Frederik Barkhof
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View article: Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group
Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group Open
Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International …
View article: Blood-brain barrier water exchange in relation to amyloid, cognition and cerebrovascular burden
Blood-brain barrier water exchange in relation to amyloid, cognition and cerebrovascular burden Open
View article: Optimization of cervical cord atrophy measurement using a real-world, multicentre dataset in multiple sclerosis
Optimization of cervical cord atrophy measurement using a real-world, multicentre dataset in multiple sclerosis Open
Background Cervical cord atrophy is linked to disability in multiple sclerosis (MS). Cervical cord cross-sectional area (CSA) measurement for atrophy quantification using magnetic resonance imaging (MRI) has been technically validated, but…
View article: LLM enhanced graph inference for long-term disease progression modelling
LLM enhanced graph inference for long-term disease progression modelling Open
Understanding the interactions between biomarkers among brain regions during neurodegenerative disease is essential for unravelling the mechanisms underlying disease progression. For example, pathophysiological models of Alzheimer's Diseas…
View article: Polygenic pathways shape white matter vulnerability to Alzheimer’s disease-related pathophysiological changes
Polygenic pathways shape white matter vulnerability to Alzheimer’s disease-related pathophysiological changes Open
View article: Visual versus region-of-interest based diffusion evaluation and their diagnostic impact in adult-type diffuse gliomas
Visual versus region-of-interest based diffusion evaluation and their diagnostic impact in adult-type diffuse gliomas Open
ROI-based diffusion assessment guided by visual input showed superior reproducibility than visual assessment alone. Although visual assessment demonstrated strong correlation with ADC thresholds and comparable overall IDH prediction accura…
View article: Paramagnetic Rim Lesions in Pediatric Multiple Sclerosis and Their Association With Brain Tissue Atrophy
Paramagnetic Rim Lesions in Pediatric Multiple Sclerosis and Their Association With Brain Tissue Atrophy Open
PRLs are common in pediatric MS and are linked to greater lesion burden and gray matter atrophy. These findings suggest that PRLs are promising imaging biomarkers of more severe brain tissue damage although their ability to predict future …
View article: Automatic detection of simulated artifacts on T1w magnetic resonance images: comparing performance of different QC strategies
Automatic detection of simulated artifacts on T1w magnetic resonance images: comparing performance of different QC strategies Open
The reliability of MRI-derived measures critically depends on image quality. Poor-quality scans can obscure anatomical detail and compromise the accuracy of automated image analysis, underscoring the need for robust quality control (QC) pr…
View article: Characterizing individuals fulfilling clinical criteria for LATE in a tertiary memory clinic
Characterizing individuals fulfilling clinical criteria for LATE in a tertiary memory clinic Open
Limbic-predominant age-related TDP-43 encephalopathy (LATE) is characterized by an amnestic-and limbic-predominant phenotype, which can mimic the clinical presentation of Alzheimer’s disease (AD). Differentiating between LATE and AD is imp…
View article: Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning
Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning Open
INTRODUCTION The emergence, stability, and contributing factors of Alzheimer's disease (AD) gray matter subtypes remain unclear. METHODS We analyzed data from 1323 individuals without a diagnosis of dementia (CDR < 1) with T1w‐MRI and amyl…
View article: Effect of repurposed simvastatin on disability progression in secondary progressive multiple sclerosis (MS-STAT2): a phase 3, randomised, double-blind, placebo-controlled trial
Effect of repurposed simvastatin on disability progression in secondary progressive multiple sclerosis (MS-STAT2): a phase 3, randomised, double-blind, placebo-controlled trial Open
National Institute for Health and Care Research Health Technology Assessment Programme, UK Multiple Sclerosis Society, and the US National Multiple Sclerosis Society.
View article: Impact of a White Matter Reference Region on the Relationship between Florbetapir PET Measurements of Amyloid Plaque Deposition and Measurements of Cognitive Decline
Impact of a White Matter Reference Region on the Relationship between Florbetapir PET Measurements of Amyloid Plaque Deposition and Measurements of Cognitive Decline Open
The objective of this study was to systematically investigate both cross-sectional and longitudinal associations between amyloid PET tracer, Florbetapir (FBP), and cognition when different reference regions of interest – whole cerebellum v…
View article: Deep Learning Modeling to Differentiate Multiple Sclerosis From MOG Antibody–Associated Disease
Deep Learning Modeling to Differentiate Multiple Sclerosis From MOG Antibody–Associated Disease Open
This study provides Class III evidence that both a clinical/MRI algorithm and an MRI-based DL model accurately distinguish RRMS from MOGAD.
View article: Harmonizing genotype array data to understand genetic risk for brain amyloid burden in the AMYPAD PNHS Consortium
Harmonizing genotype array data to understand genetic risk for brain amyloid burden in the AMYPAD PNHS Consortium Open
INTRODUCTION We sought to harmonize genotype data from the predementia AMYPAD (Amyloid Imaging to Prevent Alzheimer's Disease) Consortium, compute polygenic risk scores (PRS), and determine their association with global amyloid deposition.…
View article: Single-centre, prospective cohort to predict optimal individualised treatment response in multiple sclerosis (POINT-MS): a cohort profile
Single-centre, prospective cohort to predict optimal individualised treatment response in multiple sclerosis (POINT-MS): a cohort profile Open
Purpose Multiple sclerosis (MS) is a chronic neurological condition that affects approximately 150 000 people in the UK and presents a significant healthcare burden, including the high costs of disease-modifying treatments (DMTs). DMTs hav…
View article: Periventricular gradient of normal-appearing white matter in normal aging and multiple neurological diseases
Periventricular gradient of normal-appearing white matter in normal aging and multiple neurological diseases Open
Clinically relevant periventricular gradients in tissue diffusion characteristics occur in normal aging and multiple neurological diseases, and share some underlying pathological mechanisms.
View article: Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging
Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging Open
Higher WMHVR was associated with HAR between approximately 70 and 73 years, independent of CVRF levels, APOE-ε4 status, and Aβ load, and not mediated by markers of neuroaxonal degradation. Although AD-specific pathology is typically…
View article: A Stage-Aware Mixture of Experts Framework for Neurodegenerative Disease Progression Modelling
A Stage-Aware Mixture of Experts Framework for Neurodegenerative Disease Progression Modelling Open
The long-term progression of neurodegenerative diseases is commonly conceptualized as a spatiotemporal diffusion process that consists of a graph diffusion process across the structural brain connectome and a localized reaction process wit…
View article: Effectiveness of Disease-Modifying Therapies in Patients With Late-Onset Relapsing-Remitting Multiple Sclerosis
Effectiveness of Disease-Modifying Therapies in Patients With Late-Onset Relapsing-Remitting Multiple Sclerosis Open
This study provides Class III evidence that patients with LO-RRMS have comparable outcomes with DMTs as patients with AO-RRMS over a 2-year period; this rating is because of baseline imbalances between treatment groups and a nonmasked outc…
View article: Two-step detection of Lewy body pathology via smell-function testing and CSF α-synuclein seed amplification
Two-step detection of Lewy body pathology via smell-function testing and CSF α-synuclein seed amplification Open
View article: Advancing multiple sclerosis management in older adults
Advancing multiple sclerosis management in older adults Open
View article: Reliability of serum neurofilament light and glial fibrillary acidic protein for detecting disease activity upon discontinuation of first-line disease-modifying therapy in stable multiple sclerosis (DOT-MS)
Reliability of serum neurofilament light and glial fibrillary acidic protein for detecting disease activity upon discontinuation of first-line disease-modifying therapy in stable multiple sclerosis (DOT-MS) Open
View article: CHIT1 and DDAH1 levels relate to amyloid-related imaging abnormalities risk profile in Alzheimer’s disease patients
CHIT1 and DDAH1 levels relate to amyloid-related imaging abnormalities risk profile in Alzheimer’s disease patients Open
The findings suggest that in the high risk group, there is a lack of upregulation in synapse and axonogenesis related proteins. High CSF CHIT1 and less increased CSF DDAH1 levels within AD relate to ARIA risk. From the literature, the link…
View article: A large-scale multi-centre study characterising atrophy heterogeneity in Alzheimer’s disease
A large-scale multi-centre study characterising atrophy heterogeneity in Alzheimer’s disease Open
View article: Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression
Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression Open
Higher serum ALA levels were associated with a lower risk of CDMS, relapses, and disability progression in a large prospective cohort. The results were null or inconsistent for other fatty acids.
View article: Real‐World Comparison of High‐Efficacy Versus Non‐High‐Efficacy Therapies in Multiple Sclerosis
Real‐World Comparison of High‐Efficacy Versus Non‐High‐Efficacy Therapies in Multiple Sclerosis Open
Objective The choice of the first disease modifying treatment (DMT) in multiple sclerosis (MS) is a topic of great interest, and whether high‐efficacy DMTs should be the first choice remains debated. We compared treatment outcomes (no evid…
View article: Revisiting Centiloids using AI
Revisiting Centiloids using AI Open
View article: Summary of Research: Blood Biomarker Dynamics in People with Relapsing Multiple Sclerosis Treated with Cladribine Tablets: Results of the 2-Year MAGNIFY-MS Study
Summary of Research: Blood Biomarker Dynamics in People with Relapsing Multiple Sclerosis Treated with Cladribine Tablets: Results of the 2-Year MAGNIFY-MS Study Open
View article: Understanding Mechanisms of Whole Brain and Regional Grey Matter Atrophy in Children With <scp>MOGAD</scp>
Understanding Mechanisms of Whole Brain and Regional Grey Matter Atrophy in Children With <span>MOGAD</span> Open
Objective To investigate the mechanisms driving whole brain and regional grey matter (GM) volume changes along with their clinical correlates in paediatric myelin oligodendrocyte glycoprotein antibody (MOG‐Ab)–associated disease (MOGAD). M…
View article: A novel approach to resilience and its links with education and Alzheimer's disease genetics
A novel approach to resilience and its links with education and Alzheimer's disease genetics Open
INTRODUCTION Cognitive resilience refers to maintaining cognitive function despite Alzheimer's disease (AD) pathophysiology. METHODS We analyzed amyloid‐positive individuals across clinical stages of AD in two cohorts: the Amsterdam Dement…