Derrick Bennett
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View article: Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations
Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations Open
Smoking is the most important behavioural determinant of morbidity and mortality. Using machine learning on plasma levels of 2,917 proteins in the UK Biobank (n = 43,914), we develop a proteomic Smoking Index (pSIN) comprising 51 proteins …
View article: Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations Open
Aging and age-related diseases share convergent pathways at the proteome level. Here, using plasma proteomics and machine learning, we developed organismal and ten organ-specific aging clocks in the UK Biobank ( n = 43,616) and validated t…
View article: The COPD risk associated with adulthood weight change and early adulthood BMI: a prospective cohort study
The COPD risk associated with adulthood weight change and early adulthood BMI: a prospective cohort study Open
Background Gaps concerning general adiposity and chronic obstructive pulmonary disease (COPD) are delaying policies for weight interventions in COPD prevention, especially adiposity in early adulthood and weight changes during adulthood. M…
View article: Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts
Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts Open
Our findings suggested that expanded mCAs were significantly associated with all-cause and cause-specific deaths and could serve as a complement to the FI in providing a more comprehensive perspective on mortality risk, especially for canc…
View article: A simulation study of the impact of population-wide lifestyle modifications on life expectancy in the Chinese population
A simulation study of the impact of population-wide lifestyle modifications on life expectancy in the Chinese population Open
It is uncertain how much life expectancy of the Chinese population would improve under current and greater policy targets on lifestyle-based risk factors for chronic diseases and mortality. Here we report a simulation of how improvements i…
View article: Cardiometabolic health and risk of dementia and brain atrophy: a community-based prospective cohort study of 0.5 million adults in China
Cardiometabolic health and risk of dementia and brain atrophy: a community-based prospective cohort study of 0.5 million adults in China Open
Wellcome Trust, MRC, BHF, CR-UK, Kadoorie Charitable Foundation, Chinese MoST and NSFC.
View article: Associations of 2923 Olink proteins with demographic, lifestyle, environmental and health characteristics in middle-aged Chinese adults
Associations of 2923 Olink proteins with demographic, lifestyle, environmental and health characteristics in middle-aged Chinese adults Open
Previous studies have identified a large number of genetic variants affecting plasma levels of proteins, but little is known about the non-genetic factors influencing plasma levels of proteins in diverse populations. We measured plasma lev…
View article: Causal relevance of new-onset type 2 diabetes mellitus and cancer risk in Chinese adults
Causal relevance of new-onset type 2 diabetes mellitus and cancer risk in Chinese adults Open
Background The prevalence of type 2 diabetes mellitus (T2DM) is increasing in China, and T2DM is linked to higher risk of several cancers, particularly obesity-related cancers (ORCs). Whether these associations are causal remains unclear d…
View article: Contrasting associations of blood lipids with risk of myocardial infarction in Chinese and European adults
Contrasting associations of blood lipids with risk of myocardial infarction in Chinese and European adults Open
Aims Little is known about the importance of blood lipids for risk of myocardial infarction (MI) in Chinese vs. European populations. We compared the associations with MI of apolioprotein B (ApoB) vs. low-density lipoprotein cholesterol (L…
View article: The active cohort: a population-based smartphone intervention for health outcomes
The active cohort: a population-based smartphone intervention for health outcomes Open
Background The Clalit Active Cohort Study (CACS) assess the impact of lifestyle factors, particularly physical activity, on short- and long-term health outcomes using real-world data. Launched in January 2021, CACS focuses on Clalit Health…
View article: Data Resource Profile: the Physical Activity Cohort Repository (PACe)
Data Resource Profile: the Physical Activity Cohort Repository (PACe) Open
Key Features * The Physical Activity Cohort Repository (PACe) project created a searchable online database of cohort studies that have prospectively collected data on physical activity and/or sedentary behaviour (self-report and/or device-…
View article: Prospective associations of diabetes with 15 cancers in 2.2 million UK and Chinese adults
Prospective associations of diabetes with 15 cancers in 2.2 million UK and Chinese adults Open
Background Diabetes has been associated with the risk of numerous cancers, but the causal relevance of many of these associations remains unclear. Methods We investigated associations between diabetes and risks of 15 cancers using Cox-regr…
View article: Incorporation of Patient and Public Involvement in Statistical Methodology Research: Summary of Workshop Proceedings
Incorporation of Patient and Public Involvement in Statistical Methodology Research: Summary of Workshop Proceedings Open
Patient and Public Involvement (PPI) is well‐established in applied health research but remains under utilised in statistical methodology research due to perceived irrelevance and communication challenges. This paper summarises a one‐day w…
View article: Corrigendum to Associations of reallocating sedentary leisure-time to alternative discretionary movement behaviours with incident cardiometabolic diseases in 0.5 million Chinese adults. The Lancet Regional Health—Western Pacific, Volume 57, 101524
Corrigendum to Associations of reallocating sedentary leisure-time to alternative discretionary movement behaviours with incident cardiometabolic diseases in 0.5 million Chinese adults. The Lancet Regional Health—Western Pacific, Volume 57, 101524 Open
[This corrects the article DOI: 10.1016/j.lanwpc.2025.101524.].
View article: Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke
Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke Open
BACKGROUND: Analyses of genomic and proteomics data in prospective biobank studies in diverse populations may discover novel or repurposing drug targets for stroke. METHODS: We extracted individual cis -protein quantitative trait locus for…
View article: Causal Relevance of Lp(a) for Coronary Heart Disease and Stroke Types in East Asian and European Ancestry Populations: A Mendelian Randomization Study
Causal Relevance of Lp(a) for Coronary Heart Disease and Stroke Types in East Asian and European Ancestry Populations: A Mendelian Randomization Study Open
BACKGROUND: Elevated plasma levels of Lp(a) [lipoprotein(a)] are a causal risk factor for coronary heart disease and stroke in European individuals, but the causal relevance of Lp(a) for different stroke types and in East Asian individuals…
View article: Long-term exposure to fine particulate matter interacting with individual conditions increase breast cancer incidence: a large-scale Chinese cohort
Long-term exposure to fine particulate matter interacting with individual conditions increase breast cancer incidence: a large-scale Chinese cohort Open
Background Breast cancer is the most frequently diagnosed malignancy among women worldwide. This study aimed to investigate the impact of long-term fine particulate matter (PM2.5) exposure on breast cancer incidence in a cohort of 281,152 …
View article: Association of Daily Steps with Incident Nonalcoholic Fatty Liver Disease: Evidence from the UK Biobank Cohort
Association of Daily Steps with Incident Nonalcoholic Fatty Liver Disease: Evidence from the UK Biobank Cohort Open
Purpose Low physical activity has been shown to be associated with a higher risk of nonalcoholic fatty liver disease (NAFLD). However, the strength and shape of this association are currently uncertain due to a reliance on self-reported ph…
View article: Predictive performance of wearable sensors for mortality risk in older adults: a model development and validation study
Predictive performance of wearable sensors for mortality risk in older adults: a model development and validation study Open
Background: Many adults in high-income countries carry a device capable of measuring physical-activity behaviour. Thus, there is public health need to understand whether such data can enhance prediction of future health outcomes. We aimed …
View article: Phenome-wide association of physical activity with morbidity and mortality risk in China: A prospective cohort study
Phenome-wide association of physical activity with morbidity and mortality risk in China: A prospective cohort study Open
Research in high-income countries has established the health benefits of physical activity (PA), but evidence from low- and middle-income countries, including China, where PA patterns vary from those in high-income countries, remains limit…
View article: Phenome-wide associations of polygenic scores for schizophrenia and major depression in 100,000 Chinese adults
Phenome-wide associations of polygenic scores for schizophrenia and major depression in 100,000 Chinese adults Open
China faces significant mental health challenges, with unique associations between mental disorders and other traits observed in its population. Based on summary statistics in East Asian (EAS) and European (EUR) ancestries, we tested assoc…
View article: Mendelian randomization identifies proteins involved in neurodegenerative diseases
Mendelian randomization identifies proteins involved in neurodegenerative diseases Open
Proteins are involved in multiple biological functions. High-throughput technologies have allowed the measurement of thousands of proteins in population biobanks. In this study, we aimed to identify proteins related to Alzheimer’s disease,…
View article: Trends in stroke incidence, death, and disability outcomes in a multi-ethnic population: Auckland regional community stroke studies (1981–2022)
Trends in stroke incidence, death, and disability outcomes in a multi-ethnic population: Auckland regional community stroke studies (1981–2022) Open
Health Research Council of New Zealand.