Michael Wallner
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View article: Establishing normative data for the evaluation of cognitive performance in Huntington’s disease considering the impact of gender, age, language, and education
Establishing normative data for the evaluation of cognitive performance in Huntington’s disease considering the impact of gender, age, language, and education Open
Background A declining cognitive performance is a hallmark of Huntington’s disease (HD). The neuropsychological battery of the Unified HD Rating Scale (UHDRS'99) is commonly used for assessing cognition. However, there is a need to identif…
View article: The ARCA Registry: A Collaborative Global Platform for Advancing Trial Readiness in Autosomal Recessive Cerebellar Ataxias
The ARCA Registry: A Collaborative Global Platform for Advancing Trial Readiness in Autosomal Recessive Cerebellar Ataxias Open
Autosomal recessive cerebellar ataxias (ARCAs) form an ultrarare yet expanding group of neurodegenerative multisystemic diseases affecting the cerebellum and other neurological or non-neurological systems. With the advent of targeted thera…
View article: Chemical modification of ragweed extract results in an increased safety profile while maintaining immunogenicity
Chemical modification of ragweed extract results in an increased safety profile while maintaining immunogenicity Open
Short or common ragweed (Ambrosia artemisiifolia), belonging to the plant family of Asteraceae, is an annual weed with pollination peak levels in late summer. Epidemiological studies revealed a sensitization prevalence of 23%–32.8% for the…
View article: Effect of structural stability on endolysosomal degradation and T‐cell reactivity of major shrimp allergen tropomyosin
Effect of structural stability on endolysosomal degradation and T‐cell reactivity of major shrimp allergen tropomyosin Open
Background Tropomyosins are highly conserved proteins, an attribute that forms the molecular basis for their IgE antibody cross‐reactivity. Despite sequence similarities, their allergenicity varies greatly between ingested and inhaled inve…
View article: A hybrid of two major <i>Blomia tropicalis</i> allergens as an allergy vaccine candidate
A hybrid of two major <i>Blomia tropicalis</i> allergens as an allergy vaccine candidate Open
Introduction Allergen‐specific immunotherapy (AIT) represents a curative approach for treating allergies. In the tropical and subtropical regions of the world, Blomia tropicalis (Blo t 5 and Blo t 21) is the likely dominant source of indoo…
View article: Retinoic acid‐loading of the major birch pollen allergen Bet v 1 may improve specific allergen immunotherapy: In silico, in vitro and in vivo data in BALB/c mice
Retinoic acid‐loading of the major birch pollen allergen Bet v 1 may improve specific allergen immunotherapy: In silico, in vitro and in vivo data in BALB/c mice Open
More than twenty different isoforms of Bet v 1, the major birch pollen allergen, have been identified, sharing an amino acid sequence identity of 95% and an almost identical tertiary structure.1 Despite their structural similarities, the i…
View article: Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin
Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin Open
Background Tropomyosins are highly conserved proteins, an attribute that forms the molecular basis for their IgE antibody cross-reactivity. Despite structural similarities, their allergenicity varies greatly between ingested and inhaled in…
View article: Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT
Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT Open
Clinical outcome of AIT depends on induction of blocking antibodies able to prevent the patient's own IgE from allergen binding. Monitoring of clinical efficacy seems to be best achieved using the inhibition mediator release assay, as deve…
View article: Rectangular Young tableaux with local decreases and the density method for uniform random generation (short version)
Rectangular Young tableaux with local decreases and the density method for uniform random generation (short version) Open
International audience
View article: NMR resonance assignments of a hypoallergenic isoform of the major birch pollen allergen Bet v 1
NMR resonance assignments of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 Open
In Northern America and Europe a great number of people are suffering from birch pollen allergy and pollen related food allergies. The trigger for these immunological reactions is the 17.5 kDa major birch pollen allergen Bet v 1, which bel…
View article: Comparing Proteolytic Fingerprints of Antigen-Presenting Cells during Allergen Processing
Comparing Proteolytic Fingerprints of Antigen-Presenting Cells during Allergen Processing Open
Endolysosomal processing has a critical influence on immunogenicity as well as immune polarization of protein antigens. In industrialized countries, allergies affect around 25% of the population. For the rational design of protein-based al…
View article: Amb a 1 isoforms: Unequal siblings with distinct immunological features
Amb a 1 isoforms: Unequal siblings with distinct immunological features Open
Background Ragweed pollen represents a major allergy risk factor. Ragweed extracts contain five different isoforms of the major allergen Amb a 1. However, the immunological characteristics of Amb a 1 isoforms are not fully investigated. He…
View article: Allergens of <b><i>Blomia tropicalis</i></b>: An Overview of Recombinant Molecules
Allergens of <b><i>Blomia tropicalis</i></b>: An Overview of Recombinant Molecules Open
Allergic diseases are considered a major problem for healthcare systems in both developed and developing countries. House dust mites are well-known triggers of allergic manifestations. While the Dermatophagoides genus is widely distributed…
View article: Expression and Characterization of Functional Recombinant Bet v 1.0101 in the Chloroplast of <b><i>Chlamydomonas reinhardtii</i></b>
Expression and Characterization of Functional Recombinant Bet v 1.0101 in the Chloroplast of <b><i>Chlamydomonas reinhardtii</i></b> Open
Background: Allergen immunotherapy (AIT) still plays a minor role in the treatment of allergic diseases. To improve the acceptance of AIT by allergic patients, the treatment has to become more convenient and efficacious. One possibility is…
View article: Pollen Allergens for Molecular Diagnosis
Pollen Allergens for Molecular Diagnosis Open
Pollen allergens are one of the main causes of type I allergies affecting up to 30% of the population in industrialized countries. Climatic changes affect the duration and intensity of pollen seasons and may together with pollution contrib…
View article: Tree pollen allergens—an update from a molecular perspective
Tree pollen allergens—an update from a molecular perspective Open
It is estimated that pollen allergies affect approximately 40% of allergic individuals. In general, tree pollen allergies are mainly elicited by allergenic trees belonging to the orders Fagales, Lamiales, Proteales, and Pinales. Over 25 ye…
View article: Pectate Lyase Pollen Allergens: Sensitization Profiles and Cross-Reactivity Pattern
Pectate Lyase Pollen Allergens: Sensitization Profiles and Cross-Reactivity Pattern Open
We could cluster pectate lyase allergens in four categories, Amb a 1, Art v 6, Cup a 1/Jun a 1, and Cry j 1, respectively, at which each category has the potential to sensitize predisposed individuals. The sensitization pattern of differen…
View article: Adverse Reactions Triggered by Amaranth Allergens-What We Know So Far from a Molecular Perspective
Adverse Reactions Triggered by Amaranth Allergens-What We Know So Far from a Molecular Perspective Open
The genus Amaranthus contains 44 species and belongs to the family of Amaranthaceae classified within the order of Caryophyllales.Within this order a number of allergenic species including Amaranthus retroflexus (Redroot pigweed), Beta vul…