Michael Wehr
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View article: Cortex-wide spatiotemporal motifs of theta oscillations are coupled to freely moving behavior
Cortex-wide spatiotemporal motifs of theta oscillations are coupled to freely moving behavior Open
Multisensory information is combined across the cortex and assimilated into the continuous production of ongoing behavior. In the hippocampus, theta oscillations (4–12 Hz) radiate as large-scale traveling waves, and serve as a scaffold for…
View article: Olfactory bulb tracks breathing rhythms and place in freely behaving mice
Olfactory bulb tracks breathing rhythms and place in freely behaving mice Open
Vertebrates sniff to control the odor samples that enter their nose. These samples can not only help identify odorous objects, but also locations and events. However, there is no receptor for place or time. Therefore, to take full advantag…
View article: Olfactory bulb tracks breathing rhythms and place in freely behaving mice
Olfactory bulb tracks breathing rhythms and place in freely behaving mice Open
Vertebrates sniff to control the odor samples that enter their nose. These samples can not only help identify odorous objects, but also locations and events. However, there is no receptor for place or time. Therefore, to take full advantag…
View article: Ketamine does not rescue plaque load or gap detection in the 5XFAD mouse model of Alzheimer's disease
Ketamine does not rescue plaque load or gap detection in the 5XFAD mouse model of Alzheimer's disease Open
Ketamine has received growing attention for its effects on neuroplasticity and neuroinflammation, and as a treatment for depression and other mental health disorders. Recent evidence suggests that early sensory and behavioral deficits in A…
View article: Olfactory bulb tracks breathing rhythms and place in freely behaving mice
Olfactory bulb tracks breathing rhythms and place in freely behaving mice Open
Vertebrates sniff to control the odor samples that enter their nose. These samples can not only help identify odorous objects, but also locations and events. However, there is no receptor for place or time. Therefore, to take full advantag…
View article: Cortex-wide spatiotemporal motifs of theta oscillations are coupled to freely moving behavior
Cortex-wide spatiotemporal motifs of theta oscillations are coupled to freely moving behavior Open
Multisensory information is combined across the cortex and assimilated into the continuous production of ongoing behavior. In the hippocampus, theta oscillations (4-12 Hz) radiate as large-scale traveling waves, and serve as a scaffold for…
View article: Modulation of metastable ensemble dynamics explains the inverted-U relationship between tone discriminability and arousal in auditory cortex
Modulation of metastable ensemble dynamics explains the inverted-U relationship between tone discriminability and arousal in auditory cortex Open
Past work has reported inverted-U relationships between arousal and auditory task performance, but the underlying neural network mechanisms remain unclear. To make progress, we recorded auditory cortex activity from behaving mice during pa…
View article: Modulation of metastable ensemble dynamics explains the inverted-U relationship between tone discriminability and arousal in auditory cortex
Modulation of metastable ensemble dynamics explains the inverted-U relationship between tone discriminability and arousal in auditory cortex Open
Past work has reported inverted-U relationships between arousal and auditory task performance, but the underlying neural network mechanisms remain unclear. To make progress, we recorded auditory cortex activity from behaving mice during pa…
View article: A genetically identified population of layer 4 neurons in auditory cortex that contributes to pre-pulse inhibition of the acoustic startle response
A genetically identified population of layer 4 neurons in auditory cortex that contributes to pre-pulse inhibition of the acoustic startle response Open
A fundamental task faced by the auditory system is the detection of events that are signaled by fluctuations in sound. Spiking in auditory cortical neurons is critical for sound detection, but the causal roles of specific cell types and ci…
View article: Amyloid Pathology in the Central Auditory Pathway of 5XFAD Mice Appears First in Auditory Cortex
Amyloid Pathology in the Central Auditory Pathway of 5XFAD Mice Appears First in Auditory Cortex Open
Background: Effective treatment of Alzheimer’s disease (AD) will hinge on early detection. This has led to the search for early biomarkers that use non-invasive testing. One possible early biomarker is auditory temporal processing deficits…
View article: Effects of Locomotion in Auditory Cortex Are Not Mediated by the VIP Network
Effects of Locomotion in Auditory Cortex Are Not Mediated by the VIP Network Open
Movement has a prominent impact on activity in sensory cortex, but has opposing effects on visual and auditory cortex. Both cortical areas feature a vasoactive intestinal peptide-expressing (VIP) disinhibitory circuit, which in visual cort…
View article: A Head-Mounted Multi-Camera System for Electrophysiology and Behavior in Freely-Moving Mice
A Head-Mounted Multi-Camera System for Electrophysiology and Behavior in Freely-Moving Mice Open
Advances in the ability to monitor freely-moving mice may prove valuable for the study of behavior and its neural correlates. Here we present a head-mounted multi-camera system comprised of inexpensive miniature analog camera modules, and …
View article: A Layer 3→5 Circuit in Auditory Cortex That Contributes to Pre-pulse Inhibition of the Acoustic Startle Response
A Layer 3→5 Circuit in Auditory Cortex That Contributes to Pre-pulse Inhibition of the Acoustic Startle Response Open
While connectivity within sensory cortical circuits has been studied extensively, how these connections contribute to perception and behavior is not well understood. Here we tested the role of a circuit between layers 3 and 5 of auditory c…
View article: A head-mounted multi-camera system for electrophysiology and behavior in freely-moving mice
A head-mounted multi-camera system for electrophysiology and behavior in freely-moving mice Open
Advances in the ability to monitor freely-moving mice may prove valuable for the study of behavior and its neural correlates. Here we describe a head-mounted multi-camera system for mice, comprised of inexpensive miniature analog camera mo…
View article: Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice
Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice Open
Speech evokes robust activity in auditory cortex, which contains information over a wide range of spatial and temporal scales. It remains unclear which components of these neural representations are causally involved in the perception and …
View article: A Cortico-Collicular Amplification Mechanism for Gap Detection
A Cortico-Collicular Amplification Mechanism for Gap Detection Open
Auditory cortex (AC) is necessary for the detection of brief gaps in ongoing sounds, but not for the detection of longer gaps or other stimuli such as tones or noise. It remains unclear why this is so, and what is special about brief gaps …
View article: AUTOPILOT: <i>Automating experiments with lots of Raspberry Pis</i>
AUTOPILOT: <i>Automating experiments with lots of Raspberry Pis</i> Open
Neuroscience needs behavior, and behavioral experiments require the coordination of large numbers of heterogeneous hardware components and data streams. Currently available tools strongly limit the complexity and reproducibility of experim…
View article: Auditory Cortex Contributes to Discrimination of Pure Tones
Auditory Cortex Contributes to Discrimination of Pure Tones Open
The auditory cortex is topographically organized for sound frequency and contains highly selective frequency-tuned neurons, yet the role of auditory cortex in the perception of sound frequency remains unclear. Lesion studies have shown tha…
View article: 5XFAD Mice Show Early Onset Gap Detection Deficits
5XFAD Mice Show Early Onset Gap Detection Deficits Open
Alzheimer's patients show auditory temporal processing deficits very early in disease progression, before the onset of major cognitive impairments. In addition to potentially contributing to speech perception and communication deficits in …
View article: Mice can learn phonetic categories
Mice can learn phonetic categories Open
Speech is perceived as a series of relatively invariant phonemes despite extreme variability in the acoustic signal. To be perceived as nearly-identical phonemes, speech sounds that vary continuously over a range of acoustic parameters mus…
View article: Gap encoding by parvalbumin-expressing interneurons in auditory cortex
Gap encoding by parvalbumin-expressing interneurons in auditory cortex Open
Synaptic inhibition shapes the temporal processing of sounds in auditory cortex, but the contribution of specific inhibitory cell types to temporal processing remains unclear. We recorded from parvalbumin-expressing (PV+) interneurons in a…
View article: Somatostatin-Expressing Inhibitory Interneurons in Cortical Circuits
Somatostatin-Expressing Inhibitory Interneurons in Cortical Circuits Open
Cortical inhibitory neurons exhibit remarkable diversity in their morphology, connectivity, and synaptic properties. Here, we review the function of somatostatin-expressing (SOM) inhibitory interneurons, focusing largely on sensory cortex.…