Ning Wang
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View article: Tolerogenic dendritic cells induced by withdrawal of polyunsaturated fatty acid DHA and mTOR inhibitor PP242 attenuate allograft rejection
Tolerogenic dendritic cells induced by withdrawal of polyunsaturated fatty acid DHA and mTOR inhibitor PP242 attenuate allograft rejection Open
View article: Association Between Dietary Vitamin K Intake With Cancer Cachexia and Mortality: <scp>NHANES</scp> 1999–2018
Association Between Dietary Vitamin K Intake With Cancer Cachexia and Mortality: <span>NHANES</span> 1999–2018 Open
Research on the association between the development of cancer cachexia and dietary nutrient intake remains insufficient. We discussed the screening of dietary intake risks for cancer cachexia and further investigated the impact of vitamin …
View article: A Study on the Variability of Content Creator Vitality on Social Media Platforms — A Case Study of “Zhou Daye Doesn’t Accept Aging” and “Chushi and Sanjiu
A Study on the Variability of Content Creator Vitality on Social Media Platforms — A Case Study of “Zhou Daye Doesn’t Accept Aging” and “Chushi and Sanjiu Open
In the increasingly competitive landscape of short video platforms, content creators often face the dilemma of “going viral is easy, staying relevant is hard.” This reflects the inherent instability between platform traffic allocation mech…
View article: Survival analysis of pneumoconiosis patients in Jiangsu Province from 1960 to 2024
Survival analysis of pneumoconiosis patients in Jiangsu Province from 1960 to 2024 Open
Introduction Pneumoconiosis is recognized as a major occupational health burden worldwide, especially in developing countries where industrial dust exposure is prevalent. This study aims to provide evidence for the development of preventio…
View article: Improved extrusion cooking technique (IECT) induces the formation of starch-lauric acid complexes: Evaluations of structure and properties
Improved extrusion cooking technique (IECT) induces the formation of starch-lauric acid complexes: Evaluations of structure and properties Open
View article: Interaction of artificial intelligence, mental disorders, and diverse data modalities: Potential treatment management based on the “method-disease-data” axis
Interaction of artificial intelligence, mental disorders, and diverse data modalities: Potential treatment management based on the “method-disease-data” axis Open
Although many previous studies have highlighted the advances in prediction models, instruments for pathological and histological diagnosis and treatment, as well as individualized treatment modalities in mental disorders, these previous sy…
View article: Drug selection based on pan-genomics genetic features of Mycobacterium tuberculosis
Drug selection based on pan-genomics genetic features of Mycobacterium tuberculosis Open
Tuberculosis, caused by Mycobacterium tuberculosis , is a severe and persistent global public health issue, particularly exacerbated by the emergence of multidrug-resistant and extensively drug-resistant strains. This study employed pan-ge…
View article: Efficiency and Safety of HAIC Combined with Lenvatinib and PD-1 Inhibitor for Advanced Hepatocellular Carcinoma with Lung Metastasis: A Multicenter Propensity Score Matching Analysis
Efficiency and Safety of HAIC Combined with Lenvatinib and PD-1 Inhibitor for Advanced Hepatocellular Carcinoma with Lung Metastasis: A Multicenter Propensity Score Matching Analysis Open
HAIC combined with lenvatinib and PD-1 inhibitor shows promise as a treatment for advanced HCC with lung metastases, offering improved prognosis and a manageable safety profile.
View article: Epigenetic orchestration of cancer-immune dynamics: mechanisms, technologies, and clinical advancements
Epigenetic orchestration of cancer-immune dynamics: mechanisms, technologies, and clinical advancements Open
This review systematically dissects how epigenetic alterations impair anti-tumour immunity at each stage of the CI cycle. It not only integrates fragmented mechanistic evidence but also emphasizes underexplored crosstalk between specific e…
View article: Csf1+ AD-MSCs promote stroke repair by activating the resident microglia
Csf1+ AD-MSCs promote stroke repair by activating the resident microglia Open
The potential of mesenchymal stromal cells (MSCs) in the treatment of hemorrhagic stroke has been demonstrated; however, their clinical efficacy remains inconsistent and further comprehensive studies on their mechanism of action are warran…
View article: Research progress on the mechanisms of CSF3R mutations in leukemogenesis and treatment strategies
Research progress on the mechanisms of CSF3R mutations in leukemogenesis and treatment strategies Open
Leukemia is a malignant clonal disease originating from hematopoietic stem cells. Its pathogenesis is associated with multiple factors, including biological, physical, chemical, genetic, and other hematological diseases. Previous studies h…
View article: A CD4+ T lymphocyte–specific TCR/GSDMD/IL-2 axis facilitates antitumor immunity
A CD4+ T lymphocyte–specific TCR/GSDMD/IL-2 axis facilitates antitumor immunity Open
Gasdermin (GSDM) family proteins mediate tumor pyroptosis and impact cancer progression, but other than that, their involvement in the tumor immune microenvironment remains largely unknown. Here, we show that activation of GSDMD in human t…
View article: High-accuracy physical property prediction for pure organics via molecular representation learning: bridging data to discovery
High-accuracy physical property prediction for pure organics via molecular representation learning: bridging data to discovery Open
The escalating energy crisis has spurred extensive research into organic compounds for energy-efficient applications, taking advantage of their environmental friendliness, cost-effective synthesis, and adaptable molecular structures. Tradi…
View article: Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurodegeneration in glaucoma through ahr/rage pathway
Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurodegeneration in glaucoma through ahr/rage pathway Open
View article: Glioma promotes macrophage immunosuppressive phenotype through ANXA1 in a methionine metabolism-dependent manner
Glioma promotes macrophage immunosuppressive phenotype through ANXA1 in a methionine metabolism-dependent manner Open
View article: Artificial intelligence in drug discovery: A comprehensive review with a case study on hyperuricemia, gout arthritis, and hyperuricemic nephropathy
Artificial intelligence in drug discovery: A comprehensive review with a case study on hyperuricemia, gout arthritis, and hyperuricemic nephropathy Open
This paper systematically reviews recent advances in artificial intelligence (AI), with a particular focus on machine learning (ML), across the entire drug discovery pipeline. Due to the inherent complexity, escalating costs, prolonged tim…
View article: DSG2 promotes pancreatic cancer stem cell maintenance via support of tumour and macrophage cellular cross-talk
DSG2 promotes pancreatic cancer stem cell maintenance via support of tumour and macrophage cellular cross-talk Open
View article: Triglyceride–Glucose-Based Anthropometric Indices for Predicting Incident Cardiovascular Disease: Relative Fat Mass (RFM) as a Robust Indicator
Triglyceride–Glucose-Based Anthropometric Indices for Predicting Incident Cardiovascular Disease: Relative Fat Mass (RFM) as a Robust Indicator Open
Background/Objectives: The triglyceride–glucose (TyG) index is a recognized marker for cardiovascular disease (CVD) risk linked to insulin resistance. Combining TyG with anthropometric indicators (AIs) may improve risk prediction, but the …
View article: First-day intracranial pressure correlates with ICU mortality in subarachnoid hemorrhage patients: an analysis of the MIMIC-IV database
First-day intracranial pressure correlates with ICU mortality in subarachnoid hemorrhage patients: an analysis of the MIMIC-IV database Open
Background The purpose of this study was to explore the optimal intracranial pressure (ICP) distribution of subarachnoid hemorrhage (SAH) patients on the first day in the intensive care unit (ICU) using data mining methods. Methods Continu…
View article: A bibliometric analysis of targeted therapy cardiotoxicity research in cancer patients (2004–2024)
A bibliometric analysis of targeted therapy cardiotoxicity research in cancer patients (2004–2024) Open
Background The management of long-term cardiotoxicity has become increasingly challenging despite the growing utilization of targeted therapies to enhance progression-free and overall survival rates. Although there is a proliferation of li…
View article: Rapid UPLC-MS/MS Determination of Amantadine and Rimantadine in Human Blood and Urine for Forensic Toxicology
Rapid UPLC-MS/MS Determination of Amantadine and Rimantadine in Human Blood and Urine for Forensic Toxicology Open
A rapid UPLC-MS/MS method was developed and validated for quantifying amantadine (AMD) and rimantadine (RIM) in human blood and urine. Sample preparation involved acetonitrile protein precipitation with amantadine-D6 as internal standard. …
View article: Overexpression of oncogenic polo-like kinase 1 disrupts the invasiveness, cell cycle, and apoptosis in synovial sarcoma
Overexpression of oncogenic polo-like kinase 1 disrupts the invasiveness, cell cycle, and apoptosis in synovial sarcoma Open
View article: PKD1-mediated phosphorylation at dopamine D2 receptor serine 365 site in dorsal striatum underlies cocaine-induced locomotor hyperactivity
PKD1-mediated phosphorylation at dopamine D2 receptor serine 365 site in dorsal striatum underlies cocaine-induced locomotor hyperactivity Open
View article: UA-IL-DLLME-LC-MS/MS Method for the Detection of Chlorfenapyr and Its Metabolites
UA-IL-DLLME-LC-MS/MS Method for the Detection of Chlorfenapyr and Its Metabolites Open
This study established an ultrasound-assisted ionic liquid–dispersive liquid–liquid microextraction combined with liquid chromatography–tandem mass spectrometry (UA-IL-DLLME-LC-MS/MS) method for the detection of chlorfenapyr and its toxic …
View article: 178 | CLINICAL CHARACTERISTICS AND MOLECULAR HETEROGENEITY IN FOLLICULAR LYMPHOMA WITH EXTRANODAL INVOLVEMENT
178 | CLINICAL CHARACTERISTICS AND MOLECULAR HETEROGENEITY IN FOLLICULAR LYMPHOMA WITH EXTRANODAL INVOLVEMENT Open
View article: ABS0005 ACONITINE: A POTENTIAL TREATMENT FOR RHEUMATOID ARTHRITIS
ABS0005 ACONITINE: A POTENTIAL TREATMENT FOR RHEUMATOID ARTHRITIS Open
View article: Application and Prospects of Traditional Chinese Medicine Syndrome Differentiation in the Prevention and Treatment of Hypertension in Middle-aged and Young Adults
Application and Prospects of Traditional Chinese Medicine Syndrome Differentiation in the Prevention and Treatment of Hypertension in Middle-aged and Young Adults Open
Hypertension in middle-aged and young adults has become a significant health concern in modern society, closely linked to lifestyle, emotional regulation, and dietary habits. The physiological characteristics and social stress of this grou…
View article: Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s disease
Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s disease Open
Choroid plexus (CP) enlargement and glymphatic dysfunction have been implicated in neurodegeneration, but their roles in Parkinson's disease (PD) remain unclear. This retrospective cross-sectional study examined associations among CP volum…
View article: Advancements in CRISPR/Cas systems for disease treatment
Advancements in CRISPR/Cas systems for disease treatment Open
View article: Chemotherapy cardiotoxicity research in cancer patients: a bibliometric and visual analysis (1994–2024)
Chemotherapy cardiotoxicity research in cancer patients: a bibliometric and visual analysis (1994–2024) Open
Background Recent advancements in medical technology have significantly boosted the survival rates of cancer patients. The potential toxicities that cancer treatments may induce in other areas of the human body have garnered increasing att…