonds of galactose residues in g…
Cellulases from Thermophiles Found by Metagenomics Open
Cellulases are a heterogeneous group of enzymes that synergistically catalyze the hydrolysis of cellulose, the major component of plant biomass. Such reaction has biotechnological applications in a broad spectrum of industries, where they …
HMGB Proteins from Yeast to Human. Gene Regulation, DNA Repair and Beyond Open
HMGB proteins are characterized for containing one or more HMG-box domains and are well conserved from yeasts to higher eukaryotes. The HMG-box domain is formed by three α-helices with an L-shaped fold. Although HMGB proteins also have cyt…
Structural features of <i>Aspergillus niger</i> β‐galactosidase define its activity against glycoside linkages Open
β‐Galactosidases are biotechnologically interesting enzymes that catalyze the hydrolysis or transgalactosylation of β‐galactosides. Among them, the Aspergillus niger β‐galactosidase (AnβGal) belongs to the glycoside hydrolase family 35 ( G…
Dataset for: Structural features of Aspergillus niger β-galactosidase define its activity against glycoside linkages Open
β-galactosidases are biotechnologically interesting enzymes that catalyze the hydrolysis or transgalactosylation of β-galactosides. Among them, the Aspergillus niger β-galactosidase (AnβGal) belongs to the glycoside hydrolase family 35 (GH…
Dataset for: Structural features of Aspergillus niger β-galactosidase define its activity against glycoside linkages Open
β-galactosidases are biotechnologically interesting enzymes that catalyze the hydrolysis or transgalactosylation of β-galactosides. Among them, the Aspergillus niger β-galactosidase (AnβGal) belongs to the glycoside hydrolase family 35 (GH…